EXPERIMENT (PROVING) OF HISTAMINE HYDROCHLORIDE ON HUMANS



Dryness of nasal cavities with sensation of their being widely open. Pricking in nose, sneezings. Drawing of periorbital and perioral muscles. Painful tension at root of nose and pricking at inner angle of eye. Ears obstructed. Stitches in ears. Precordial oppression, propagating to left upper limb. Sensation of having inserted something into the heart with stitches at left nipple and sensation of lack of air.

Modalities: Better by pressure, by cold.

STOMACH HUNGER AND THIRST

Nausea with sensation of distress and bitter regurgitations in mouth.

Nausea when thinking upon eating.

Food causing nausea.

Nausea with sensation of fullness.

Belching with taste of eggs.

Strong and noisy belchings.

Gases compelling to get up for belching.

Emptiness at stomach, with tiredness in legs, desiring to sit down or lay down.

Heaviness in stomach, as if it was about to burst.

Painful heaviness at epigastrium.

Burning and pyrosis in stomach.

Burning in stomach half an hour after breakfast.

Burning after some meals, as if stomach was afire, lasting for some hours.

Pain at epigastrium and afterwards in girdle, stabbing, obliging, when sitting to sway back and forwards.

Pain in stomach with feeling of general distress, nausea and heat in face and head.

Pain as produced by gases.

Pain like after eating indigestible food.

Burning pain in epigastrium with loss of appetite and nausea.

“Nervousness” at epigastrium, with sensation of knotting or tension when receiving any news or remembering some disagreeable happenings.

Appetite diminished.

Concomitants: Hydroaerial noises in abdomen. Colicky abdominal pain. Pain in vesicular region. Pain in hepatic region with burning. Stools less coloured. Feelings of general distress, with weakness and dizziness. Chills, feverish sensation. Heat in face at the same time feeling cold in body. Tension in head. Burning and dryness of throat and rino – pharynx. State of giddiness.

Dullness of head. Burning occipital headache. Sensation of partial numbness in various parts. Otalgia. Neuralgic maxillary pain. Sensation of loose teeth. Sensation of something being inserted in region of heart. Sensation of lack of air and discomfort at left nipple.

ABDOMEN

Belly hurting and distended.

Distress in hypogastrium.

Burning like fire in belly, propagating in girdle.

Tensive pain, in girdle, as if something was compressing around abdomen and waist.

Pain in right hypochondrium extending to lumbar region and left lower limb; to the back.

Pain in right hypochondrium, stitching, dull.

Pain in cistic region, as if continuously being pressed upon by a finger.

Liver enlarged and sensitive to palpation.

Painful contractions in vesicular and epigastric region, followed by a diarrheic disposition, black as tar.

Tearing pains in lower abdomen.

Tearing pain on right side of lower belly.

Stitches in hypogastric region when sitting.

Concomitants: Nausea. Stools less coloured. Dark stools with some yellow and clear particles. Diarrhoea with colour of tar. Constipation. Rectal tenesmus. Oppression on chest. Difficulty to breathe. Cough Arthralgia. Dizziness. Pain in throat. Burning occipital headache. Compression at mastoid region. Stitches in ear. Pricking in various regions.

RECTUM AND STOOLS

Stools little coloured.

Black, fetid stools.

Diarrheic stools, black like tar.

Dark stools with some very clear particles of yellow colour.

Smooth, abundant, greenish stools, like paste.

Very dark or very clear stools.

Diarrhoea with great cutting pains in abdomen and generalised chills.

Diarrhoea, preceded by intestinal pains, as after a strong cathartic, with contractions from pelvic region towards rectum, and shiverings and perspiration.

Constipation with desires to evacuate.

Imperious necessity to defecate.

Rectal tenesmus.

Feeling of distress in abdomen with sensation of rectal tenesmus, as before onset of diarrhoea.

Tenesmus with expulsion of fetid gases and feeling of distress in abdomen with colics.

Constriction in rectum with persistant desires to evacuate.

Difficulty to expulse smooth stools.

After evacuating, sensation of not having evacuated the rectum totally.

Increase of intestinal gases.

Concomitants: Epigastralgia. Nausea. Pain in cistic region. General discomfort. Myalgiae. Oppression on chest with lack of air. Headache. Dry mouth. Dryness and burning in rhino – pharynx.

Dryness of conjunctivae.

URINARY TRACT

Cystitis.

Intolerable burning in bladder, micturition at every moment drop by drop, despairing and suicidal ideas, walking desperately up and down.

Micturition standing, drop by drop, at any place, with intensive urge, with protrusion of hemorrhoids.

