14. DR. PEHRSON. Great heat in vertex, only objective, all day; at 11 p. m. felt it very hot, and slight pulsation in it (6th d.). Increase of saliva, about noon (6th d.). Weakness in bowels and stomach, partly extending into chest, from 6 a. m. till 3 p. m., feeling as if he would have a stool; during this time had to belch up wind frequently (1st d.). Easier stool, and not so thick as usual (2nd and 5th d.). Awoke from feeling of great soreness in whole breast, but only for a few m. (4th d.). Synovial inflammation of left index; on 2nd day, about 3 p. m., a pricking – itching over right hand, lasted 1 hours, followed next day at 6 p. m. by itching pricking at lower part of upper arm, all around it, lasting 1/2 hours, and same sensation in upper part of upper arm, mostly in armpit, lasted only few m., – all this on right side. (Ibid).
15. Dr. NEGENDANK. Eyes inflamed, particularly the right (8th d.).
16. Symptoms obtained by Drs. Miller and Payne, discrimination being impossible. (See Hering’s list of sources). Heaviness in head, with soreness over the bowels (13th d.); dull heavy pain in head (5th d.); pain and heat in the head; fulness in head (2nd d.); headache, worse in forehead (4 p. m., 7th d.);; headache, particularly in afternoon and evening, with a drowsy stolid feeling in head (3rd d.); violent headache with nausea, from m. till 2 pm., returns in evening, particularly in forehead (21st d.); dull heavy aching pains at base of brain, throat, and nostrils (latter dry); after 2 gr. of 2nd trit, taken in evening, slight heavy feeling right through forehead up to vertex, also same sensation outside skull, next day heavy feeling in forehead all day, more severe than day before, and in evening with severe throbbing in right side of head from front to vertex; slight heaviness, and in afternoon slight throbbing from vertex to nose, right side (6th d.); headache right side, disappearing after rising; heavy feeling outside of skull. Eyes much inflamed, and burn (21st d.); burning in forehead at a p. m., eyes burn and are inflamed till 10, next m. better (4th d.), less inflamed, but weak and hot (9th and 10th d.), this returned (14th d.). A cold in head, disappearing in open air, but returning in warm room, with it a cough from irritation 1st d.). Heavy dull aching in upper jaw, then in lower, mostly on the sides, worse right; he pressed the teeth so much during sleep that the muscles were tired and lame on waking; pain in jaws and temples (7th d.). During dinner pain in all the teeth from mastication (8th d.), the gum of the upper jaw over second right molar excessively tender, as if an abscess was forming, continuing 4 day, on 6th day it had entirely disappeared without forming an abscess; unusual flow of saliva for the first 12 hours, salivation returned later again, constant decided metallic taste; in evening (after 2nd does in m.) metallic taste and taste of iodine; gums feel sore, as if he was going to be salivated. Slight superficial ulcers in throat, in patches; almost constant desire for empty deglutition, apparently from large collection of water in mouth, and from sense of fulness in throat (3rd d.); during eructations pain in region of right parotid gland for 2 hours, for 24 hours there was soreness to touch there. Nausea and sinking at epigastrium, with general sick feeling (13th d.); squeamishness of stomach, with uneasiness and laziness all over limbs, with rheumatic pains, inclination to vomit, and constant strong desire for stool. In region of liver, pancreas, and spleen, heavy painful sensation, which does not continue all the time (13th d.); aching and full feeling in right hypochondrium (3rd d.); sensation like threatening colic, evening till fully asleep (1st d.). Frequent desire to stool, with pain in abdomen; motion in abdomen, and urging to stool, without stool, from 11 p. m. the whole n. through (13th d.); pain in abdomen, with diarrhoea, from 11 p. m. the whole n. through (20th d.). Severe griping and colic pains, forcing him to stool, followed by a very large, copious, but not loose discharge of rather a light – brown colour, could not pass any urine as long as discharge lasted, after discharge urging for evacuation continued, with irritation and itching in rectum and anus, which felt as if it would protrude; about 11 again had severe colic pains, which left him after a pretty loose, light – yellowish brown, somewhat watery discharge, coated with mucus, and of slight bloody appearance; after the discharge a slight tenesmus existed for a time, but colic pains disappeared more and more, only great soreness of the bowels