15. Dr. LEMBKE, 20th Feb., 9 a.m., took 20 drops of a solution of 1 gr. in an ounce of water. 21st, 8:30, 30 drops. Almost the whole day pressure and heaviness in forehead, heaviness over eyes, which were not freely opened, aggravated by stooping. Towards evening this pain abated. About 10:30 p.m., whilst sitting, suddenly on r. parietal bone a violent drawing upwards; immediately after pressure in l. side of forehead, then deep in the r. wrist, drawing in r. side of lower jaw and r. knee. Today (22nd) whilst walking, several times a sensation as if the heart beat once or twice stronger, without however any hindrance to the walking, or any oppression of the breathing. 11 p.m., drawing in r. toes, strong pressure at the top of l. shoulder when the arm was at rest; drawing in the l. toes, and flying about to the parts named, noticed first after 10 p.m., not during the d. Drawing in the middle of lower edge of r. orbit, then in lower jaw both r. and l. side, in lower molars, then in the forehead. Urine dark yellow, acid. Shooting pains round about r. olecranon, rather violent and lasting; neither movement or elbow nor pressure had any influence on the pain, but it was somewhat increased during rest of the joint. 23rd, 8 a.m., 30 drops. Tearing in l. side of forehead, inside l. knee, then in r. knee. 8:30 a.m., sensation in upper part of l. forehead like a moving about in the skin. 3 p.m., pressure in l. shoulder-joint. 4:30 p.m., the beating in the forehead as before, lasted 1 h. Drawing on under edge of r. orbit at 5 p.m. and again at 9:30. Pressure in l. wrist at 10:30 p.m. 24th, 6 a.m., pain in l. side of forehead as above. Tearing in internal aspect of elbow. Pressure in r. temple. 8:45, 30 drops. Pressure in r. temple. 10:30, frequent micturition. 25th, 8 a.m., a teaspoonful of above-named solution. Pain in forehead as above. 9 a.m., drawing in l. hand. About 4 p.m. another teaspoonful; pressure in lower edge of l. orbit, and, 5 p.m., several times in r. wrist. March Ist, a teaspoonful at 7 a.m. 8 a.m., pain in forehead, as before on l. side. Weight and pressure in fore part of head, lasting whole day, apparently worse on going into open air, leaving off towards evening, not aggravated by eating. 9 p.m., violent shooting in inner canthus of r. eye; during the forenoon it seemed to me that I passed urine more frequently and more copiously, which was darker yellow than usual, especially in proportion to the quantity of fluid drunk. In evening, on the other hand, there was strikingly little urine, contrary to habit. On 2nd, at 4 a.m. and 6 a.m., urgency to urinate, with very little urine, which was dark yellow. 4th, 8 a.m., a teaspoonful. Drawing in skin of forehead in l. side; in skin of left cheek sensation as if a spider’s web lay on it, which was repeated. Pressure on r. side of top of forehead, and in right nipple from within outwards. 9 a.m., violent pain in left wrist. About 9 a.m. strong urgency to micturate; urine copious, bright yellow; weight and pressure in forehead lasting all day 8th, 3 p.m. (3 h. after food), 1/2 a teaspoonful of 2 gr. j in 3j of distilled water. About 6 p.m. drawing in skin of l. cheek and in l. side of the forehead. 10th, 6:30 a.m., 1 tablespoonful. Drawing in skin of both cheeks. 7 a.m., tearing in r. tibia and, 8 a.m., behind r. ear. About 9 a.m. very tired and sleepy. Pressure in l. eyebrow. 11th, 7 a.m., a teaspoonful. Pressure in r. knee 8 a.m. Boring deep in r. orbit on lower edge; pressing drawing through the whole r. arm 8:30 a.m., sometimes more violent on back of hand or in upper arm; then prickling in sole of r. foot while sitting. Pressure in left side of frontal bone, especially on frontal eminence, sometimes stronger, then slighter; this pain persisted, changing sometimes into sensation as if there was a band over forehead, aggravated by motion. Sticking in point of l. little finger. 9 a.m., drawing in front of l. leg. 1 p.m., pressing together in the whole l. leg whilst walking. Violent boring in l. forehead whilst walking at 1:30, and directly after feeling of pressure on chest, without palpitation, causing him to take deep breaths, lasted 1/2 h., came and went whilst walking, returned an hours afterwards, also whilst walking, but only lasted a short time. During the whole day has passed urine more frequently and more copiously. 