DRUG SENSITIZATION AND DESENSITIZATION REPORT OF MORE CASES


Among chronic diseases we must still, alas! reckon those so commonly met with, artificially produced in allopathic treatment by the prolonged use of violent heroic medicines in large and increasing doses, by the abuse of calomel, corrosive sublimate, mercurial ointment, nitrate of silver, iodine and its ointments, opium, valerian, cinchona bark and quinine, foxglove, prussic acid sulphur and sulphuric acid, perennial purgative, etc.


This is a companion paper to the one presented before the A.I.H. meeting held at Atlantic City this week. The subject is so large that it is impossible to do it justice in a single contribution.

Hahnemann was the first to realize the importance of drug diseases. Quoting from Sections 74 and 75 of the 6th edition of the Organon:.

Among chronic diseases we must still, alas! reckon those so commonly met with, artificially produced in allopathic treatment by the prolonged use of violent heroic medicines in large and increasing doses, by the abuse of calomel, corrosive sublimate, mercurial ointment, nitrate of silver, iodine and its ointments, opium, valerian, cinchona bark and quinine, foxglove, prussic acid sulphur and sulphuric acid, perennial purgative, etc.

These inroads on human health effected by the allopathic non- healing art (more particularly in recent times) are of all chronic diseases the most deplorable, the most incurable; and I regret to add that it is apparently impossible to discover or to hit upon any remedies for their cure when they have reached any considerable height.

Hahnemann did not mention every inappropriate drug that was prescribed during his time for we find him adding “etc.” after the word seton in Section 74. Had he taken the time to include all such drugs his list would still have been small as compared with that of today. Our Food and Drug Act, though well intended, has turned out to be a farce, witness the exposures recently published in the newspaper “P.M.”, Exposing the Patent Medicine Racket, the author of which is a layman, Albert Deutsch. It appears as though Hahnemann is to be vindicated by a layman.

Up until the publication of the Exposing the patent Medicine Racket, no one has done much to support Hahnemann in his condemnation of the administration of inappropriate drugs “in large and increasing doses.” Before the exposure of the patent medicine racket is over let us give the credit to the one who deserves it, Samuel Hahnemann.

Albert Deutsch did well, very well, to expose the fallacy of prescribing inappropriate drugs in excessive doses over prolonged periods of time which is responsible for chronic drug dyscrasias, concerning which Hahnemann says in Section 75 “of all chronic diseases the most deplorable, the most incurable, and I regret to add that it is apparently impossible to discover or to hit upon any remedies for their cure, etc”.

As a result of intensive research during the past seven or more years I have been able to prove that of all diseases none are so easy to cure as those produced by drugs. The administration of any drug in excessive doses will in time cause a drug dyscrasia, after which the patient so sensitized develops a group of symptoms (chronic provings) which remain with him for years, occasionally for a life time. In the case of opium poisoning the symptoms remain for at least 40 years as I have found in more than one case.

Furthermore, the symptoms apparently produced by the drug are not those of that drug alone but are blended with the symptoms of other inappropriate drugs plus those of the natural disease. I have found more cases of multiple drug poisoning than of single. May I go so far as to say that I have seen more individuals poisoned from twenty drugs than from five or less.

When we put together five or ten poisons in one human organism how is it possible to disentangle the symptoms and prescribe a single desensitizing dose and and hope to accomplish a cure. It is not possible.

Every specific sensitization must be taken care of, otherwise it is not possible to effect a complete cure.

If a patient has been sensitized to opium and phenobarbital and then desensitized to opium the sensitization to phenobarbital still remains and vice versa. No drug will desensitize an individual to any other than its own specific sensitinogen. The nearest we can approach the desired results is with the homoeopathic similimum if at all possible.

CONTINUING THE PRESENTATION OF CASE REPORTS OF DRUG SENSITIZATION AND DESENSITIZATION BEGUN IN THE A.I.H.PAPER.

