3 c. January 2nd, 1884, began again taking drug in same way, but was obliged to discontinue it on 6th day, because of the intense itching developed. This was felt chiefly on lower extremities, but somewhat on abdomen, head, and back. No other symptoms noticed.
3 d. January 24th, itching having entirely subsided, began taking 2 gr. of 2x trit. morning and evening, and continued this for 10 day 25th. – Slight inability to fix thoughts, soon overcome by will; great appetite; slight itching. 26th. – Woke in morning unrefreshed, from laborious dreams. Some return of previous pains, fulness in vagina, and hunger. Burning spot on left sole when shoe was removed at night, also for a little while next morning 27th. – Some pains and itchings. 28th. – General malaise, tired and stupid feelings, wearing off towards evening. Again burning spots on feet and tenderness of callosities. 29th. – Woke with dull headache, which continued all day; irritable, stupid, forgetful, unable to comprehend; tongue yellowish at base, papillae raised, and bright pink anteriorly, with bitter or bloody taste in mouth; itching and hunger as before. 30th. – Woke tired, and continued so all day.; tongue same; occasional pains; burning spots and itchings as before 31st. – Same in all respects; easily moved to tears or laughter; itching intense February 2nd.-Sharp stitches in various parts, especially left temple; itching almost unendurable on thighs; felt hurried and energetic all day. 3rd. – Same.
3 e. March 17th, took same for 6 days. It brought back similar symptoms to those of former occasion, viz. some headache and backache; tired feeling; burning spots on feet and itching there and elsewhere; sharp pains at various parts, especially temples; pressure and fulness in vagina; dulness of mind; shortness of breath on slight exertion; intense hunger about 1 hour, before meals; uneasy unrefreshing sleep; sore or “lame’ spots in flexors of left forearm. (Ibid.)
4. Mrs. R. A. LAWRENCE. a. September 1st, 1884, began in evening course of 8 powders of 4x trit., one night and morning. 2nd. – On rising slight stiffness of muscles of right neck and shoulder, lasting till 6 p. m. 3rd. – Nausea after evening dose for 1 hour. Broken sleep during night. No other symptoms. 6th. – Began this evening course of 9 powders of 3x. 7th. – Sleepless after 2 a. m. After 3 p. m. dull frontal headache with feeling as of weight over eyes. Till 6 p. m. temperature 99o, pulse 76; later both normal. – 8th. – After breakfast sense as if band were about head, and heavy tired feeling from hips to knees. Former better by 10, but latter remained all day. 10th. – Languor and heaviness in legs when in motion for 3 hours 10th. – Pain in right abdomen, near hip while walking; pulse and temperature somewhat above normal height.
4 b. 22nd. – Began course of 10 powders of 3x, 2 gr. each, one night and morning. No effect save dull frontal headache and heaviness of limbs on 1st day, and occasional slight nausea on
3rd. On 30th began course of 9 powders of 2x, 3 gr. each, as before. October 1st-Slight pain in left head, extending to forehead; pain in stomach, quite severe for a time. 2nd. – Early in morning stiffness and drawing of muscles of right neck; later, fulness and distensive pain in stomach; occasional flushes of heat during day. 3rd. – In morning darting pains in abdomen; slight nausea. At 10 a. m. pain in left shoulder, running down to elbow; heaviness of legs, right feeling almost useless; at night pain in left head extending over both eyes, with weight at occiput; pain in abdomen near right hip; could not sleep till 1:30 a. m.; following night also very restless. Flushes increased on 4th, and lasted till 6th. 7th. – Took 7 doses of 5 gr. each at 3 hours intervals. Flushes increased in frequency, and persisted up to 9th. 12th. – Took similar dose every 4 hours. Drawing pains in back of head, and stiffness of muscles of back of neck came on in night; nausea and salivation next morning head feeling large and confused, with oppressive pains on its left side, slight pain in left leg, aching between shoulders up to neck. Dull pains through top of head, relieved by pressure. 19th. – Began at 7 a. m. to take 6 gr. every hour. After 4 doses slight pains began in left head and dull pain in forehead, with nausea and increased saliva; aching of thighs from hips downwards; puffiness under eyes. P. m., after an interval of 3 hours took 5 more doses hourly. Dull heavy headache, nausea increased; palpitation on lying down at 4; pain in both shoulder-joints; on lying down in bed heart-beats quickened immediately; at same time head felt full and large, and as if band were about it, with aching and pressure at vertex. On rising next morning weak heavy feeling of limbs, relieved by exercise. November 1st. – Took during day 7 powders, each containing gr. 1/16 of C. Heaviness of head with sleepiness all forenoon; p. m. sharp pains in right hand and arm, and over right shoulder and hip; pain in left head and temple; greet increase in urine. 