4 b. Same took 5 dr. 3 times a day for d. Ist day-Thirst, drinking much at a time; feverish. 2nd. – For short time, very acute shooting inwards in scrob. cordis. 3rd day – Bowels have not acted for 2 d. Feeling in right eye as if water ran about in it. 4th day – Black spots before eyes, moving with eyes, in evening after dark, by gaslight.
4 c. Same took 5 dr. at 7 p. m. for 5 days 2nd day-Spots before eyes as before, by daylight only. Shooting inwards in stomach, first on left side, then on right 4th day – Bright spot before eyes, only when looking at gas – flame. Took same on 9th, 11th, and 12th day 10th day-Slight stationary pain in stomach- pit. 11th day – Watery diarrhoea, preceded by violent crampy pains in bowels. This lasted 3 day 14th day – E. after sunset, soon after a meal, vomited food mixed with nearly black, thick, and clotted blood; vomiting was difficult, causing shooting pain at stomach – pit, and was preceded and followed by retching. (He never vomited blood before.) (Ibid.)
5. SCHNELLER began with 5 dr. of the tinct., this was irregularly increased up to 120 dr.; after an interval he took again 50 dr., and as a last dose 200 dr., – altogether about 3/4 oz. Up to 30 dr. for dose he had only flying stitches in gullet, pappy taste, and rumbling in abdomen. At 40 dr., after 4 hours confusion of head and dryness of mouth. During doses up to 100 dr. these symptoms increased; vision became somewhat weak; nasal secretion diminished during forenoon, increased in e; oppression of stomach and diminished appetite. These symptoms went off after omitting medicine for several d. After 120 dr. they returned, with some variations. In 2 hours there was nasty bitter taste, with yellow furred tongue; after 3 hours spitting of white frothy fluid, dryness of mouth and nasal mucous membrane, and confusion of head; later flowing of liquid, fetid, yellow mucus from nose, with relief, hoarseness, difficult speech, drawing pain in fauces, oppression of stomach, inodorous eructations, want of appetite, disgust at food, some thirst for certain fluids. In evening most of these symptoms went off. After leaving off for 4 days, on again taking 50 dr. exactly the same symptoms were experienced as when he took such dose before. He then took 200 dr. Same symptoms were repeated; and in addition frequent yawning, with desire for sleep, which was, however, restless; also increased irritability of temper. (Wien. Zeitschr. d. k. k. Ges., Jahrg, ii, Bd. 2.)
6. A student took 5 – -6 gr. of extract. “Two hours after having taken dose my throat began to feel intensely dry, which increased to that extent that I could not swallow, and with great difficulty breathe; my tongue felt quite spongy and totally devoid of moisture. The narcotic effect soon became evident, and I reeled as though intoxicated; pupils were very dilated, and I was at one time nearly blind. I felt nervous, excited, and irritable, and continually paced up and down my room. The next d. I could scarcely see, and was quite unable to read a book when I tried. For 3 weeks afterwards I had a very sensible pulsation over my right eye, and even now – after 5 weeks have elapsed – seem to feel the effects of the poison in my eyes, sight being at times quite dim. I was always relieved for a few seconds by imbibing any liquid. The serious effects lasted about 8 h.” (Taylor, Guy’s Hosp. Reports, 1865, pp. 293 – 5.)
7. Dr. J. R. COXE, jun., aet. 57, took, Sept. 20th, 1857, 3 doses of 10 dr. of 1x dil., and the same on the 3 following days 20th. – No symptoms save pain in right temple, sticking and stabbing, at 8 p. m., felt till he fell asleep at 11. 21st. – Out of temper, irritated all day; headache in both temples, shooting to back of head, with considerable thirst, drank much more water than usual; inflamed, and weep much, particularly r. face slightly swelled and eyes puffed (i. e. skin below them); head all day wet with perspiration. 22nd. – Violent headache; great confusion of ideas; very irritable; right eye weeps very much, left eye a little; hears better to – day than for a long time; dryness of mouth; drinks a good deal. A kind of burning pain in stomach comes and goes, lasting for 1/2 hour, then intermitting for an hour or more; mouth full of saliva unable to pass urine freely, had to strain; dryness in throat; pains in lumbar region like rheumatism, back very stiff but not very painful; pulse usually 72, was at 9 p. m. 84; skin hot. All above symptoms continued, in diminished degree, up to m. of 26th. In addition, on 23rd and 24th, hands and feet up to knees were affected with slight spasms or jerks, especially fingers of left hand, which jerked repeatedly and without pain; numbness and stiffness of left leg, with tickling creeping feeling under cutis, which passed off by rubbing and stretching. (Amer. Hom. Rev., iv, 559.)