ESTIVIN: It is claimed to be “a local remedy for the alleviation of hayfever.” Mind you! It is not claimed to be a cure. Quoting the advertisement, “A large number of palliative remedies have not proved prompt, reliable and lasting in effect.” This is an admission that the “palliatives” have their drawback. This must be admitted by all who have had experience with palliatives.

They all appear to improve the patient for a short while only to be followed by the secondary effect, that of aggravation leaving the patient worse off than he was before. If the palliative is repeated a larger dose is required than the previous one in order to obtain the same results. Besides, the improvement lasts for a shorter period. It is claimed that Estivin is a prepared solution of Rosa Gallica. The few cases in which we used it in the higher potencies the results were just as effectual in desensitizing the patient as in the case of other poisons.

RAGE WEED: A maiden lady 45 years of age came to us suffering from autumnal hay fever which began about the middle of August and lasted until the last week in September (at the time of the first frost). She reacted positively to the rag weed skin test, followed by permanent improvement.

Like so many cases of its kind the patient was hypersensitive to several other sensitinogens; however, there were leading symptoms on occasions which helped to direct us in the attack on each. For instance, this patient carried a latent brucellin infection.

If one were to seek the homoeopathic similimum to cover her case it would necessitate the finding of a prover who had the same combination of infections that she had, as follows:.

1. Attacks of pneumonia.

2. Heavy attacks of obstinate influenza.

3. Chronic brucellin infection.

4. Chronic streptococcic infection with acute exacerbations.

5. Chronic staphylococcic infections.

Besides sensitization to the following drugs:.

Alophen Cocaine Phenolax.

Aspirin Coffee Pluto water.

Anacin Coryza tablets Quinine.

Benzedrine Ephedrine Sodium bromide.

Bismuth cevitate Eskay-neuro phosphates Tea.

Bisodol Milk of magnesia Vicks nose drops.

Caroid & bile salts Mineral oil Camphor.

Cascara sagrada Natures remedy(N.R.) Quinital.

Castor oil Opium Valerian.

Chloral hydrate Paregoric Cannabis indica.

To cure a case of this kind is quite impossible, for how can one hope to find a single remedy to cover the case. At the time most of the provings of homoeopathic remedies were made the drug abuse had not reached anything like its present proportions. However, by watching the patients symptomatology it is possible to find leads that prompt us to pick a drug to which the patient has been sensitized and then desensitize him to it, following which there is improvement in that part of the patient clinical picture corresponding to that drug.

Next, with ones mind attentively on the case of second lead is found and followed up in the same manner resulting in improvement proportionate to and corresponding in character to those symptoms produced by this second sensitinogen and so on until all of the drugs that have been inappropriately prescribed in excessive doses have been duly treated.

After removing all of the drug symptoms there is usually but little left to treat of the natural disease. We then direct our attention to the infections which are not nearly so difficult to handle as appeared at first sight.

The autumnal hay fever referred to was cured by Ambrosia in high potency. By what principle was the cure effected? It attention to the infections which are not nearly so difficult to handle as appeared at first sight.

The autumnal hay fever referred to was cured by ambrosia in high potency. By what principle was the cure effected? It was cured by identical drug that produced it. I would call it isopathy.

COFFEE: Sensitization to coffee is one of the commonest. We have seen many such cases. The one about to be related is as striking as any. It is possible that it has been referred to before.

The history of the case is as rich as any we have seen. Incidentally a case is no richer than the time spent on the study of it.

This patient was brought to the office with intense pain in the back and down the thighs. He walked up and down the floor moaning. It was not necessary to work over the materia medica as diligently as usual for I thought of coffee the moment I saw him. I asked how much he had been drinking when I learned that he drank more than 7 cupfuls daily. He was given one dose of Coffee in the 5M. potency.

He was improved materially within an hour and went to sleep, the first he had in 72 hours. The case is cited also to show how this patients coffee abuse was hiding behind a dozen other drug sensitizations and as many other infections. No one could convince him that he was not entirely cured of everything that was wrong with him at the time. His cure was prompt and permanent. Was it effected homoeopathically or isopathically?.