9 p.m., sticking in knuckles of third r. finger and on back of foot. Pressure in l. side of the forehead, drawing in l. cheek. In evening unusually great hunger which could not be appeased; also in m. of 12th. In n. of 11th micturition three times, much urging thereto, but little urine about 5 p.m. 12th. – Violent pressure in r. knee, also whilst walking, lasted an h., then shooting pain deep in tongue, lasting about an h. 10 p.m., tearing and pressure in middle of lower edge of r. orbit in several attacks whilst sitting; touching or pressure has no influence; at same time much thin saliva in mouth, and again shooting deep in point of tongue with a bitterish taste or like soap and water. Thereafter pressure anteriorly in under part of r. leg, and then the same pain in the r. orbital edge, either at the same time or alternately with the shooting in the tongue. After this pressure in l. ankle, then on back of r. foot, immediately after the former pain in orbital edge. 11 p.m., whilst sitting, these pains were repeated several times, then drawing in all teeth of under jaw, but pain always went by preference to, and was most frequent and most violent at, the lower edge of the r. orbit; this last pain remained when I went to bed at 11:30. Suddenly, whilst lying quite on the back, pressing in the throat and violent, short, dry cough without tickling in the larynx; after this I soon went to sleep. Woke in n. through urging to urinate, felt the former pain at the orbital edge, but the cough did not recur at all. 13th, 7 a.m. Whilst sitting, drawing in l. instep. 8 a.m., a teaspoonful. Boring in left frontal eminence. 8:30 a.m., drawing across whole forehead, lasted to-day only a short time. Early urging to urinate, 8:45. About 3 p.m., whilst walking, sensation of pressure in region of heart without palpitation or cough; it was not necessary to stop whilst walking, but only the need of breathing deeper occurred, and the same condition remained on one occasion after I was resting quietly in my room. 15th, 8:30 a.m., 2 teaspoonfuls. Pressure in r. knee whilst sitting and walking, and on back of l. foot. Drawing in r. fingers. Pressure and drawing across forehead and beneath l. eye. During whole day pressure and weight in front of head, worse on stooping. Strong pressure anteriorly in r. leg, later in l. knee, 6 p.m. At 9 p.m. drawing through lower incisor teeth, not made worse either by cold air or warm drink; then drawing in upper part of chin, under the skin. 16th. -After rising, drawing internally in middle of r. upper arm, then in muscles of r. thigh, interiorly and internally. 6:30 a.m., 2 teaspoonfuls. Boring in upper half of l. eye at 9 a.m. and later. Drawing in l. knee. To-day and on 17th, here and there as if a plucking, only always in little spots, of upper arm or thigh, behind ear, on l. cheek, burning in tongue, on a little spot of back of one or other hand, on inner protuberance of knees, whilst sitting and walking equally frequent. For several d. I have been two or three times to stool daily; the stools were softer than usual, no difference having been made in the manner of living. 17th. -At 1 p.m., whilst sitting, violent shooting and tearing below l. internal ankle, making me get up and walk about quickly, with which the shooting and drawing gradually passed off. At 5 p.m. same pain returned but less strongly. Later, drawing on back of l. foot and in second joint of left forefinger. At 8:30 p.m., whilst walking, the drawing under the left inner ankle came again very painfully, also passing off during walking. In n., on waking, the same sticking in circumscribed spots of limbs. The same happened also on 18th on little isolated spots of head early in m., about 1 p.m. Strong boring, increasing by fits and starts, at the top of right side of head whilst walking, also on one quite narrowly-bounded spot; the same in left temple at 10 p.m. whilst sitting, and after 1/2 h. in r. temple. Somewhat later, the same pain more to the left in the forehead. 19th, 6:30 a.m., soon after rising the same pain above left ear. 8:30, strong pressure in pit of stomach for a few m. and immediately after pressure on back of r. foot. Drawing in l. thumb and on back of r. hand. In course of day same pains in head as yesterday but less strong, also the plucking in circumscribed spots in the limbs. On 20th, 21st, and 22nd, before 6 a.m., I awaked through sudden call to stool; the evacuations were copious, bright yellow, half liquid, without tenesmus; and soon after the same necessity occurred again, sometimes without result, besides two stools daily; no alteration being made in the diet; the appetite might be called slight. The plucking in various circumscribed spots of the limbs and head occurred on these days also. 23rd, 9 a.m., a bright yellow, copious, semi-fluid, peculiar evacuation. 