EXPERIMENT (PROVING) OF HISTAMINE HYDROCHLORIDE ON HUMANS


Difficulty to concentrate upon or to follow conversation. Bad humour, desires to be left alone. Superficial burning in various parts of face and lips. Nasal and buccal pricking. Tickling in various parts of face and lips. Numbness of lips. Muscles of face feel stiff. Fibrillar jerks visible in various muscles of face and periorbital muscles. Itching in various parts of body and in external auditive ducts.


Reprinted from Journal of the American Institute of Homoeopathy Jan. 1952

EARS AND AUDITION

Pain or discomfort in one or both ears, propagating to surrounding region; to neck; to lower jaw and temporal region; to forehead; to lower jaw, cheek and anterior region of ear; to neck and forehead; to upper maxillary; to submaxillary region; to occiput and superior part of neck; to part of superior part of neck; to maxillary and occipital region; to neck, maxillaries and occipital region of the same side; to inferior canine and one side of head; to jaw and neck of the same side.

Painful compression at base of ears, propagating frequently to neighbouring regions.

As if a foreign body would press base of ears one against the other.

As if head was compressed laterally at the ears and part of surrounding brain.

As if a finger was introduced in each ear pressing.

As if a base of ear was being compressed causing pain in neighbouring regions.

As if there was air at pressure in the base of ears.

As if the whole zone surrounding the ear was being compressed.

As if a bathing – cap was compressing the lateral part of the head at the height of the ears.

Pressure from inside outwards at both ears.

Painful compression at mastoid region, propagating sometimes to neighbouring regions.

Ears obstructed.

Both ears obstructed at the same time, or one of them, or alternating one and the other.

Obstruction and alternate clearing of ears.

Ears obstructed with sensation of compression at the base.

Sensation of fullness in ears.

Ears humming, like deaf for some moments.

Buzzings and whistlings.

Buzzings, and obstruction of ears previous to pressing pain from inside outwards at one side of head.

When swallowing saliva, ears are humming, with relief of the obstruction.

Pains, stitching, tearing, dull.

Contractions of particular muscles.

Drawing in external auditive duct.

Red and burning ear.

Pricking in ear like by chillblains.

Itching at entrance of external auditive duct; in both duct or only in one; or lobe of ear.

Concomitants: Superficial burning sensations on head and face. itching on lids and other parts of body. Heat in face. Picking at left frontoparietal region. Pricking at internal side of thigh. Burning in eyes. Stitches in eyes. Superciliar pain. Compression of the whole head. Sensation of dullness in head. Burning occipital headache. Heavy supraorbital headache. Odontalgia. As if a forceps was compressing root of nose from outside.

Sensation of nostrils being dry and wide open. Drawing at zygomatic region. Pain in throat. Dryness of throat and larynx. Myalgiae and arthralgiae. Partial numbness of limbs. Toes, swollen red and hot. Sensation of electricity running through the hand. Weariness.

Lack of strength and will. Tremor of hands. Dizziness. Pain in chest wall. Oppression and difficulty to breath. Cough. Precordial pains. Palpitations. Queer precordial sensation. Pains in hypogastrium. Pain in left testicle. Burning at stomach.

Modalities: Better by cold.

NOSE AND OLFACTION

Itching without eruption, fugitive, on the whole back or half of the nose; on one of the wings; on the tip of the nose.

Superficial burning at the back of the nose; on its tip.

Pricking at one half of back of the nose.

Sensations of drawing skin or as if skin was contracting at back of the nose; at one of its halves; at back of nose and right frontal region.

Visible and repeated contractions of skin at one side of nose.

Drawing at back of the nose.

Sensation of pinching at root of nose.

As if a forceps was put on root of nose, compressing it from the outside.

Painful tension at root of nose.

Contusive bruised pain at nose.

Sensation of bruised nose at one side of its halves, after blowing, hurting when pressed.

Contusive, bruised pain at whole back of nose; on one of its halves, at one side of root of nose.

Pain as from bone caries, “rotten bone,” at the base of cartilage and upper part of nasal wall at one side, increasing upon pressing on nasal wing of this side.

Pain when compressing wall of one nasal cavity.

Tensive pain at one half of back of nose.

DRYNESS OF NASAL CAVITIES

Sensation of nasal cavities being wide open with a nearly painful dryness being experienced in their interior.

Sensation of nasal cavities being completely open, without any secretion, with frontal headache and painful retro – ocular heaviness.

Dryness and burning of nasal cavities and reno – pharynx.

Dryness of nasal cavities with sensation of drawing at its root.

Dryness of nasal cavities, inspiration troublesome because of air inhaled being felt as cold.

Sneezing.

Discomfort at base of nose, reaching both ears.

Tickling, itching, pricking and picking in nasal cavities.

After sneezing, sensation of swelling of nasal mucosa and of a communication existing between nose and ears.

