26. a. EICHHORN took, April 16th, 9 a. m., 10 dr. 3rd dil., on sugar. After 5 morning, tension in right temple with occasional shooting in right eye, tensive pain behind right ear which he had experienced for several day came on more violently. Pulse 60, same as usual. 10 a. m., repeated same dose. Soon, diminution of pulse to 52, confusion of sinciput; all went off in open air. – 17th, 4 a. m., 10 dr.; 6 a. m., 20 dr. The tensive pain in occiput very severe, extends upwards and down wards and to both ears. Now and then slight tension above right eye; tension all over sinciput. 8 a. m., 25 dr. symptoms relieved in open air, and tensive pain in occiput recurs in fits. 10 a. m., 15 dr. No new symptoms in afternoon quite well.
27 b. April 18th, 5 a. m., 5 dr.; 8 a. m., 10 dr.; 9 a. m., 20 dr. 2nd dil. During forenoon confusion of sinciput, dull shooting in right ear for some morning – 19th, 8:30 a. m., 10 dr. Heaviness over eyelids, slight nausea, pressure in stomach. 9 a. m., 12 dr. Periodical tearing shooting in both temples, extending to masseter muscles. 9:30 a. m., 20 dr. Tension in forehead increased, with pressure on eyes and root of nose. All went off during day. – 22nd and 24th, 10 a. m., 10 dr. No effect. – 26th, from 8 to 10 a. m., every 1/2 hour, 10 dr., lastly 20 dr. Hot feeling in right cheek. Severe pressive tensive pain behind right ear, increased by pressure, especially when the pressure is removed. Pressive pain in right ear as if swollen; tension in right temple. After taking 20 dr. these symptoms increased much. The tensive pain in occiput extends to deep in neck. Pressure and confusion of whole head. With varying intensity the occipital pain continued all day, did not go off in open air, and lasted till he went to sleep at night. Next morning head was quite free. – 27th. Took 20, then 25 dr. No effect. – 20 dr. Felt nothing but dull tension in sinciput and occiput. 10:30 a. m., 20 dr. Pressure and weight in forehead, dull pain in both ears, over left eye and behind left ear, transient. 11 a. m., 25 dr. Tension in masseter muscles, pressure in sinciput. 11:30 a. m., 40 dr. Occasional shooting in ears, pressure in temples. 12, noon, 30 dr. Shooting in ears increased, great pressure in temples. All the rest of day, confused head alternating with pressive tensive pain, sometimes in temples, sometimes in occiput and ears. Long of falling asleep and frequent waking with severe pains inures, temples etc. Immediately after rising felt quite well. In course of forenoon and also afternoon (29th) occasional pressure in temples, especially right and in occiput. No more symptoms.
27 c. April 30th, 8:30 a. m., 6 dr., 1st dil. For some time burning sensation in tongue. After 1/2 hour pressure in sinciput, especially right superciliary ridge. 9 a. m., 10 dr. After 5 m. slight feeling of nausea, pressure in temples. Pulse 72, small and contracted 9:30 a. m., 10 dr. No effect. – May 2nd 8:30 a. m., 6 dr.; 9 a. m., 10 dr. Shooting and fulness in ears, tension over forehead. 9:15 a. m., 10 dr. Dull tension from behind right ear in mastoid process, in a spot that could be covered with tip of finger, lasts 5 m. 9:30 a. m., 15 dr. Pulse 56, contracted. Pressure, fulness, and weight in whole sinciput. 10 a. m., 10 dr. Severe pressure in forehead and occiput out at ears. In forenoon and in open air occasional dull stitches behind one or other ear, violent pressure in right temple, tension and confusion in whole of sinciput, fulness in head and ears. In afternoon same symptoms but slighter. No more symptoms. (Ibid., 20.)
27. LEMBKE took, May 1st, 3:30 p. m., 10 dr. of a solution of 3 gr. Gl. in 1 drachm alcohol. Immediately great heat all over body, especially in face and head, with profuse hot sweat for 1/4 hour. After a few m. very rapid heart-beats. Pulse about 120, the beating of heart felt in head like a hammer, especially when stooping. Sometimes when stooping such violent shooting in heart that he must rise up immediately. Giddiness, redness, and heat of face, eyes watery. This lasted 3/4 hour. Unsteady gait and palpitation of heart increased by walking. Along with the palpitation pressure in head, especially occiput, this lasted till 9 p. m. ate his dinner at 5:30 p. m. and felt quite well, but the expression of his face was wretched and there were blue rings round eyes. (Zeitsch. f. h. Kl., ii, 121.)
