4. GROSS. – Sudden stunning in head, staggers and almost falls sideways, while standing; transient pain as from blow on vertex, painful stunning constrictive feeling, occupying whole head though starting from vertex as a centre, and disappearing first from other parts, finally from vertex blunt inwards pressure on right temple, intermittent (after 8 m.); fugitive twitches in right temple; tight drawing across forehead (after 5 m.); dull tension behind frontal tuberosity; dull pressive contraction in left forehead; painful drawing round orbits, more towards one side, especially on stooping (after 1/2 h.); slight twitching in right auditory meatus (after 1/4 h.); drawing in left mucus; fugitive repeated twitchings in left cheek-bone; painful twitching drawing, transient, in right cheekbone (after 1/4 h.); quick painless twitching from time to time below skin of left cheek, which he thinks must be visible, but which is not so- stroking with hand disperses it for a short time; repeated empty eructations; immediately after waking eructation of sulphuretted hydrogen; she has warm risings from stomach oppressing breath; sudden pressure in scrob. cordis, disappearing with rumbling; on cartilage of a left rib over scrob. cordis blunt-pointed intermittent pressure; a fugitive, sudden, quick cutting from scrob. cordis to region of navel (after 1/4 h.); bloated stomach; involuntary retraction of abdomen, with pain, pinching, and cutting; winding with some nausea in hypogastrium, as before menses; blunt pressing pain in abdominal muscles, as if bruised or from cold, worse during inspiration; bruised feeling on and about os pubis, increasing at times to a painful pressing or drawing; after regular motion strong urging in anus as if diarrhoea would follow, – this disappears gradually, but returns after some hours, so that he has again to go to stool, when he has only a natural motion; strong, hearty sneezing; fugitive twitchings like electric shocks below right axilla; during deep inspiration a dull stitch like outward pressure in left side of chest below axilla, lasting as long as the inspiration, – also pressure causes soreness; violent pain in left lumbar region above hip, as from over-lifting, worse standing or sitting than walking; in axilla, also in other places, on quite a small spot, pressure or blunt stitches as from a hard blunt instrument; pressure in head of humerus; repeated painful twitchings through humerus like electric shocks; sudden violent transitory twitchings in left hand, spot hurts even afterwards when touched; repeated electric twitching through left thumb; twitching in middle of left femur like electric shocks, then bruised pain there; from time to time dull pressure above left knee across thigh, then again descending downwards to knee; soreness in outer side of left knee; blunt pressure under left knee; great heaviness and lassitude of legs, standing, disappearing sitting (after 1/4 h.); bruised pain in front of middle of tibiae as if broken (for days); fugitive dislocated pain in right ankle – joint, worse standing, disappearing from walking; fugitive repeated twitchings in inner margin of right foot, like electric shocks (after 1/2 h.); sudden dislocative pain in right ankle, felt more standing than walking; painful slow drawing and twitchings in bones of limbs, sitting; drawing fugitive twitchings in many spots here and there; superficial twitchings in muscles; yawning and stretching of limbs; pulse tense, somewhat frequent and irregular, sometimes 2 – 3 beats are quicker; horripilations from nape of neck downwards; chilliness down whole body; warm all over except hip, where she feels as if cold water was poured on her. (Ibid.)
5. STAPF. – After 1/8 hours quickly passing nausea. After 1/4 hours stupid in head, with flying heat when bending forwards; violent pressure in forehead; followed after a few m. by stitches in forehead, especially over orbits, alternating with pressure,- stitches seem jerking out of eyes (lasting some h.); some stitches below left short ribs. After 1/2 hours feeling in head as after intoxication, some excitement; twisting when stooping as if everything was turning round; scratching in throat with ineffectual urging to hawk. After 2, 3 and 4 hours violent deep internal jerking stitches in middle of forehead, coming and going; painful drawing with stitches in middle of forehead, coming and going; painful drawing with stitches in muscles of left arm from axilla to fingers, a sort of tearing, unaffected by posture, much worse after second dose, disappearing after violent stitch in knee while walking, and replaced by pain up and down between left knee and toes (less walking than sitting), then slighter and entering right foot; violent stitch from axilla to fingers; heaviness in calves, impeding walking. (Ibid.)
6. WISLICENUS.-Rapid change of ideas, as during intoxication; dim confused recollection of former ideas and actions, changing with such rapidity as to render him quite stunned and blank as if dreaming (from fumes.). (Ibid.)