DIGITALIS, PHENOBARBITAL, ASPIRING COCAINE AND OPIATES COMBINED:

The case is that of a married woman 45 years of age who was severely poisoned with many vicious heart drugs including digitalis in material size doses over a prolonged period. Opiates in excessive doses had been used to ease her discomfort about the heart. The behavior of her heart was erratic. For a while it was very rapid then slow, next it would skip beats followed by extra systoles. Her pulse was most difficult to count. She complained of her heart “fluttering”.

“Photofluorograph of chest revealed great heart enlargement”.

(Signed)-Frank W. Burge, M.D. 3-16-44.

This patient was systematically desensitized to the following: Digitalis, Natrum mur., Strepto., Colon bacillus, Pluto water, Opium, T.B., Phenobarbital, Carters little liver pills, Codeine, Tobacco, Bromo Selzer and Alophen.

Treatment was begun March 7, 1944. On March 16 she said she felt very well, but still conscious of heart fluttering. On March 30, 1944, the patient stated that she felt all right in spite of irregularity of pulse; however, much less so than when first seen. She continued to report improvement on April 3, 6 and 10. Treatment was not discontinued so long as the patient reported increased improvement. Her case was remarkable from the viewpoint of those at the office and at her home.

She was not treated according to any pathologic diagnosis. That had been done before she came to us and proved a failure. She was not treated homoeopathically but isopathically with many sensitinogens, (according to the list of drugs furnished by the patient and her sister). The largest list of drug sensitizations thus far found:.

Alka Seltzer

Alumin

Aloes

Alophen

Alvesen

Aminophylline

Anacin

Analgesic slave

Cherocol

Chloral hydrate

Chlorotone

Cinnamon

Citrocarbonate

Coca-Cola

Cocaine

Cocoa

Codeine

Coffee

Cough drops

Carbon tetrachloride.

Conaylac seeds.

Coryza tablets.

Delvinal.

Digitalis.

Doanes kidney pills.

Doca.

Empirin.

Eno salts.

Ephedrine.

Ephedrine and amytol.

Epinephrin.

Ergot.

Eserine.

Eskay neurophosphate.

Estivin.

Estrogen.

Ex-lax.

Face powder.

Father Johns tonic.

Fel Sol.

Feosol.

Formaldehyde.

Ginger ale.

Gluco Phed.

Glyco thymoline.

Granya seeds.

Grove;s cold tablets.

Hair (cat, dog, cow, goat, horse).

Hair dye (inecto).

Asafoetida

Aspirin

Asthmodore

Benzedrine

Benzoin

Bismuth

Bisodol

Bromide of sodium

Heroin

Insulin

Isohalent

Ivory soap

Lextron

Lint

Lithia

Liver extract

Luminol

Mazon

Metaphed

Midol

Milk of Magnesia

Mineral Oil

Mistol

Molle Shaving Cream

Natures Remedy

Nembutal

Neoprontosil

Neo Synph.

Neuro phosphates

Neurosine

Novalene

Novatrophin

Nutmeg

Onion

Olive pills

Opium

Paint

Painodyne

Papes Cold Comp.

Paradine and sulphathiazole

Paragoric

Peony

Peppermint

Petroleum

Phenobarbital

Phenolax

Phenol

Pinoleum

Pluto water

Progesterone.

Bromo Seltzer

Camphor

Carters Liver Pills

Caroid and Bile

Cascara

Castor oil

Cedar wood

Cepacol

Propadrin

Prostigmin

Pussy willow

Quinace (acetanilid)

Quinidine

Quinine

Rabellon

Rem

Resinol soap

Red Top Snuff

Ruex shampoo tint

Sal Hepatica

Salicon

Salvitea

Sod. Salicylate

Sod. bromide

Silus aqueous nose drops

Serutan

Seconal

Sulfadiazine

Sulfanilamide

Sulfapyridin

Sulphathiazole

Talcum powder

Tea

Thiolar

Thyroid

Theobromine

Tobacco

Trexcene

Tums

Vercolate

Vicks nose drops

Vicks salve

Vitamins

Wheat flour (rye, graham)

Whisky

Wood alcohol

Yellow lax

Zilatone

Zonite.

