12b. 19th. – Ten gr. of 3rd trit. at 6:30 a. m. 6:45, slight nausea; transient darting pains in frontal and temporal regions. 7, griping in right hypochondrium; fronto – temporal pain, worse from motion; deep sighing. 7:30, head – pains still, with heavy feeling; pulse variable; giddiness; nausea; resp. still sighing. 9, griping pains in stomach, and great oppression; nausea and giddiness worse from motion, better in open air; darting pains in right hypochondrium; constriction of head, as if a tight bandage were round it. 11, soreness and transient pains in epigastrium; soreness and pains as from rheumatism in left side of neck; pulse variable; giddiness; stomach unsettled; sighing; feeling of soreness in lumbar region. 2 p. m., transient pains in stomach, with sense as of undigested food there; acute pain in left elbow, and darts of pain from thence to 4th and 5th finger of same side (these pains seemed to begin in left neck and extend to left leg; they were constant for hours); epigastric region sore to pressure; giddiness with constricted feeling of head. 3, still pains in head, stomach, and arm. 8, giddiness has been constant. 9, some trouble in stomach continues; soreness in lumbar region, with dull, heavy pains; a kind of paralysed feeling in left side throughout. 20th. – Quiet n., but on waking 2 or 3 times felt darting pains in stomach and paralysed feeling in left side. Urine now pale and copious; stool lumpy, mixed with watery discharge; still soreness and pains in stomach. 10 p. m., during day giddiness and nausea; dull pain in head; heavy pains and soreness in lumbar region; urine as in m. (Ibid.)
13. Dr R. C.SMEDLEY took 5 gr. of 30th trit. Once on Oct. 29th, 1873, and 3 times on 31st. No symptoms on these day, but on Nov. 1st bowels, which had been somewhat costive, moved twice, and appetite was diminished. Took same dose at 6 and 10 a. m. and 4 p. m. In forenoon sense of fulness and dull pain in transverse and descending colon; two soft stool after dinner, with same pain, and tenesmus, also again in evening 2nd. – Five gr. at 6 and 11:30 a. m. and 4:30 p. m. Not much appetite; two soft stools after breakfast, with same pain; drowsy in forenoon, head heavy and dull. Same evacuations and pains after dinner; brain felt tired. Lay down and slept (which he is not wont to do.); dreamt that head was full, brain revolving upwards from front to back, and that he was almost blind; after waking, brain felt confused, numb or tired feeling in limbs, pulse accelerated. Same stool and pain, with tenesmus (extending to bladder, as it did on previous e.), and at 10 p. m. slight epistaxis. 3rd. – Headache in m., with epistaxis, and same kind of stool after breakfast, with tenesmus of rectum and bladder during and after it. At 6 a. m., 3 and 8 p. m., 10 gr. each time. No symptoms except epistaxis while at supper; looseness ceased On 4th took two doses of 10 gr., and on 5th and 6th two of 20 gr. each, without effect. Same absence of result followed repeated doses of 10 gr. of 3rd from 8th to 15th, save that he was constipated during days on which he took none, and feels but not loosely moved when he recommenced it. (Ibid.)
14. Dr. HOUGHTON took dose of 3rd trit. at 8 p. m. In 1.1/2 hours uncomfortable sensation in right ear, felt inclined to bore in with finger; then eructation, twice, each time causing sudden pain running from throat along Eustachian tube to middle ear, leaving in latter a transient stabbing. The desire to bore occurred repeatedly on several successive evenings. Next day felt pains in right arm, as from hitting the nerve, tingling, extending from elbow down ulnar surface and into 3rd finger; repeatedly for 3 day (Ibid.)
15. Miss S – took same. Headache across top of forehead, increasing till she went to sleep at night; pain in right wrist (deep in bone) as if squeezed and gradually let go, also deep under right shoulder – blade, transient, while sitting, and in right great toe. (Ibid.)
16. Dr. HERING gave a man, March 13th (1865), I gr. of 3rd trit. at 5:30 p. m. Nothing following, he took 2 gr. at 8:20; in 5 m. dull pain in left occiput, lasting 10 m. On 25th took several dr. of tinct. In 1/2 hours heaviness in stomach; later, a stimulus, as he called it, in neck and occiput, going through whole head till it reached eyes, lasting an afternoon and e. Next day, sleepy, headachy, acted foolishly and said he felt crazy, and also as if he had taken a cold. [ There is also noted on this day “His eyes were worn as usual, the sight bad all the time. Rather dull; clouds passing over the sun interrupt his walking” It is not clear from this enigmatical statement whether the drug had anything to do with the phenomena in question. EDS.] Next day sick at stomach; prostrated; felt severely indisposed; had to lie down, and wanted doors to be shut; pains in eyeballs. (Ibid.)
