9h. Sore feeling extending from small of back around both sides over the ossa ilii, worse on pressure. Pain in lower abdomen, attended with diarrhoea and also flatulence, after taking first dose.
9i. Sensation as if there was a raw spot in the centre of the urethra, which woke him up 2 n. in succession.
9j. Rush of blood to back part of head, attended with violent itching and heat extending to each ear; and behind left ear there came three hard lumps, one the size of a small shot, the other that of a buckshot, and the last a size larger. On the same n. sharp pain in region of the kidneys, as if one had driven a nail on each side of the vertebrae. Copious discharge of clear urine. Flow of mucus from the right nostril, lasting for 3 d. Pain on the 7th rib of each side in a sport as large as a quarter of a dollar, more on l. Great constipation, lasting all the time he took the medicine, and for a long time afterwards. Bleeding piles for 2 d. Violent itching in anus, worse at n. in bed. A whitish furred tongue in m.
9k. Violent itching of corona glandis with a profuse secretion of pus; the itching was so violent as to cause him to rub it, which only eased it for a short time, to return with tenfold violence. Two small red spots made their appearance on each side of glans, secreting a large quantity of lardaceous matter. It had the appearance, according to his opinion, of herpes preputialis. Profuse sweating between thighs. Violent erections in e. After finishing the medicine all desire for an embrace is lost, which was not the case before he took it. All the above symptoms, except the perspiration, were most violent at n. in bed; the sweating about 12 noon. He had also a constant pain in left arm – joint when turning and straightening the arm, and when writing. (Ibid).
10a. Dr. ALBERT LINDSAY, dark hair, aet. 28, took, Jan 11th, 1851, 20 pellets of 6th on going to bed. He uses no coffee, tea, spices, nor any stimulants. Great restlessness at n., continual dreaming and waking. He would be scarcely lost in a drowse, before he would be dreaming vivid dreams of studies and business, &c. Drawing – aching pains in thighs from hip – joints nearly down to condyles, aggravated by moving, and accompanied with great lameness, experienced on getting up and attempting to walk, getting better after walking a short distance. This continued next day 13th – Took 20 globules at bedtime. Had many dreams and woke up often. 14th – Took 20 globules at 7 a. m. Shooting – aching pain on posterior side of right thigh from hip – joint to middle of os femoris, about 9 a. m., on straining at stool. In evening of same day took again 30 globules. Continual restlessness, and dreams that a lump was in his throat and right ear. 16th. – At n. 20 t 30 globules. In addition to restlessness and dreaming, woke up with throbbing pain in organ of conscientiousness, extending to forehead over eye. During day and n. of 17th he was troubled with aching pains in thighs, and soreness in umbilical region. Weak sensation in left eye during 28th. Vivid dreams of the lectures, particularly the anatomical, during n. of 18th; he could not believe that he was not actually there. Almost every m. after waking a kind of dull pain (some m. sharper and more intense) in forehead and top of head, worse when lying on left side and back, going off when turning to right side and pressing forehead into pillow. As soon as he turns to left side or the back the pains return. On turning to right side, or getting up and washing, the pains disappear. Violent itching and picking on inner side of knee – joint ever since he has commenced to take the medicine, worse at n. and in m. before getting up. 21st – Violent itching on inside of thighs, knees, and legs, worse at knees, especially at n.
10b. 22nd – At bedtime took 5 gr. of 3rd trit. Had several dreams, and awoke several times through n. On waking up in m. had aching pain in the whole of forehead and top of head, aggravated by lying on left side and back, relieved by lying on right side and pressing forehead with pillow. A dull, heavy, and at times sleepy feeling during day 24th – Restless sleep with many dreams, feels very tired in m., aching across small of back and in limbs. A kind of throbbing pain in forehead on waking, going off on pressing head on pillow. 25th and 26th – Same pain in diminished degree. 27th – Symptoms of cold in head, – fulness of head, discharge of much mucus from nostrils, aching pain in the small of the back and legs. Uncommon tiredness and weakness. Sensation of emptiness in stomach, is very hungry within 2 hours after eating a hearty breakfast. Sore on inside of the under lip towards left 28th. – Severe aching and drawing pains in back from region of kidneys to sacrum, and in thighs and legs, all last n. and today. Drawing up of legs affords relief. He did not wake up with headache in m., but about 9 a. m. a kind of sore pain commenced at crown of head and extended as far front as the organ of veneration (at times there is a slight sensation of throbbing); it is very sensitive to touch, he cannot even touch the hair without causing a sore pain. This pain continued all d. Weakness and sleepiness in eyes about noon, could scarcely keep them open. 29th – No pain this m., but scalp is sensitive to touch. Slight pains in back and legs, but much better than yesterday. (The prover here remarks that when he was from 13 to 17 years of age he took large quantities of calomel, and was in consequence for years afflicted with terrible drawing, aching pains in the legs, especially 12 – 20 hours before a storm. He was a regular barometer. The pains he experienced were exactly like those he suffered years ago from calomel. He was, of course, entirely ignorant, like all the others, of the nature of the medicine he had taken to prove.) (Ibid.)