27th, 8:45 a.m., 2 tablespoonfuls of a fresh solution of 2 grains to the ounce of distilled water. Between 11 and 1, whilst walking, sensation of trembling at heart without obliging me to stand still, without shortness of death, occurring several times. About 12, whilst walking, pressure on a little spot on back of l. foot, which also passes off whilst walking, without being increased by any motion of the foot; about 1:30 the same sensation whilst sitting. Repeated severe drawing in lower incisors whilst sitting, not aggravated by anything. In n. and on m. of 28th frequent need to pass water, which was darker than usual and only passed in small quantity. 28th, 8:30 a.m., 2 teaspoonfuls. At 9 a.m. pressure in l. forehead and right knee; boring in frontal bone. Shooting in point of tongue, repeated several times later. Frequent urging to urinate the whole day. Tearing on l. side of skull at 5 p.m. and in r. instep. Frequent pinching in inner corner of both eyeballs. About 8 p.m. boring on lower edge of left orbit, then strong pressure on one small spot of r. shoulder. About 9:30 p.m. boring at both sides of glabella, then drawing in l. toes. 29th, 7 a.m., boring in l. temple, l. side of forehead then right, recurring several times during day 8 p.m., violent boring in l. temple, 10 p.m. in l. shoulder-joint, worse by moving it. 11 p.m., in bed, violent boring in l. temple and l. frontal prominence. 5:30 a.m., the same in bed and after rising at 6 a.m. 30th 7:30 a.m., 2 teaspoonfuls. Since yesterday I noticed in the l. wrist, on bending it, leaning on it, &c., a tension and stiffness with a deep-seated pain, disappearing towards e. 7:45 a.m., a slight stool, but much passage of mucus from the rectum. Dull pressure in r. ankle and upper half of r. patella. 8 a.m., whilst sitting, tearing in l. frontal eminence, then on r. cheek. Drawing through end of urethra. 8:30, creeping in skin of l. cheek. Drawing in left toes, on r. side of skull, in l. shoulder, in l. frontal eminence, which recurred several times during day 7 p.m., whilst walking, violent pricking in small spot now over, now at side of r. knee, seemingly in the skin. 9 p.m., pains through joints of l. forefinger, increased by bending finger, with which a difficulty in moving joints was experienced as from swelling, which also lasted till m. of 31st. 31st, 7 a.m., 2 teaspoonfuls. Frequent shooting in r. eyeball, tearing on r. side of skull in various small circumscribed spots. 8 a.m., pressure in l. knee and r. ankle whilst sitting, later in r. thigh. Boring in r. temple 9 a.m. All these pains recurred often during d. At 2 p.m., whilst sitting, the above described sensation in heart. April Ist, 6 a.m., on rising head heavy, and tearing in it as yesterday. 8 a.m., tearing in l. ankle. The urine passed at noon is slimy and turbid, and the vessel, as far as the urine reached, was coloured with a red coating; the urine passed at 5 p.m. is clear and yellow. On all these day stool twice daily, in other respects not unusual except that it was softer. 2nd 7:30 a.m., drawing in left shoulder. l. side of head, and forehead. 8 a.m., 1 teaspoonfuls (completing the ounce). Drawing anteriorly and interiorly in r. leg whilst walking, tearing in r. frontal bone. As previously the pain was confined to one small spot. The affection of the l. index finger noticed on March 30th lasted till to-day. Boring in r. temple; shooting in tip of tongue, 9 a.m. 2 p.m., violent boring above l. eyebrow. In l. cheek a wandering pain like a creeping. 5 p.m., wandering boring in upper half of forehead. Drawing through l. lower limb whilst sitting, and in l. little finger, which is painful when moved. 11 p.m., violent boring in l. temple, then the same pain, but constant, two or three fingers’ breadths above right ear. In evening pain in l. forefinger had almost entirely ceased. 3rd, 7 a.m., small, hard stool, but much mucus from rectum. Drawing in l. toes. Shooting in tip of tongue. Boring in temples and head as yesterday, and in evening violent drawing through whole r. lower limb whilst sitting; whilst walking, in left calf a peculiar sensation like shooting, also like a hot fluid running over the skin. 6 p.m., drawing through lower incisor teeth with a sensation of their being raised. 