3. 3j of datura tatula (in what form is not stated) with 3x of water was given to a horse, pulse 36, temp. 99.6, resp. 8. Within an hour, restlessness, urinated and passed feces once; dry cough at intervals. Temp. at end of hours 100.2. After 4 1/2 hours, temp. 100.4, pulse 38. Gave 3j in 3vj of water, and in 35m. pulse was 40. Next day gave same horse 3iss wi 3vj of water, temp. 100.2, pulse 36, resp. 8. In 1 hour pulse 54, temp. 100.4; mucous membrane of eyes, nose and mouth injected. In 6 hours all effects passed off. Next day gave 3iij with 3iv of water, pulse 36, temp. 100.3. In 1/2 hour greenish discharge from nostrils, cough at intervals, tongue and buccal membrane dry, pupils dilated. In 1 hour temp. 100, pulse 34; nasal membrane dry; twitching of facial muscles and gaping; pupils less dilated and tongue moist. Three days after, same horse had 3iv with 3iv of water. Effects produced were dilation of pupil; dry mucous membranes; coughing; twitching of facial muscles; sighing, with shallow respiration; temp. rose from 99.8 to 100.6; pulse was small, soft, and compressible, and rose 4 beats. (BURNESS AND MAVOR, Specific Action of Drugs, p. 151.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.