28. Dr. R. DEMME took 2 or 3 dr. of a 1 in 10 solution. It caused tingling sensation in throat and increased saliva. In 10 m. he had giddiness and dull pains in head. On taking 5 or 6 dr. these effects came on sooner, and were accompanied by quivering sensation in masseter muscles. After 10 dr. movements of lower jaw were impeded from contraction of temporal and masseter muscles, and slight twitchings were felt in muscles of extremities. These effects lasted about 1/2 hour, and gradually passed off. (Rep. f. Pharm,., xii, 431.)
29. Eight persons, 5 women and 3 men, after ascertaining their normal pulses during rest, took 1 or 2 dr. of a 1 in 80 solution of Gl. and then counted pulse every 5 m. The pulse of No. 1 sank from 88 to 86, and then to 84. Nos. 2, 3, and 4 showed a rise after 5 m. No. 5 showed first a falling in 5 m. then a rise after 10 m. No 6 showed a rapid fall after 2 m. a rise in 5 m. and a fall again in 10 morning. No. 8, like No.1, after 2 right showed a decline both in 5 and 10 m. (C. WESSELHOEFT, N. A.F. of hours, N. S., vii,6.)
30. a. A laborer drank from a fluid, which he thought was oil, two swallows, but the burning in the throat taught him that he had taken blasting oil, and at the next farmhouse he drank quickly milk and water, and asked for medical aid. He did not feel at time very unwell, but complained only of slight pressure in the chest, accelerated breathing, irritable pulse, off and on some vertigo. After taking an emetic he vomited a fluid smelling and tasting of nitro-glycerine. Respiration became very quick (60); the pulse greatly accelerated (96) but normal; oppression in the pit of the stomach set in; consciousness remained undisturbed, the patient complained of dulness of head, but only once he could not answer when questioned; headache, pains in mouth and oesophagus and thirst were not present, nor mucous rattling of lungs; temperature rather cool than hot. (Leeches to temples and cardia.) At night, about 5 hour after taking poison, vomiting and purging set in, lasting with great severity over an hour; vomited matter had odour of nitro-glycerine; stools were at first greenish, after awhile white, like foam made with soap, watery, and had a trace of the odour. He felt somewhat better; the gastric pains cased; respiration was more quiet, but still superficial, a deeper one following two or three superficial respirations; he complained only of the extremely severe headache; after a while he lay quietly as if asleep; cyanosis and sopor set in, and the patient died an easy death 7 hour after taking poison. Five hour after death cadaveric stiffness was considerable, and froth collected in mouth.
30 b. Post-mortem examination showed a hyperaemic condition of cerebral membranes on convexity and at base; moderate hyperaemia in substance of brain, especially external layer; more internally, brain appeared normal. Posterior part of lungs also showed great congestion. Mucous membrane of trachea was of a reddish-brown colour. Fluid blood in left ventricle of heart, right one empty; coagula in both pulmonary arteries. Stomach contained about 120 gr. of a red-brown fluid; its mucous membrane at the fundus showed reddish-brown injection, with numerous small ecchymoses, swollen to a gelatinous mass, and could easily be stripped off. Nothing abnormal in intestines. (HOLST, Schmidt’s fahrbucher, 1872. H. speaks of four other cases, described in different journals. In all cases severe headache was present, but it set in immediately after taking the poison, whereas in this case it appeared at a later stage; unconsciousness and sopor also only set in before death closed the scene. In relation to the cumulative action of nitro- glycerine, Hystroem found that laborers who have much to do with the blasting oil get a sort of immunity from its noxious action.)
31. Dr. MURRELL prepared a 1 per cent. solution. “Wishing to taste it, I applied the moistened cork to my tongue, and, a moment after, a patient coming in, I had forgotten all about it. Not for long, however, for I had not asked my patient half a dozen questions before I experienced a violent pulsation in my head. The pulsation rapidly increased, and soon became so severe that each beat of the heart seemed to shake my whole body. I was quite unable to continue my questions, and it was as much as I could do to tell the patient to go behind the screen and undress so that his chest might be examined. Being temporarily free from observation, I took my pulse and found that it was much feebler than natural, and considerably over 100. The pulsation was tremendous and I could feel the beats to the very tips of my fingers. The pen Was holding was violently jerked with every beat of the heart. There was a most distressing sensation of fulness all over the body, and I felt as if I had been running violently. I remained quite quiet for four or five minutes, and the most distressing symptoms gradually subsided. I then rose to examine the patient, but the exertion of walking across the room intensified the pulsation. I hardly felt steady enough to perform percussion, and determined to confine my attention to auscultation. The act of bending down to listen caused such an intense beating in my head that it was almost unbearable, and each beat of the heart seemed to me to shake not only my head but the patient’s body too. On resuming my seat. I felt better, and was soon able to go on with my work, though a splitting headache remained for the whole afternoon. ” ( Nitro-glycerine as a Remedy for Angina Pectoris, 1882.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.