4th, in m. on rising, tearing on top of head, and about 8 a.m. a stronger tearing across skull. Drawing in knees and right thumb. Boring in frontal prominences, fore part of head heavy. Tearing here and there in forehead all d. If pain in head ceased for any time, drawing occurred in the finger-joints, or in one knee, or in a little spot on r. upper arm a plucking as before described, or a similar pain in one leg. On all these days frequent urging to urinate. Towards 9 p.m. pains in forehead ceased, has remained here and there in limbs. 10 p.m., violent shooting in r. eyeball. In l. arm much pain on bending it or leaning on it, as on a former occasion, recurred again on 5th. Violent shooting in right eye on 5th. 6th, 11 p.m., 1 tablespoonful of a 3 grains to the ounce solution. No pains. 7th. -On rising, heaviness and pressure in forehead, drawing on l. cheek, boring in l. frontal eminence, drawing in r. toes and r. forearm. 8:30 a.m., 1 tablespoonful. Anteriorly and interiorly in r. leg, pressure on one circumscribed spot, several times; then in l. inner ankle, and in l. shoulder. Boring in l. frontal eminence, in head two fingers’ breadth above the right ear, and in r. shoulder. 12 noon, much clear urine, frequent urination. Whilst walking a pressing pain came on in the soft parts below and in front of l. trochanter, which when stepping caused the joint to bend under him, which did not recur at each step, or each movement, yet happened very frequently. Boring in r. upper orbital edge. 3 p.m., whilst walking, pain in l. calf as in cramp. Shooting in l. cheek several times, in point of tongue, and in left toes. 8th. -Before taking dose some pains in cheeks, ankles, and shoulders. 7:30 a.m., a teaspoonful. 9 a.m., shooting and drawing in l. cheek. Drawing in outer edge of r. foot and l. side of forehead. Pressing in l. wrist and r. knee, equally strong whilst walking or sitting, also frequently later in the d. Violent boring in l. temple at noon. Frequent shooting deep in l. ear. Whilst walking, on outer side of l. calf, in a small spot, violent pain compelling him to bend the leg; also, whilst standing, same pain; it lasted a few m. and then went away entirely. Violent boring on r. side of back of head; 4 p.m., in r. shoulder. Drawing in r. fingers. 7 p.m., urging to urinate, copious bright-yellow urine. Oppressive feeling at heart without dyspnoea; even quick walking is quite possible without causing aggravation. 9 p.m., whilst sitting, same violent pain in outer side of l. calf. Strong shooting deep in l. side of chin, then through the right molar teeth, then in upper back teeth. 10 p.m., whilst sitting, strong pressure in soft parts above r. knee- joint, in l. little finger and back of r. foot; these were all repeated. 11:30 p.m., in bed, the pain over the knee-joint, also the following m. on rising, and subsequently. 9th, 7 a.m., drawing, anteriorly and interiorly, in l. leg, in under part of l. forearm, in several finger-joints, in l. side of forehead, and joint of l. knee, equally strong whether sitting or walking; also frequently recurring later. Boring in upper and lower r. orbital edge, later over l. ear, and higher up. Here and there creeping drawing in skin of front and l. side of nose. Otherwise the same pain as yesterday. 10 p.m., burning in tip of tongue, and a peculiar bitter (but not that of arg. nit.) so long as the burning lasted. 10th, 6 a.m., on rising, much shooting in left eyeball, more especially in its under part. 8 a.m., boring on r. side of top of head. Drawing on r. cheek. Boring deep in both sides of chin. The heart affection was frequently to-day as yesterday. In general to-day weariness and heaviness of limbs. Much inclination to fall asleep whilst sitting, also yesterday. Two or three liquid stools daily, much mucus. 11th, 8 a.m., very violent and lasting pains, shooting and beating, in tip of left forefinger for 5 m. Boring in l. frontal eminence. In evening some pains in limbs. 12th, 5:30 a.m., in bed, violent boring in l. outer ankle, and in l. shoulder at 8 a.m. in left shoulder, at 8 a.m. in r. side of head and l. wrist. The heart pain as on former days. Violent shooting and drawing in right toes. Violent tearing on head, now on r. side, now on l., also at 11 p.m. on l. frontal eminence. 