17. Dr. BERRIDGE induced a gentleman to prove Ph. He took 5 gr. of powdered bean on retiring; slept well; woke with considerable stiff pain in hepatic region posteriorly, tender on pressure and on first moving; it went off after moving about a little. Disinclined for breakfast, slight nausea; looked tired. 10:30 a. m., took 6 gr. Noon, great languor; very distinct nausea in throat, and feeling as if he would be sick. Tensive headache, brain and scalp felt tight; mental work difficult; hands feel tremulous, as if he must make an effort to keep them steady; in walking, feeling of unsteadiness from knees downwards, so that he had to tread carefully, felt especially when eyes were shut, he must look to where he is going; can see farther than usual (he is naturally myopic), pupils contracted. On going out had to take a stick to steady himself, and had feeling of weakness in ankles. Determined exertion of will conquers the unsteadiness. In m. before 2nd dose, and lasting all day, noisy emission of flatus P. m., whilst walking, stiffness in both recti femoris. Enjoyed dinner at 1, but could not eat much on account of the nausea; this was relieved by lying, and he could eat a little more; after again resting, all symptoms passed off. Next m., same pain in hepatic region, and also stupid feeling in head. (Ibid.)
18. [ The provings 18-38 were made by students, under the superintendence of, for 18-28, Dr. T.F.Allen, for 29-32, Dr. Hoyne for 33-36, Dr. C.W esselhoeft, and for 37-39 Dr. A.K. Hills ] a. R. W. STONE began, at 3 p. m. of April 3rd, 1873, to take 1 gr. of 1x trit. hourly. 4th. – 9 a. m., throat had become very sore, with feeling as of a fish bone lodged in it; swallowing of saliva very painful. At 8:30 p. m., violent and very unusual hiccough for 45 m., with great distress for breath. It was relieved at once by sleep, but on waking at 2 a. m. it recurred for 1/2 h.
18b. On 6th, at 2 p. m., began to take 4 dr. of saturated solution every 1/2 hours 7, again painful constriction of throat, soreness felt all through back of pharynx, with painful swallowing of saliva; by 10 throat had become quite dry. 7th. – 11:30 a. m., benumbed sensation of hands, very much increased by feeling pulse, which on right side was double the strength of that of left 4 p. m., pain and constriction of throat continued, and small ulcers with yellow centres were seen on right side of pharynx behind tonsil; posterior nares also were dark red. 10th. – Throat very sore, very difficult to swallow, and examination shows pharynx studded with small ulcers, especially on right side, where pain is greatest. Excessively nervous; cannot endure the pain. 12th, – Though medicine has been discontinued for 2 or 3 day, throat symptoms continue, but less violent; examination shows uvula considerably elongated. Sharp headache on right side, transient.
18c. On 14th, at 8 a. m., began taking every 1/2 h. I gr. of 2x trit. 10 a. m., heavy, dull, and oppressive frontal headache, with peculiar inability to express thoughts clearly and intelligently. 17th. – 2 p. m., sudden and severe headache over right eye, with pulsation felt in occiput. 3:45, severe muscular pains beneath clavicles, extending down inner sides of both arms. 18th. – At 2 p. m., took 5 gr. followed in 5 m. by constriction of throat and dysphagia. During whole p. m. throat was very sore, examination showing enlarged tonsils and elongated uvula; swallowing or speaking was very painful, and posterior part of tongue was tender to touch.
18d. 23rd. – No more medicine having been taken, this m. took 30 dr. of saturated solution, followed in 10 m. by severe pain in both mastoid processes. 24th. – At 8 a. m. repeated dose. 10 p. m., nausea on lying down, though none had been felt before; throat constricted as previously, but higher up. 25th. – 7 a. m., throat very much constricted, and great difficulty in eating, passing away before breakfast was finished. Examination shows posterior superior portion of mouth much injected. At 8:30, took 30 dr. more, followed by an all – gone feeling along oesophagus, and headache, with, at 3 p. m., sense of great debility. (Ibid.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.