8. CHAS. CHAUNCEY COXE, aet. 11, took twice on Sept. 21st, and thrice on 22nd and 23rd, 12 dr. of 3x dil. 22nd. – Great pain in head; stiffness of neck and sore throat; head perspired more than usual. 23rd – 29th. – Headache and stiff neck, gradually wearing off; pain in right leg, worse at patella; much saliva in mouth; throat feels sore the whole time. On Oct. Ist had only slight pain in right temple, and sore throat, which disappeared on 3rd. (Ibid.)
9. An old man, suffering from pains in right shoulder and leg, and permanent contraction of right arm, but otherwise well, took powdered leaves of dat. tatula. On Ist day took 12 gr. in 2 doses. 2nd day – Took 3j. Colic pains, frequent stools; dryness of mouth and fauces, fear of inability to swallow; pain in temples; opening between eyelids contracted, pupils dilated; vision disturbed, cloudy; no sleep; agitation; pain in head and right arm. 3rd day – Same dose. Colic; slight headache in temples; bad n., with agitation. 4th day – Took 3ss. Troubled and extremely weak vision in morning; at noon left eye natural, but right eye blind; all right side more affected. 5th day – Same dose. Colic with stools; difficult micturition, face rather pale; right eye still affected. 6th day – Same dose. Sleep disturbed; great headache during night; weight of head p. m.; urine scanty and voided with difficulty; dryness of mouth continues; singular expression of countenance; eyes seem smaller. 7th day – No medicine. Vision of right eye still disturbed. 8th. – Effects of drug passed off. Had taken 158 gr. in 8d. (BARBIER, Mat. Medorrhinum 1824, iii, 415.)
10. A man with right prosopalgia took 9 gr. of powder in 3 doses. E., great dryness of mouth and throat; pupils dilated; apparent dryness of surface of eye; no stool. 2nd day – Took 12 gr. in same manner. Dryness of mouth; constant thirst; slight colic pains; eyes drier and irritated; agitated n., no sleep; pulse generally quick. 3rd day – 18 gr. Great dryness of mouth; thirst; colic; 3 stools; micturition slow; rushes of heat to head, causing threatening of syncope; pain in left head; no cephalic congestion. 4th day – 24 gr. Symptoms continue. 5th day – 24 gr. Cannot distinguish objects; conjunctiva red and irritated; singular expression; pain in limbs; cannot keep himself up; no weight of head; calm sleep part of n. 6th day – 30 gr. Great weakness of limbs; no depression; sleep agitated; eyes irritated; painful pricking over whole body during n. 7th day – 36 gr. Effects increased. 8th d.45 gr. 9th day – 45 gr. Some oppression of head, which is heavy, especially when the rushes of heat to it take place; muscular strength annihilated; difficult micturition; sleep disturbed by dreams; transient blindness. 10th day – Medicine discontinued. 12th day – Debility of limbs continued with dryness of mouth and throat. 13 day – Only weakness of limbs, which lasted some day longer. Took 243 gr. in 9 day (Ibid.)
11. a. LEONARD PRATT, student, took 5 dr. of tinct. at 7 a. m. After 3 hours, feeling of enlargement and protrusion of eyeballs; jerking of muscles of arms, followed immediately by darting pains through forehead. After 5 hours, dartings through head in different directions, extending to balls of eyes and down right side of nose; tearing pain in right ear, with shooting through forehead and vertex. After 6 hours, sharp twinging pains near external condyle of humerus; jerking twinging pains in muscles and tendons of back side of left forearm, extending to index; constant throbbing in head, deep – seated; dim sight, as though atmosphere was foggy. After 9 hours, sense of fullness in head; beating in vertex and forehead, felt also in eyeballs; throbbing pain in left lower molars, and in submaxillary gland of same side; pulse fuller and 10 beats quicker than usual. After 13 hours fullness of vessels conjunctiva and sclerotic, eyes looking red, particularly near external canthus; soreness in eyeballs on turning them. After 14 hours, frequent sneezing. On 2nd day, at 7 a. m., heavy beating in arteries, particularly felt in head and chest; throbbing in teeth of left lower jaw and in eyeballs, worse in left, with lachrymation; pulse 15 beats faster than usual, and very full and heavy. Did not rest well at n., frequent waking; wandering indistinct dreams; obliged to get up 4 times to urinate. Without note of time – bearing in forehead and balls of eyes.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.