10 p.m., indications of the pain so powerfully felt behind and below inner l. ankle on March 17th. Drawing in back of foot and in toes of l. side. 11 p.m., strong boring in r. upper orbital edge. 13th. -Much weariness and inclination to sleep whilst sitting; also former pains. The same on the 14th. 15th, 8:30 a.m., 1 teaspoonful. Boring in r. elbow; burning in tip of tongue; pressure and drawing in l. frontal prominence, l. ankle, in soft parts of one or other thigh, always in the small spot; drawing in the l. toes, in one little spot of one or other calf, pressure in front of l. knee, in various parts of dorsal muscles, and on top of shoulders. Also whilst walking pressure in knee came on stronger whilst stepping; the pains generally came on whilst sitting as during motion. Drawing on l. cheek and top of l. side of the head. Several times shooting in l. eyeball. Boring in r. upper orbital edge and on frontal bone. These pains were felt the whole day with little intermission, always in the same circumscribed spot. In n. many dreams (which seldom happens with me) of places where I was once, of persons whom I likewise saw once; everything relating to time and proportion was tangled and confused. 16th-Before taking the dose some of the above- mentioned pains. 8:30, 1 teaspoonful. 9 a.m., on l. side of the top of the head a drawing like a creeping prickling; then same in front of and over the r. ear. Drawing and pressure in frontal bone, in several spots of one or other forearm, also in one leg, and in r. side of nape of neck below hair border. 3 p.m., persistent tickling in larynx; inspiration did not increase it, but rather seemed to lessen it; short dry barking cough, scarcely ever ensued whilst sitting; I had not been speaking continuously or anything of the sort. Drawing on l. side of top of skull, extending downwards to above and behind the l. ear; pressure did not aggravate it. 4 p.m., shooting in knuckles of r. hand. 17th. -Several of the above symptoms. Burning shooting in left zygoma, then in right, at 5 p.m. on outer edge of l. orbit. Shooting in tip of tongue, also in evening 6 p.m., strong boring in r. temple. 9 p.m., prickling deep in r. ear. Strong tearing and boring in upper part of forehead on l. side, and l. zygoma. Pricking in l. inner canthus. In first part of night restless dreams of long faintly illuminated walks, along which glided peculiarly clothed figures, which on my advancing to meet them receded, and on my retreating followed me at same distance. On waking, tearing on one side of head. 18th, 7 a.m., tearing on l. side of head, on back of r. foot, and on lower and fore part of r. leg. Pressure on r. wrist. 8 a.m., 1 teaspoonful. Boring in temples and left frontal bone; pressure in knees on sitting or walking. The former pains: pains in joints, soft parts of arms and legs, always in single isolated spots. 19th, 6 a.m., in bed, tearing in head, in temples, and in first phalanx of. forefinger. Boring in back of r. foot, directed inwards whilst sitting. 8 a.m., 1 teaspoonful, which completes the ounce. Boring in temples and shoulders; shooting in zygomas, drawing behind and below r. inner ankle. 9 a.m., the former pains are repeated, especially much drawing in fore part of head with pressure and heaviness, lasted several h., equally severe whether sitting or walking; also at 11 p.m. some pains. Stool all these day normal. General health undisturbed. 20th. -In m. languid, great inclination to rest. 8 a.m., from right nostril a few drops of blood came out without blowing, touching, or moving it, or anything of the kind. Pains in forehead, cheek, and limbs; much yawning and sleepiness in forenoon; frequent shooting in meatus of urethra; also 11 p.m. in bed. Violent pressing in lower and anterior part of r. leg. 21st, 6 a.m., in bed, violent boring in r. frontal eminence to side of head; shooting in tip of tongue several times. The former pains, but moderate. 22nd, 8 a.m., one teaspoonful of fresh solution of 3 grains to the ounce. Even before the dose, some pains in the toes and knees, shooting in tip of tongue; violent shooting deep in right ear and around it at 10 a.m. Pressure in front of r. knee continued, appearing and vanishing whilst walking. 