7. BARRALLIER proved the oil on several persons. a. 2 dr. in a spoonful to water were taken at 8 a. m., fasting, by a strong man of 40, pulse 64. 9, slight supra-orbital headache, especially on right side, gradually increased for an hours, after which it was replaced by slight heaviness of head, a slight pain still remaining over left eyebrow. Pulse 60. Even up to 2 p. m. there was a little weight in head, and at 3 urine became very copious, of high colour and strong odour; there was also pressure at epigastrium, and tasteless eructation; pulse 80. At 5 all symptoms had disappeared, save some fatigue and dulness of head.
7 b. A healthy man of 33, pulse 72, took same at same time. At 8:35, slight heaviness of head, as in commencing intoxication; foetid eructations; pulse has fallen to 68; diminished capacity for work; sense of heat at epigastrium. 9, lengthened yawnings; oppression of head continued; pulse 62. At dejeuner little appetite, everything tasting of V. (whose odour was also perceived in sweat and urine). In course of afternoon symptoms went off gradually, pulse rising to 76. (Bull. de Therapeutique, lix, 243.)
8. a. Healthy man of 21, pulse 80, took 6 dr. in water at 8.30 a.m., fasting. Immediate effect was nausea and salivation, but this soon passed off, and nothing more was noticed till noon, when he had repeated yawnings, and chill; at 1, irresistible drowsiness came on, and he slept profoundly till 3. Pulse, which had fallen to 62, now gradually rose, and at 4 was 96.
8 b.A healthy man of 19, pulse 64, took same at 8 a. m., fasting. Similar immediate effects followed. At 9, pulse was large, compressible, 56. Nothing more felt till 2, when skin became hot, pulse rose to 78, and face was reddened; agitation set in, then pronounced somnolence. Urine was copious, of deeper colour than in natural, and of strong valerianic odour.
8 c. Man of 19, in good health, pulse 80, took same at same time. Local effects lasted till 9:30, when pulse was 64. Slight headache and somnolence at 11; at noon profound sleep till 2; on waking, headache had gone, urine was as in last case; pulse at 5 p. m. 90. (Ibid.)
9. a. Healthy man of 20, pulse 68, took 10 dr. in water at 7 a. m. An hour after, nausea, pulse 56, sense of great dryness at back of mouth; frequent cough; slight headache. At 9, heat of skin; pulse small, contracted, 78; face reddened; nausea and risings of poton. At noon, general malaise; head dull and heavy; great tendency to sleep; dry cough at intervals; pulse 70; urine as previously. No appetite for breakfast or dinner.
9 b. Strong man of 48 took same at same time, pulse 72. From 8 to 9 pulse gradually fell to 60; weight at temples; heat of skin; urine as before. At 4 p. m. headache; pulse 74. All day strong distaste for tobacco, though he is a great smoker. At 6, much hunger. Sleepy in evening earlier than usual, and unbroken sleep during n., which he has not known for 3 mos.
9 c. Robust man of 41, pulse 70, took same. At 10, unusual perspiration, smelling slightly of V.; heavy headache; little capacity for mental work, inclination to sleep; pulse 64. At noon, irresistible sleep, which lasted 3 hours; general fatigue, especially in lower extremities; urine as before. Pulse, which was only 52 on waking, rose gradually towards evening to 72. (Ibid.)
10. a. ENGLER took at 4 p. m., December 12th, 1822, a fourth part of an infusion of Ziij of root to Zxij of water. Through evening he felt eager and more cheerful than usual. Same result followed next day a similar dose of a Ziv to Zxij inf. On 14th, same proportion of a Zv to Zxij inf. made head feel very free, and mental operations seemed carried on more easily and brightly. N. was quiet, but next m. urine was turbid, with a scanty whitish sediment. Last dose, on 16th, was taken from a Zvj to Zxij inf. N. was restless, and urine in m. turbid, with a mucous deposit, which dissolved on slightly agitating vessel.
10 b. On Jan. 23rd, 1823, E.took at 4 p.m. 3ss of powdered root in water. Sleep at n. was disturbed by dreams, and urine next m. was cloudly, with a whitish mucous deposit. On 24th he took 3j. During e. he was unusually gay; n. was very restless, with vivid dreams towards m.; urine was as before. Same results followed 3iss on 25th and 3ij on 31st. (JORG, Materoalien.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.