2. Same gave to 2 young buck rabbits 5 dr. of 1x dil. on 9th, 10th, 11th, and 12th Oct. In first, latest dose (given 11:15 a. m.) caused retching. After pressing lumbar vertebrae laterally between finger and thumb, rabbit turned on left side as if moribund, and passed a stool. L. eyelids inflamed and agglutinated. Hepatic region seemed tender, but there was no soreness on pinching kidneys sharply. It died in middle of day P. M. 14th, 10 a. m. – Stomach contained food, and was thickly coated with viscid white mucus. An ulcer as large as a hemp seed, surrounded by a red areola, on great curvature 1/2 in. from pylorus. R. Kidney very pale, 1. dark. Second rabbit died during n. of 12th. P. M. at same time as first. Stomach was same as first in every particular, but ulcer was 1 in. from pylorus. Spleen was very small and pale in both, and medullary layer of kidneys of much deeper colour than cortical. All else healthy. (Ibid.)
3. Oct. 17th, 11:30 a. m., 10 dr. of sat. sol. were injected into cellular tissue of a rabbit’s right thigh. 18th. – Has taken no food; lies on left side, making ineffectual efforts to rise. Died in n. 19th. – P.M., 10:30 a. m. Bladder filled with pale urine of alkaline reaction, with copious flocculent deposit, but containing no sugar; funds extends nearly to umbilicus. Stomach full of food; same excess of mucus as in No. 2; pylorus congested; about 1 in. from pyloric end, and at anterior surface, a yellow patch measuring 1/2 in., surround ed by a pink congested areola. Liver: lobules very distinctly seen on surface, on which appear a few pale vermiform markings, with prove to be tubes traversing substance of gland. All other organs perfectly healthy. (Ibid.)
4. a. October 22nd, 10:30 a. m., injected 1 dr. of 1x dil. under skin of thigh of a full-grown tom-cat. 24th. – Dose repeated. 25th. – Copious salivation. L. eye, which was slightly inflammed before experiment, now weeps much; lids are closed, when forced open purulent acrid matter flows from them; marked photophobia. 26th. – Less salivation; eye better. 27th. – Salivation slight; eye well. 30th. – 5 dr. were injected. Nov. 1st. – 1 dr. of sat. sol. injected. Copious flow of clear, extremely viscid, alkaline saliva. 2nd. – Rectal temp.
101.2x; slight salivation. On 4th 5 dr., and on 8th 20 dr. were injected. On latter day urine is reported “natural in quantity, acid, pale, turbid, contains sugar, LECONTE affirms that within the first 3 or 4 d.that follow the ingestion of Uran. mur., sugar is found in abundance in the urine when it is possible to procure it, for secretion of urine and action of bowels are suspended on 2nd and 3rd d.(Arch.gen.de Medorrhinum, 1854, p.728.–Leconte’s observations are contained in a thesis presented to the Paris Faculty of Medicine in 1853, which we have not been able to obtain. Dr.Curie states that he has verified Leconte’s results.–EDs. with copious albumen and chlorides; ” does not salver, except under influence of terror; is now much emaciated. 10th.- Coat is rough; purulent discharge from left nostril; no appetite; ineffectual tenesmus; cough; trembles and totters when attempting to walk. Died that n., lying prone.
4 b. P. M., 11th, 9:30 a. m. – Stomach and duodenum full of dark blood. Former contains no food; surface covered with pin’s-head ecchymosis. In latter are two large ulcers, with well- defined margins, surrounded by congestive areolae, and with black coagula adhering; one had nearly perforated. Rectum full of very hard dung, and bladder of faintly acid urine, which is albuminous, but contains no sugar. Lungs can be inflated, save in lower lobes, and these float in water; grey miliary spots are scattered over surface, and on cutting through lower lobes similar spots are seen, which, when placed under microscope, look like grey tubercles. (Ibid.)
5. Two young rabbits were taken from same litter, and into thigh of one a dr. of sat. sol. was injected. It died 3 day after, when its fellow was killed, and both examined together. Organs of latter were found perfectly healthy; but in former, on great cul-de-sac of stomach, an ulcer was found size of a pea, surrounded by a florid raised border. There were zij of pale yellow fluid in abdominal cavity, which coagulated on boiling. (Ibid.)
6. Besides the preceding seven experiments, the drug was administered, under the skin usually, to 12 animals-3 rabbits, 7 cats, 2 dogs. With the exception of the eye-symptoms, the results wee in the main coincident with preceding observations.
RABBITS.- Of the 3 rabbits, which died in 3, 4 and 5 day respectively, 2 had congestion near pylorus. 1 had albuminuria (normal in the rabbit), 1 had ascites, hydropericardium and pleuritic effusion.
CATS.- Of the 7 cats experimented on, 1st had vomiting, thirst, duodenitis, ascites, albuminuria. 2nd, vomiting, thirst, emaciation and hydropericardium. 3rd, vomiting, pyloric congestion, peritonitis and ascites, perinephritis. 4th, pyloric congestion, peritonitis and ascites, perinephritis. 4th, pyloric congestion and ulceration. 5th, purulent peritonitis. 6th, highly albuminous urine. 7th, slight albuminuria. All had marked anorexia. The vomiting in the cats is valuable because in each case the drug was introduced into cellular tissue of hind leg.
DOGS. – 1. Hydropericardium and pneumonia. 2. Anorexia; no organic change.
Five of this group of 12 animals had vascular changes noted in the neighbourhood of the pylorus. Ulceration was found in one. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.