2 p.m., drawing pain in little spots in soft parts of thighs and calves, especially in upper part of l. thigh; also on m. of 23rd. 23rd, 8:30 a.m., 1 teaspoonful. Boring on both sides of l. tendo Achillis; frequent urging to urinate and shooting in tip of tongue; drawing in r. upper teeth 5 p.m. several times, also in lower r. back teeth; cold or heat had no effect. Towards 5 a.m. violent pricking in rectum, which recurred on 24th after rising. Boring in r. ankle, in l. upper orbital edge, in front of the left ear and in several finger-joints. 25th-The same. 26th, 8 a.m., a teaspoonful. The same pains on the frequently indicated spots. Stool since last mention always slimy. In evening and in m. of 27th, in bed, some pains in limbs and head. 27th, 8 a.m., 1 teaspoonful. Before dose boring and tearing in several spots of leg, fingers, forehead, and sides of head. Shooting in l. eyeball. Remarkably violent pressing at same time in both elbow and into the forearms, 9 a.m. Boring in frontal eminences, zygomas, and knees, as before, behind and below left inner ankle, whilst walking at noon, more violent than the last time. Violent lasting shooting in the last phalanges of the l. forefinger; later the same in the first r. toe. Towards e. on two occasions palpitation by movement of the body. 28th. -The same pains, only feebler, especially in the e. for several h.; much shooting and burning in the r. eyelids. 29th, 8:45 a.m., 1 tablespoonful. Just before taking dose pains in the joints and face. Otherwise the same pains as on the 27th. 30th, 8:30 a.m., 2 teaspoonfuls, which completed the ounce. Boring in r. lower orbital edge and behind and below l. inner ankle-bone whilst walking, 9 a.m., with which the pain, so to say, was felt in the heart, and in the chest a kind of unrest arose which absolutely compelled me to walk about; the same took place at the other times when this pain occurred. Palpitation and feeling of uneasiness in heart, as well when standing as in gentle motion, several times. Frequent urination. Shooting in r. eyeball, 4 p.m., afterwards the other pains in limbs and tip of tongue. May Ist. -Marked boring in circumscribed spots of single joints and soft parts of limbs, in forehead, and side of head. Strong scent seemed to increase considerably these head pains. 2nd-Same pains, especially boring in several parts of head. 3 p.m., tickling in larynx and spasmodic cough. 3rd. -Same pains; also pressure in stomach in several attacks without any known dietetic cause. On all these d. frequent urging to urinate with copious urine, bright yellow and acid. The quantity is considerably increased compared with the fluid imbibed. 4th. -The same pains. May 5th, 8:30 a.m., 1 teaspoonful of a 4 grains to the ounce solution. The same pain. 6th, 3 p.m., a teaspoonful. Urine not increased. 7th, 3 p..m., 1 teaspoonful. After this marked frequency of urging to urinate; urine copious, yellow; after urinating cutting at meatus of urethra. Frequent palpitation on slight agitation and also by more rapid movements. After this the former pains. 8th. -The same pains, also palpitation, as yesterday. 9th, 8:30 a.m., 1 teaspoonful. Shooting in right toes; pressure in both wrists. Boring in various places of head, in r. cheek, right knee right temple, on a little spot of outer side of r. calf. All these pains were repeated. Several n. cramp in the calves. 4 p.m., 1 teaspoonful. Besides the other pains marked boring in frontal prominences, on upper orbital edge, especially l.; also again at 10 p.m. At 6 p.m., whilst walking, violent pain in muscles on l. side under arm, along under part of chest to lumbar muscles, increased by each breath, lasting 5 m., and being increased by walking. Boring in the lower inner l. orbital edge, 11 p.m., repeated in the course of the day 8:30 a.m., 1 tablespoonful, and 9 a.m., 1 teaspoonful, which completed the ounce. The same pains as yesterday, especially the boring in the lower inner orbital edge of both sides; subsequently below and behind l. inner ankle whilst walking, in various parts of the frontal bone, the pains equally frequent whether walking or sitting. A strong cold wind which lasted several days brought on no increase of the pains. About 2 p.m. much tickling in the larynx without cough. In n. of 11th many dreams. On the m. of 11th palpitation on slight movement, the former pains being repeated. Pricking in rectum. 12th. -Same pains. Shooting several times in rectum and l. eyeball. On following d. urine much more scanty and dark. There appeared, now and then, pains up till 27th in limbs and head, especially boring in the forehead and side of the head.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.