3b. A dog got 5 gr. crystallized mang. sulph. injected into jugular vein. In 2 m. violent vomiting and at same time normal stool. After 1 m. the vomiting recurred, drank a good deal. In 15 m. was quite well.
3c. A poodle had 12 gr. mang. sulph. dissolved in 3ij water injected into jugular. Immediately lay like dead and breathed deeply. After 1 m. wanted to get up, but fell down again as if intoxicated. Extremities as if paralysed, the anterior first recovered, then the posterior. After 1/2 hours could walk, but was very melancholy. After 45 m. vomited, which recurred after 4 h. Died in n. between 4th and 5th day P. M. -Stomach contained only black mucus, appeared as if mixed with coagulated blood. This mucus was found also in duodenum and a large part of small intestine. The centre of stomach was considerably inflamed, not towards pylorus. Duodenum more inflamed than stomach, the inflammation extended through small intestine, and ceased when the black mucus ceased. Colon only slightly inflamed. Liver covered with inflamed stripes, and the inflammation extended into interior of its substance. In the not inflamed parts the colour was very yellow; this colour was pretty general in intestines and large vessels; the aorta was waxy inside and outside. Gall- bladder contained greenish-yellow bile. Spleen covered with inflamed spots. Both sides of heart contained black, coagulated blood; in left ventricle and round inflamed spot on the partition wall of ventricle several long, inflamed stripes. (GMELIN, Vers. liber die Wirk. des Baryts, &c.) 4. In cold-blooded animals there is produced paralysis of sensibility, reflex irritability, [ “The paralysis of reflex action is due to abolition of the transverse conduction of the spinal cord, longitudinal conduction remaining intact until death (Kobert)” (BRUNTON, op, cit.)] and voluntary movements; the motor nerves and the muscles are unaffected (Harnack). (NOTHNAGEL and ROSSBACH, op. cit.) 5. RABUTEAU injected about 1 grm. into a vein of the hind leg of a bitch. At first there were no symptoms, but on the following day tetanic convulsions set in, and death soon followed. The white substance of the cord was shrunken, the grey matter congested. (PHILLIPS, op. cit.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.