11. a. A GUNTZ took ij on 9th Dec.3j on 10th, 3iss on 11th and Zij on 12th and 13th, in infusion, without effect. After Ziij on 14th, at 4 p. m., slight headache and restless sleep. After same dose on 16th slight general headache till 9 p. m., restless sleep, and bran-like deposit in urine. Same dose on 17th gave same results, but Zij on 18th were without effect.
11 b. On Jan. 20th, 1823, G. took Zss and on 25th 3j, in powder, without effect. After 3iss on 27th, frequent eructations, afterwards nausea, malaise, fulness in stomach, and headache; n.was restless, and sediment was observed in m.; urine as before.
11 c. On m. of June 2nd, 1824, G.took an inf.of 3ss to Zx of water. After rumbling and some cutting in bowels 2 loose stools occurred. On 9th he took a Zj to Zx inf. After 1/2 hours slight scraping in throat for 5 m., and sense of fulness in head for 2 h. These effects also followed Zij on 10th and 13th. On these day there were also diarrhoeic evacuations about 2 p. m., pulse and appetite continuing normal; and urine became cloudy as before. (Ibid.)
12. a. HAASE took same doses as 10 a. without effect, save eructations and scraping in throat, till he came to the Zvj to Zxij infusion, on 16th and 17th Dec., 10 m. after which copious diuresis began and continued some h. On 18th and 19th same proportion of a Zj to Zxij infusion was taken, with similar but no further effect.
12 b. In Jan. Zss of powder was taken without effect, but Zj and Ziss doses were followed by eructations and diuresis as before. (Ibid.)
13. a. HEISTERBERGK began with the Zv to Zxij infusion, which had no effect; and the Zvj to Zxij, taken Dec. 16th, produced merely eructations; but latter dose next day caused after 6-8 m. general warmth over body, lasting 1/4 h. On 18th the Zj to Zxij was used, and general heat again ensued, passing off in 1/2 hours without sweating. On both occasions eructations also occurred. On a double dose of this infusion being taken on 19th, same effects followed, and urine passed in evening showed next m. a whitish sediment.
13 b. From Zss, Zj, and Ziss of powder taken 20th, 24th and 25th Jan., nothing was observed. From Zij on 28th nothing came save eructations, but on m. of 29th urine was cloudy and sedimentous. On 30th same dose had same effects, but also on rising 31st, a pressive feeling in left hypochondrium, which on coughing or deep breathing rises to acute pain; it lasted unchanged till Feb. 1st. (Ibid.)
14. KNESCHKE took all the infusions, but fruitlessly; and the same result followed his trial of the powder, in doses of Zss – Zij. In June, 1824, he took infusions of Zss and then of Zj in Zx of water. In 2 hours after second pulse fell from 75 to 70, and remained thus for 2 hours; during which time he had sense of fulness in head, with increased warmth of face. On 9th, at 8 a. m., he took a Zij to Ziiss inf. After 1/2 hours unwonted feeling of fulness in stomach, which lasted all forenoon, and at midday and p. m. spoiled his usually good appetite. From 10 to 12 there was congestion to head, with unaltered pulse. On 10th he took Zj of powder in Zj water. It was followed by eructations, fulness at stomach, and diminished appetite. On 11th, took Ziss at 9 a. m. Same symptoms as yesterday, and also a steady determination of blood to the head. The gastric symptoms lasted on into evening and even n. On 12th, 8 a. m., he took Zij in Ziss water. Eructations were not so frequent or so lasting as yesterday; in region of stomach from 9 till noon feeling of fulness and slight pressure, especially and cardiac end; very little appetite at midday. From 9 to 10 congestion to head, and for first 1/4 of this hour a not exactly unpleasant dulness of forehead. (Ibid.)
15. KUMMER took, Dec. 12th, 1/4 of the Ziij to Zxij infusion. After 3 hours slight pressive headache, spreading from forehead towards vertex, and especially towards eyes, causing pressive feeling in eyeballs on slight exertion of eyes. Next day took the Zss in Zxij inf. at 4 p. m. At 10 noticed confusion of head, changing repeatedly into pressing tearing pain, especially in frontal region. Slept more soundly than usual. Next m. felt as if pharynx were spasmodically contracted, which sensation lasted till 2 p. m. After 4 oz. of infusion Zv in Zxij, felt after 4 hours troublesome pressing pain in right frontal region, now and again extending to left side. Next day he took the Zvj in Zxij at 4 p. m.; towards 7 p. m. felt same pressing headache, which gradually spread from right frontal region over whole head, ceasing at times but soon returning, but without disturbing sleep at n. This headache passed off during subsequent sound sleep, but returned (less violently) at 2 p. m. next day, and lasted 3 h. After the Zj in Zxij, taken at 4 p. m. on 18th, noticed after 3 hours signs of congestion of head; pressing squeezing headache spreading from right frontal region over whole head, extending at times to eyes, leaving them sensitive to slight movement, and penetrating occasionally as far as angle of lower jaw on right side; therewith at times feeling like that of a limb “gone to sleep.” (Ibid.)