remained; after dinner (2 p. m.) colic pains again returned with a thin loose discharge, and slight tenesmus; in afternoon and evening only a soreness in bowels. Increased flow of urine (3rd, 4th, 5th and 6th d.) In afternoon he felt several times sharp shooting through right side of chest, like rheumatism, going down arm. Aching and stiffening feeling in right splenius capitis (3rd d.). Rheumatic shifting pains, general in limbs and mostly muscular, alternately in arms and hands, legs and feet, occasionally pains of like character in left ear, as if it would be a violent and long – continued otalgia, it lasted only for a moment at a time, but frequently returned (13th d.). Rheumatic pains, soreness and stiffness, in left arm, worse by motion and during middle of day, better in evening, and at n. could lie on the arm; rheumatic pain – more in right forearm and hand, with sense of great weakness, at n. pains got so violent as to disturb his sleep; dull, aching, strained sensation in middle of os humeri as if about to break, wavering stitches through all the muscles, and sensation as if they were sore, desire to stretch limbs and body; aching and drawing pain in bones of left forearm; jerking in fingers of left hand in evening till he fell asleep. At 8:30, when walking, acute pain passed through and around head of right tibia at knee – joint, in 3 or 4 successive throbs, passed off in 5 m., returned in same degree and form, and at same time came in right parotid gland; in 1/2 hours pain in knee disappeared; a throbs of a like pain felt in left rectus femoris, and in 5 m. renewal of similar pain in same place (13th d.). Weariness in m., all day sore pain in left fingers (2 d.); from midnight till m. very restless feeling, with constriction in diaphragm almost like cramp. Nearly a month after the other symptoms, several day after 12th dose, a small pustules on outer side of right leg, just below knee, about 2 in. apart, slightly itching, sore to touch, with inflamed bases; on 3rd day after their appearance they scabbed over, but matter continued to accumulate under scabs; they were quite sore, and were not healed till 13 day afterwards; later, another sore of same character appeared in front of same leg, below knee, which healed in 3rd day, and no more appeared. A wan which had existed behind right ear from infancy, in a young woman of 24, burst open and discharged 19 day after 1st dose, and 11 day after last dose. Very strong itching on neck and dorsum of hands, particularly on fingers of right hand (13th d.). Very sleepy and drowsy in evening, with squeamishness of stomach and great uneasiness and laziness all over limbs (5th d.); sleep disturbed by troublesome dreams, such as swimming and wading in water, and pushing through low places, and under a shed; half conscious sleep with fearfulness, dreamed of detecting robbers in n. attempting to enter dwelling (12th d.); dreams a great deal (11th,12th, and 13th n.). Sometimes a chilly feeling and creeping sensation all over skin, and uneasy sore feeling all over bowels; often felt chilly, and then again quite warm, although his pulse was natural (2nd d.); felt pretty warm all over, but not feverish, sometimes a chilly feeling, and creeping over the back. (Ibid).
17. Dr. RAUE. Dull pressure in cerebellum below occipital protuberance, after awhile pressure over eyes (from inhaling the vapour). Almost constant desire for empty deglutition, apparently from large collection of water in mouth, and from sense of fulness in throat 3rd day. (Ibid).
18. RIESEBERG. (From external application to forehead.). Dull, rending, tearing, gnawing pains in forehead, worse during n., disturbing sleep (3rd d.). Skin on forehead pale reddish colour (1st d.), dirty grey (5th d.), afterwards quite full of the finest wrinkles, peeling off in small scales after 7th day; numerous small cracks and rhagades in all directions on forehead (Ibid).
Experiments on animals
1. A strong male rabbit took, at 8 a. m.,3j along with its food. In the progress of the day, the animal gradually became much enfeebled, evacuating the contents of the bowels, and on the following m. life was found extinct. On examination, the inner surface of the stomach was seen occupied, for about the space of an inch near the pyloric orifice, by some of the poison mixed with vegetable matter, which were washing with cold water would not remove, while the immediate neighborhood presented a crowd of minute yellowish elevations. The general surface of the inner membrane was preternaturally reddened. (COGSWELL, op. cit.)
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.