The next case is odd in that I have never seen one just like it before. He is 59 years of age, tall and erect. He suffered for 20 years with a loose and productive cough and recurring attacks of intermittent fever.

Nasal breathing was obstructed on account of mechanical faults in the nose, however the nasal obstruction was added to by vasomotor paresis which in turn was due to the local treatment that were given him prior to his visit to me.

His history revealed that he was taking 48 different palliatives and some of these were compounded. I hesitate to take up the time to list them all. Alphabetically from A to G they are:.

1. Anacin.

2. Aspirin.

3. Asafoetida.

4. Bromo Seltzer.

5. Bicarbonate of soda.

6. Carters little liver pills.

7. Castor oil.

8. Cascara.

9. Cinnamon

10. Codeine

11. Cocaine

12. Empirin

13. Eskays neurophosphates

14. Ex-lax

15. Formaldehyde

16. Garlic & parsley

17. Glyco Thymol

18. Menthol cough drops.

To try to desensitize a patient to 48 drugs one at a time would require at least that number of visits, so I decided to give the patient at least 3 at a time, choosing, as carefully as possible those to which he appeared to be most sensitive.

The first day (Feb. 16, 1944) he was given by intracutaneous test: Codeine, Tobacco, and T.B. On the day following he was given Alcohol, Tobacco and Quinine, all in high potencies. His heaviest reaction the day following was to alcohol. It was 4 m.m. in diameter, red and underrated.

On Feb. 26 he was given Coffee, Sodium bromide and Natrum mur. By March 4th the patients cough was appreciably improved, however he continued to cough a little.

March 6th he reported that he slept well the past two nights, something he had not done for a long while. He had no cough during the night.

Photofluorograph of the chest revealed “bilateral flattened diaphragm.” (Signed)-F.W. Burge, M.D. Feb. 16, 1944.

At this writing the records go to April 27, 1944. The complete report of this case would be more voluminous than the one reported entitled Just One Case.

In both cases the patient made excellent progress as the result of nothing else than bacterial and drug desensitization. I fail to see how any other kind of treatment could possibly have succeeded.

PAPESS COLD COMPOUND: (Acetanilid, Ext. Belladonna, Powdered Aconite root, Phenolphthalein, Gum Turpentine).

It is rarely possible to find a patient who has been sensitized to a single drug. As a rule the patient first takes a drug, usually one that is not indicated and when it fails, as fail it must, he tries another and when that fails still another until it is found that he is eventually sensitized to many. The longer his ailment continues the greater the number of different drug sensitizations and the more difficult becomes the problem of restoring health, which is not possible until all of the drug sensitizations have been discovered and appropriately treated with desensitizing doses of the same sensitinogens.

No sensitinogen except the specific one that brought about the sensitization can possibly succeed in effecting a cure any more than an attack of typhoid fever will act as a prophylactic against whooping cough or any other dissimilar disease. Arsenic in sufficiently small dose can act curatively in a case of severe arsenical poisoning as I have observed more than once, but belladonna or any other dissimilar drug cannot.

TYPHOID FEVER SENSITIZATION: An interesting case of which is that of a City Hall detective, at one time a fine physical specimen. For a while before we saw him he was considerably broken in health mostly from drugs, so much so that his case could be divided up into many; however I shall restrict myself to the discussion of a single phase-typhoid fever sensitization and desensitization. As a recruit of World War I he was given the usual three injections of typhoid fever vaccine. He claims to have been made very sick.

He recovered sufficiently as to make a very creditable soldier, having been wounded a number of times and received as many decorations including the Purple Heart. Having made a number of studies of immunity and sensitization following attacks of the natural disease I decided to make a skin test with typhoid vaccine in the 4M. potency. The following day he presented a very large skin reaction, the largest I have ever seen. The negative phase lasted a few days after which he developed the positive with marked improvement. I had observed the same effects in a few other cases but in other infections notably.

I have made similar experiments in other infections notably pneumonia which have already been reported. However, the pneumonia sensitization was not made by vaccines as in the typhoid case. Could the improvement in the typhoid fever sensitization have been effected by any other than the isopathic remedy?.