11. Dr. C. L.MERRIMAN, aet 31, light hair, nervous – sanguine temperament. Took 28th Jan.,20 pellets of 6th dil. at 10 a. m. In 2 hours felt fulness and general pressure in whole head as after taking cold, with dull aching pain in the region of benevolence; better in the open air. Great drowsiness and lassitude in warm room; occasional shooting and prickling pain in two middle fingers of left hand, better by firm pressure upon thumb. The above symptoms continued about 8 hours 30th. – 20 pellets of 6th. Symptoms similar in kind, but somewhat less in degree, and passing entirely away in about 8 hours (Ibid).
12. Dr. S. L.MULFORD, of good constitution, not predisposed to any acute or chronic disease, Jan. 25th. 1851, took 5 gr. of 3x trit, on going to bed, but without producing the slightest effect. Feb. 2nd. – Repeated dose without any effect. 3rd – Took 10 gr. of 1x trit. Shooting pains in forehead with great heaviness. Shooting pains in inner canthus of right eye with burning and itching. Hoarseness of voice in m., going off in 2 or 3 h. Shooting pains in bowels at intervals during d. Flushes of heat, confined to abdomen, with great flatulence. All the above symptoms more in forenoon and less in afternoon and evening 4th. – Pain in bowels before each evacuation; all the other symptoms as detailed above in a less degree. (Ibid).
13. Dr. T. M. RANDELL, aet. 20, dark hair, took, Jan 13, 1851, 20 globules of 6th dil. Seemed to lower pulse in forenoon and make it irregular. 11:40 a. m., pain in left side of head, temple, and supra – orbital ridge; sensation as if abdomen was too large, and wishes to have everything loose about bowels. Numb pressing pain in eyes. Numb feeling in elbows, as if ulnar nerve was compressed; also numbness in knee – joints. Hands cold. Pain in forehead. Sticking in chest just beneath sternum. Griping pain in bowels. Pulse, which was at 12 (noon) from 44 to 52, rose at 4 p. m. to 80. Pain in organ of tune. Sensation as if there was something in ear. In afternoon his friends remarked that he was very cross and sullen. Sleep restless, with vivid dreams, but he cannot remember them in morning; urine turbid. Pain in tendo Achillis and os calcis after walking. Pain in left side of face and teeth. (The above symptoms were produced by a single dose. Several other does had a similar effect.) (Ibid.)
14. J C RAYMOND, aet.27, took on Monday evening, Feb. 3rd, 1851, 20 globules of 30th dil. In about an hours had sharp darting pains like electric flashes passing from first phalanx of right ring – finger to middle of forearm, and from lower extremity of left radium up to elbow. Restlessness and sleeplessness during n. from a constant flow of ideas changing from one subject to another. On tuesday an increased flow of saliva; from 4 to 5 p. m., severe pain extending from cartilage of 7th rib at its junction with sternum to right hypochondriac region under inferior border of 10th rib. On tuesday n. he took 40 globules; on Wednesday n. 60; on Thursday n. 5 gr. of 1x trit., and on Friday n. 10 gr. of same with no perceptible effect until Saturday, when there was increased sexual desire with erections, which continued at n., terminating by emission of semen. On Sunday n. took 20 pellets of 30th. Increased flow of saliva during Monday, so much so that when he attempted to speak he found some difficulty from his mouth being constantly filled with saliva. He had some pain of dull character in forehead over eyes, p. m., which became severer in evening and was aggravated by motion. Had occasional pains in left chest between cartilages of 5th and 6th ribs. Tuesday, increased flow of saliva still continues. In afternoon pain of dull aching character in right frontal region, aggravated in evening; also return in evening of pains in left chest in region of heart, of a sharp cutting character, producing difficulty in getting breath while they continued. Wednesday n. – He was awakened several times from sleep by severe pain in right arm. It continued in m., and during day of Thursday, at times very severe, commencing about centre of humerus and extending to elbow and along radius to its inferior extremity; the pain was of heavy aching character, deep – seated, and caused lameness and difficulty in moving arm. In forenoon he had also a return of sharp cutting pains in region of heart, followed by wandering pains throughout whole chest. (Ibid).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.