1 m. Rare micturition; very scanty urine, only a drop or two, stopping for some time, then recurring with burning in orifice or urethra; frequent micturition, but little at a time;
increased flow of urine.
1 n. Recurrence of menses, which had ceased fro 6 weeks; very profuse menses some days too soon. Leucorrhoea.
1 o. Sneezing; violent chronic sneezing, only during day, chiefly a. m., aggravated to a high degree by strong smells, with irritation in right nostril just above ala nasi, dryness of right nostril, presser in right inner canthus as from a foreign body, making her rub frequently, sometimes dimness like a veil before right eye; this sneezing caused violent tearing frontal headache, very acute stitches in left side, heaviness in legs, general flush of heat. [This observation was made on an artificial flower maker, aet. 19, and was caused by pounding 1/2 oz. of G.; it lasted with intermissions more than a year.] Much nasal mucus of a foetid purulent odour; coryza at first dry, then with excision of ill-smelling nasal mucus; stuffed coryza.
1 p. Scraping in larynx exciting dry cough, night; frequent dry short cough by day; cough, p. m., with some hoarseness and hawking of mucus; cough worst after lying down at night; cough, especially at night, with sore pain in chest; severe dry cough at night, making her sit up; sit up; severe nocturnal cough with secretion of thin mucus.
1 q. Repeated very painful stitches in sternum p. m. and evening; stitches under right mammary region; painful stitch in right side of ribs towards axilla, taking away breath, after carrying a heavy weight; repeated digging and gnawing in both hypochondria, evening; great tightness and heaviness in chest with stitches through to back, especially in hypochondria; heaviness in chest and hence sleeplessness for 2 successive night; pain in chest as if it were all raw inside; pressure in chest; pressure in middle of chest, and stitches from both sides of chest towards one another; sharp shooting under chest (5 morning) then pressure in centre of chest with want of breath (1 hour) gradually going off evening; occasional shooting in fore part of chest, p. m. and evening; shooting deep in fore part of chest, frequently alternating with shooting in right mamma, evening.
1 r. Tearing in nape and left shoulder; sharp shooting in left renal region; shooting in right sacral region; sudden painful shooting in sacral region, relieved by walking about; bruised pain in sacrum as if strained; repeated gnawing in coccyx; occasional shooting bruised pain in sacrum as a if strained; repeated gnawing in coccyx, occasional shooting in top of right shoulder; repeated very acute shooting under left axilla, going off for a short time by rubbing; shooting and numb feeling in balls of right thumb and middle finger, then shooting in palm through back of hand to forearm, with hot feeling; sharp shooting through palm out at back hand then, burning of hands; a violent burning stitch, sometimes in fingers, sometimes in hands, also in ankles, later in whole body; sharp shooting in distal joint of left index; the shooting pains occur or are aggravated evening; tearing in shoulders of axilla, in tendons of extensors of fingers, in balls of thumb or forefinger, as also betwixt metacarpal bones of fore and middle fingers, so that the skin was drawn in by the pain; pinching in right arm-bones; itching of ball of left thumb. Violent sharp stitches in left groin (1 hour); repeated shooting in left calf; violent shooting in right sole, going off by rubbing; some stitches under right big toe; severe tearing in left hip; frequent drawing and tearing in left groin; tearing in bone from middle of right tibia to above knee; tearing and drawing in tendo Achillis as if it were shortened; cramp and tearing pain in calf with drawing in of toes, removed by strong friction; cramp-like tearing in the 2 small toes of right foot; cramp in right big toe, removed when walking and in bed evening; painful cramp like contraction on right outer ankle and in big toe, making him limp when he walks; painful pinching in dorsum of right foot towards toes; violent bruised pain under left patella, when pressed the foot pains as if ulcerated; violent pain and stiff feeling in right leg along tibia, only permitting foot to be stretched out by a great effort, p. m. and evening in bed; pressure as with hand above left outer ankle, and gone-to-sleep feeling there, going off on treading;great weight and weariness of feet. (Noack and trinks’ Handbuch, i, 801.)
2. a.L. RICHTER finds that, taken in small doses, G. acts as a stimulant to the abdominal organs, augmenting the secretion of the glandular apparatus; in larger doses it purges, generally causing severe colicky pain and tenesmus, and often vomiting besides.
2 b. RAYER observed effects of g. upon persons who either had no acute disease or where convalescent from sickness. It was first given to 15 persons in doses of 5 gr. each. All vomited bile within 1 hour or 1 1/2 hours, and had from 2 to 6 stools, with little or no colic. There were no symptoms of local inflammation or general fever. A reduced dose of 3 1/2 gr. was afterwards given, and occasioned slight nausea, but no vomiting, and 2-6 stools, with slight colic or none at all.
2 c. When G. is treated with alcohol there remains undissolved a gummy residue of a bitter and acrid taste, but, according to Krahmer, without sensible action on the intestinal canal in doses of 35 or 40 gr. The alcoholic extract, on the other hand, which constitutes 85 per cent of the original mass, is purgative in a dose of 4 gr., and in Krahmer’s experiments on himself it did not occasion nausea, but moderate pain in colon, and produced two large faecal and mucous stools. (STILLE. op. cit.)
II. A barber-surgeon administered 3j to a patient, which produced violent vomiting and purging, with fainting and other accidents. The patient did not die immediately, but after some time and much suffering perished. (Ibid., from PAULLINUS)
III. The effects Of. vary considerably in different animals, and also in the same species, according to dose and mode of administration. Flohrmann found that 15 gr. given to a horse 2 years old produced malaise, agitation, a frequent pulse, twitching of muscles, distension of abdomen, thin alvine discharges, and trembling of whole body. Viborg gave 3j to a 9 mo. foal, producing 11 evacuations within 4 hours, while a like dose administered to a horse had no effect water. The last-named experimenter, and also d’Aubenton, found that sheep were purged by 20 – 60 gr., and that 3ij were often fatal. Drachm doses caused vomiting and purging in dogs. In an experiment of Orfila’s 3ss caused efforts at vomiting, but did not purge, and animal died within 24 hours without any active symptoms whatever. In such cases the m. m. of the stomach, and also that of the rectum, was reddened but not disorganised. When finely powdered and applied to a wound in considerable quantity, G appears to produce local inflammation and death without signs of pain and without vomiting or purging.
These experiments are very far from rendering clear the; modus operandi of G. The immediate phenomena, both local and general, and the lesions found after death, are in-efficient to explain the fatal result. Few of the symptoms which a local irritant produces are displayed; there is but little expression of pain, and seldom either fever, convulsions or coma, so that the action of the medicine must be regarded as very obscure, and different from that of the drastic purgatives with which it is classed. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.