MAGNESIUM SULPHATE: The next case is one of Mag. sulph. sensitization. Like the previous case Mag. sulph. was not the only drug to which the patient had become sensitized. On the other hand it is the one that stood out most prominently. All told he was sensitized to 20 drugs among which were included Anacin, Aspirin, Benzedrine, Bromo Seltzer, Cascara sagrada, Coffee, Ephedrine, Feosol, Natures remedy, Histamin, Mineral oil, Phenobarbital, Tobacco, Lugols solution of Iodine, Vicks Nose drops, Vicks salve, Seventy per cent of these drugs are capable of producing the symptoms for which the patient sought relief-Menieres syndrome.

In spite of the many poisonous drugs taken by the patient the one that did the most damage as prove by the diagnostic and therapeutic tests was Mag. sulph. The cure was effected by the same sensitinogen in high potency (isopathically).

VICKS NOSE DROPS: A middle aged female, a Salvation Army officer, had used Vicks nose drops over a prolonged period until she became severely sensitized. She suffered mostly from an irritating discharge from the nose both anteriorly and posteriorly. Almost any kind of nose drops or spray containing a petroleum base is capable of doing the same thing. Her history was lengthy but in part is irrelevant for which reason the report is made as briefly as possible, merely for the purposes of bringing out the fact that Vicks can produce the very thing it is intended to cure. Further more, its mere discontinuance is beneficial but not so much so when combined with specific desensitization treatment. In this as in other cases of its kind the results were prompt and better than is possible by any other form of treatment.

CASCARA: The Cascara-Senna group produce skin eruptions quite similar to Phenolphthalein (Di-Hydroxyphthalophenone) consisting of a dermatitis covering the entire body, some cases bullous in form.

Many of the patent medicines are claimed to be non-poisonous because some animals tested do not succumb, for instance, Goodman & Gillmans work on Pharmacology, published by MacMillan Company as recently as 1941, in speaking of Phenolphthalein, page 803, claim it was impossible to poison animals with the drug. It is impossible to judge of the toxicity of a drug on humans by animal experiments.

Again, the innocent appearing drug may produce no pathologic effect. However the same continued over a prolonged period and in increasing doses will sooner or later produce profound effects just as a very small dose of Sodium chloride, frequently repeated, will in the course of time produce pathogenic effect for which Nat. mur. works beneficially in the CM. potency.

BROMO SELZER AND ASPIRIN SENSITIZATION: The patient I am thinking of in this connection is a man 42 years of age, was referred by Dr. E.H., a graduate of an old school college. The condition for which he was referred was vertigo which dates back 4 years. There was associated with it dullness of hearing and buzzing noises in the left ear. This triad of symptoms, hearing loss, tinnitus aurium, and vertigo constitute Menieres syndrome often misnamed Menieres disease.

The patient gives the history of having had gall bladder trouble, severe pains in the head accentuated in the occiput. I made a preliminary examination on April 21, 1944, on a day when Dr. H. could be present. By arrangement the three of us, the patient, Dr. H. and myself, met at my office on April 28, 1944, when the patient reported he felt the same as on the previous visit. Functional hearing tests were made. The hearing was found to be quite shy on the left side, normal on right. Pulse 57, regular, temperature 98.4. There was spontaneous nystagmus to the right when looking to the right; to the left when looking to the left; more pronounced to the left side when looking to the left than to the right side when looking to the right. He was given intracutaneous tests with Bromo Selzer and Aspirin.

I met Dr. H., who referred the patient, on May 7, when he reported that the patients condition had entirely cleared up. I suggested bringing the patient in again, and he replied the patient was so satisfied with his present condition he saw no need for reporting again.

As to which of the two drugs did the more good it is doubtful but it looks as though it was the Bromo Selzer, for the skin reaction to the Bromo Selzer was definitely more pronounced. May I ask anyone interested, would they consider this improvement due to the action of the homoeopathic or isopathic principle?.

George W. Mackenzie