Urines burning like fire.

Passes hours squatting and pushing.

Urine of normal aspect, chemical analysis being normal too.

Necessity to urinate, as if distended bowels were compressing bladder.

Stitches from bladder to urethra.

Stitches in urethra.

Sensation as from shot grains advancing towards ureteral meatus.

Painful drawing, as if something was contracting in left ureter.

Pain at left sacral region, propagating to posterior base of hemithorax of the same side, followed be imperious need to urinate.

Concomitants: Desires to vomit. Myalgiae and arthralgiae. Neuralgic maxillary pain. Ears obstructed. Itching in various part. Numbness in various parts. Numbness in various parts of limbs.

THORAX – RESPIRATION TRACT

Stitching pains in thorax.

Stitching pains, at height of 3rd, 4th, 5th costosternal joint; chest; upper third of sternum; in one or the other hemithorax.

Stitching pain in ribs of left side with sensation of heat.

Stitches in side with suffocation.

Stitch in thorax waking various times a night with strong pressure on neck.

Stitches in hemithorax followed by sensation of painful bruisedness.

Painful oppression on chest.

Oppression on right hemithorax and left intramarian region towards the back; in the middle of the chest; on one sternal region towards the right; in the middle and upper part of chest; in the middle of the chest and left mamarian region; in the middle and left part of chest; at the right nipple.

Oppression upon deep incomplete inspiration.

Painful continuous oppression, disappearing during inspiration, reappearing in the middle of expiration and increasing at the end of it.

Oppression with lack of air.

Oppression with lack of air, sensation of nasal mucosae being swollen, nervousness and restlessness.

Oppression as if an enormous weight was lying upon one side of the chest, with restlessness and desires to walk up and down without any purpose.

Constriction, with desires to breathe deeply.

Oppression at sternal region, with dry, short cough.

Contusive pains in left hemithorax, with oppression preventing from lying down on that side.

Bruised sensation on sternocostal chest – wall.

Contusive pain at posterior base of right hemithorax.

Subclavicular pain, on the left, increasing upon expiration and diminishing with inspiration.

Throbbing pain at the right side of sternum.

Burning pain on apex of sternum, towards its left side.

Pain with internal heat of left hemithorax, with dizziness.

In the memory of DR. ARMANDO. J. GROSSO, homoeopathic physician, who encouraged my first steps in this field of medicine.

I dedicate this paper to Mrs. Battista Elena, V., F.N.E. de, kniznik Nelly, Martinez Dora Z., Tempone Irene O., to Misses Alesia Ana, Bertora, Zulema, Nissen Helen, Pino Laura, Rietti Helena, Rosenthal Raquel, Zalutzky Dora, to the doctors Escalante Dardo, Gradia Wolf, Kriner Jose, Martines Carlos, Mesones Humberto, Moize Jonas, Moize Miguel, Munilla Julio B., Bedriguez Velo Angel, Rosenblum Dumoutier Andres, Roux Horacio L., Taratuto Raul, Wiurenos Dardo to the pharmacists Miss Di Santo Doelia and Messrs.

Hochstetter Felix, Hochstetter Kurt and Martinez Juan A., and to Messrs. Armaolea Avelino Feizo Alejandro, Godoy Nestor, Hochstetter Carlos, Kniznik Moises, Leibson Leonardo, Lopez Bernabe. Rodriguez Heriberto, Silva Garretson Euduardo, who cooperated as volunteers enabling us to carry out this proving. Their proving notebooks evidence a civil heroism that deserves the gratefulness of all those who now are in possession of another weapon to fight disease.

General Conditions of the proving.

The general conditions of the experimental method for a homoeopathic proving of histamine hydrochloride were complied with in the following way:

1. 39 volunteers of both sexes took part in the proving, without any signs or symptoms of disease at the moment or during the months preceding the proving. Exceptions: Prover No.1, who suffered from a so – called “allergic coryza”; prov. No.25, an asthmatic; prov. No. 32 with a rheumatic disease of the spine. The laboratory examinations of some provers also resulted in figures that might be considered as abnormal.

2. Provers were submitted to a general clinical check – up. The following laboratory examinations were made: Kahn standard and presumptive reaction, glycemia, blood – urea, red cell count, white corpuscles formula, Schillings hemogram, erythrosedimentation -rate, chemical and parasitological examination of stools, urine analysis, electrocardiogram, tele – radiography of thorax. Moreover a Rorschach psycodiagram was obtained from each of the provers, method which at present is considered the most adequate and less objectionable in order to discover the psychic structure of personality.

Jacob Gringauz