2nd. – Took similar powder at 6:30 a. m. During morning looseness of bowels, with slight pain at time of stool; urine copious and urgent, bladder feeling distended. 16th. – Menses having appeared on 13th, took powders containing each 1/8 gr. every 3 hours till 2 p. m., then every hour till 10. Flushes came on in morning; sleepiness; pain and heaviness of legs; pain in left head, extending over top, with dulness and heaviness at back; discomfort in abdomen with pain in right side near neck; catamenial flow scanty during day, profuse and bright at night. 17th. – On rising, muscles of right neck stiff. Menses as yesterday. December 30th. – Received 10 powders (each containing 1/8 gr.) to be taken twice on 1st day, 3 times on 2nd, and so on till used up. 31st. – Pain in grow low down, with heaviness in limbs while walking. January 1st stiffness of right cervical muscles all day; frontal headache; pain in right iliac region as before; nausea after retiring 3rd – Dull headache in forehead and eyes in morning; uneasy feeling in bowels; at 5 p. m. nausea and headache, heaviness at occiput; flushing in evening. 10th. – Took powder, gr. 3/16 every 3 hours. Nothing but nausea, heaviness of limbs, and slight headache as before. ( Ibid.). [it is noted that this prover was less sensitive than the others, less imaginative also of calm and strong mind, and sturdy physique.- EDS.]
5. a. During August, 1884, I experimented with c. I commenced with the 3x trit. 2 gr. 3 times a day, continuing this for one week. The only symptom noticed was a ringing in the ears; this occurred several times, at different hours, and was at times prolonged and metallic. The dose was increased to 5 gr. 4 times a day; but, as no other symptoms showed themselves, after a few day. I took the 2x in same way. Once or twice again I noticed th ringing, sometimes only in one ear, and this was the only symptom produced. At the time I was extremely fatigued from long- continued overwork.
5 b. After a season of rest, during which my health greatly improved, I made fresh experiments. February 5th, 1885, took 5 gr. of 3x, without effect. 12th. – Three doses of 10 gr. each; no result. 13th. – One dose of same, 3 to 10 gr. or 2x. Two hour after 1st of these ringing in right ear. 14th. -Three 10 gr. doses of 2x. Ringing in right ear noticed once; about 5 p.. slight dyspnoea (not worse for running) for 15 – 20 morning 15th. – Took one dose of 10 gr., and 2 of 15 gr. each without effect. 16th. – Took in one dose all he had left, about 31 gr. About an hour after sharp pain in front of left ankle, as if joint had been wrenched or “turned” (which it was not). No other symptoms. (J. P.UTHERLAND, M. D., Ibid.)
6. At leisure hours I took C. from the 4x trit. down to 1/5 gr. doses, repeating each trit. 5-7 times before proceeding to the next in strength, and always allowing an interval to elapse to make sure of the expiration of drug-effect before taking the drug again. During all these weeks of proving and watching for effects, I am quite sure that none whatever occurred except after doses of 1/5 gr., after which thee was – twice only – a feeling of constriction of head, and of occipital pressure, lasting about 20 morning. None of the functions were disturbed at other times; in fact, I never was reminded, by any ill-feeling whatever, of having taken a medicine. (C. WESSELHOEFT, M. D., Ibid.).
Poisonings
PREYER has observed, as effects of triturating the poison, rush of blood to head, with transient but very violent headache; increased secretion of nasal mucus and salvia; bitter taste; remarkable weariness. From getting a few drops of solution into a cut on the finger, lachrymation; constant flowing of nasal mucus;mouth unable to hold saliva; a very unusual secretion of urine; the whole body covered with sweat. As effects of emanations while evaporating a solution, headache.
Experiments on animals.
1. a. When small quantities are injected into veins, subcutaneous tissue, or lymph-sacs, or applied to a wound, certain uniform effects are produced. The animals sink down and die without convulsions. First the head falls, and then the limbs give way. Respiration grows weaker, and soon sees. The animal is incapable of voluntary motion, an does not react upon painful irritation. The heart continuous to beat vigorously in frogs even for day, while in warm-blooded animals it ceases somewhat it ceases somewhat sooner, the mucous membranes becoming livid, and dark colour of blood indicating death by asphyxia.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.