16. a. WINKLER took the first two infusions without effect. from the Zv to Zxij he had increased secretion of urine, in which on standing brown flocks formed. He then took the Zvj to Zxij. In 1/4 hours unwanted cheerfulness; urine as before. On 17th, experiment of previous day was repeated. Soon after dose a notable, almost petulant mirthfulness; pulse only a little quicker; urine dark red and turbid, with vermilion brick-dust cloud and sediment. On 18th the Zj to Zxij inf. was taken, with same result, – exhilaration lasting all day at intervals. No fresh symptoms resulted from repetition of experiment on 19th, save that pulse was somewhat quicker. Urine retained for several day condition assumed on 17th.
16 b. On Jan. 20th W – took Zss of powder without effect. On 22nd he took Zj; after which overnight urine showed brown flocks, and became turbid on agitation. On 23rd he took Zij. After 1/4 hours feeling of comfort an heightened cheerfulness. Urine as yesterday. On 25th Zij. No sensorial excitement; the somewhat scantier urine showed mucus in it. 27th. – Ziss in Ziss water. Felt very uncomfortable and low – spirited, with anorexia up to bedtime. Next m. very languid. Urine for days was brownish and turbid, with a vermillion deposit. It did not become quite normal till Feb 3rd. (Ibid.)
17. PIENITZ took inf. of Zss to Zx and of Zj to Ziss without effect. After Ziss, to 3iv he experienced all d.sense of pressure and weight in stomach and had, p. m., two pappy stools. (Ibid.)
18 a. SIEBENHAAR, at 9 a. m. on 2nd June, 1824, took inf. of Zss of Zx. Scraping feeling in throat for 1/4 hours; after 1/2 hours movement and rumbling in small intestine, lasting 1/4 hours movement and rumbling, with slight cutting in bowels, especially about navel, subsiding after 1/2 hours, and resulting in a normal evacuation. After Zss to Ziiss on 5th same symptoms, and after Zij to Ziiss nothing further than greater scraping in throat and slighter movement in bowels.
18 b. On 10th S. took Zj in Zj water at 8 a. m. About 9, violent eructations set in, and recurred frequently up to noon; about 10, rumbling and movement in bowels for about 1/2 h. He had not his usual appetite for dinner. On 11th took Ziss, with almost same effect, only this dose disturbed alimentary canal more and longer. On 12th, Zij in Zij water. Symptoms of digestive tube still more marked; fulness of stomach, so that little could be taken at meals, with frequent eructations and occasional disposition to vomit. After dinner, fulness of abdomen increased, still greater urging to vomit; indisposition to bodily or mental labour. Towards 4 p. m. disturbances subsided. (Ibid.)
19. ENDERS took, Jan. 23rd, 1830, Zss in Zj water without effect. On 24th he took, at 4 p. m., Zj, whereupon during evening occurred pressive headache in right forehead. On 26th, experiment was repeated, with same result; also considerable reddish deposit in urine. After Ziss on 28th headache was much more violent; urine as before. He was not well till 30th. (Ibid.)
20. STROFER took, Jan. 20th, 1823, Zss in Zj water. Frequent eructations; nausea even to vomiting; pressive headache, especially in forehead, all evening, and at n. slight sweat. 23rd. – Zj. Same eructations; greater nausea; pressive headache, but not specially in forehead, rather over whole crown. N. good. (Ibid.)
21. JORG himself experimented in 1822 and 1824; he gives the result of the latter proving only. On June 9th, at 8 a. m., he took a 3j to zx infusion. The peculiar taste of V. changed in 1/4 hours to one resembling the odour of violets. Whole body seemed somewhat excited; pulse for 1 hours was accelerated by 4 – 5 beats, but was not fuller or stronger. Natural appetite for dinner. From 3 p. m. much, sometimes foetid, flatulence; from 4 to 5 burning and cramp-like pains in gastric region; bread in evening had little taste. On 10th, at 10 a. m., took a Zij to Ziiss inf. Soon after, fulness in stomach without eructations, changing to canine hunger (prover had not breakfasted yet). In 1/4 hours after dose slight cutting in umbilical region for 2 m. In 6-8 m. after it feeling of fulness in head, especially under crown, lasting an hours, during which time pulse was quickened by 4 – 5 beats. At noon little appetite; after the canine hunger had subsided he not only felt stomach and abdomen as if replete, but there was a constant rising of a very peculiar scraping and nauseating irritation in oesophagus, without eructations, lasting till e. Also, p. m., distension, urine still more bilious; stools more frequent than usual, but each scanty and with some tenesmus. On 13th he took a Ziij to Ziv inf., with similar but heightened effects. After 1/4 hours moderate congestion to head, slight pressure under parietal bones, distension of abdomen. After 1 hours transient cutting in small intestines; diminished appetite, and return of the bilious rising of the previous d. P. m., frequent indications of pressive pain here and there on head. Urine was of a darker brown. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.