Sneezing with sensation of tickling.

Sneezing, no relief being obtained from them.

When sneezing, sensation of burning and dryness at nasal mucosa.

After sneezing nose obstructed.

Frequent sneezing upon inhalation of any kind of dust of surroundings.

Sneezings when handling leaves of sen or flowers of tile with sensation of burning. In nose and uncoloured, sticky secretion.

Series of sneezings.

Epistaxis during sleep.

Epistaxis when sneezing with sensation of heat in the nose.

Congested nasal cavity at its root or in one of its cavities.

Congestion at root of nose and eyes, as by insolation or cold.

Coryza with abundant nasal secretion and sneezings.

Coryza with burning, pricking sensation and nasal semi – obstruction.

Sensation of wet nose with scarce or no secretion at all.

Wet nose with nasal pricking and sneezings.

Wet nose, difficulty for entrance of air, afterwards nasal obstruction.

Wet nose, semi – obstructed, without secretion.

Gelatinous secretion like white of egg, sticky; watery secretion.

Yellowish secretions, green yellowish, white yellowish, uncoloured.

Green yellowish secretion of sour taste.

Smell as from humidity in one of the nasal cavities.

Concomitants: Superficial burning sensations in different parts of face. Compression of head. Head aching, heavy, hot. Pain in jaws. Numbness and tickling in different parts of face. Muscular jerks, visible at periorbital muscles and in face. Dryness of conjunctivae. Conjunctivitis. Heaviness of lids and tension in eyes. Buzzing in ears. Compression at mastoid region. Burning in mouth.

Itching in mouth and on tongue, Dryness of throat and larynx. Lacunar amigdalitis. Food tasteless. Myalgiae and arthralgiae. Pressing precordial pain. Tiredness and weariness. Chest hurting. Cough with tickling in throat. Epigastralgia and nausea. Abdominal pain with imperious desire to evacuate.

THROAT

Dryness of throat

Dryness of throat and larynx.

Red throat, dry and hurting.

Dryness especially on uvula.

Sensation of foreign body, ball or mass in throat.

Sensation of throat being opprested, as if a scarf was wound round it not permitting to swallow.

Aggravation by heat.

Pains, stitching, tearing dull, burning.

White dots on tonsils or crypts with reddening of tonsils, anterior tonsillar pillars and uvula. Pain and discomfort when swallowing dryly.

Concomitants: Anxiety. Nervousness. State of gay excitement with anxiety. Generalised prostration as during grippe. Dizziness with insecure walking. Tremor of hands. Burning occipital headache. Frontal headache. Pressive pain on mastoid region. Ears obstructed. Superciliar pain. Earache. Petro – ocular pain. Pain when moving eyes. Nose obstructed. Nasal dryness. Sneezings. Dry mouth. Thirst for cold drinks. Pain in testicle. Pain in muscles and joints. Difficulty to breathe. Cough with tickling in throat. Precordial oppression. Pain in lower abdomen.

Modalities: Better by cold, worse heat, swallowing.

MOUTH AND TEETH

Dry mouth.

Increase of salivation alternating with dry mouth.

Saliva of acid taste.

Picking, burning, pricking, itching sensations in the whole month; in mouth and on tongue; on one half of floor of mouth, under the tongue; at one half of tongue towards tip.

Stitches in floor of mouth.

Rough dots on tongue.

Tongue with thick white saburral.

Sticky mouth, with disagreeable taste.

Insipidy of food.

Vine tasting like perfume.

ODONTALGIA

Dull and drawing pains in all teeth; in superior or inferior teeth; in the teeth of one half of maxillary; in molars and pre – molars; in canines and incisives; in canine.

Pain in places from where teeth were already extracted.

Pain in certain regions of dental insertion, not well defined nor always in the same place.

Painful swelling of palate above molars.

Concomitance of symptoms in teeth with Precordial pains.

Sensation of loose teeth, avoiding to bite on them for fear of their breaking out and trying not to open mouth too much for fear of cold. Painful tickling in one tooth, such as caused by insufflation of air into a rotten tooth.

Concomitants: Superficial burning sensations in different parts of face. Pain and heaviness in head. Burning occipital headache, irradiating in an arch of heat to forehead. Burning occipital headache with simultaneous testicular pain. Neuralgic pain in one or the other maxillary, propagating to ear, sometimes. Numbness of cheek. Tickling in parts of the face. Itching in small zones of face and nose.

Dryness of nasal cavities with sensation of their being widely open. Pricking in nose, sneezings. Drawing of periorbital and perioral muscles. Painful tension at root of nose and pricking at inner angle of eye. Ears obstructed. Stitches in ears. Precordial oppression, propagating to left upper limb. Sensation of having inserted something into the heart with stitches at left nipple and sensation of lack of air.

Modalities: Better by pressure, by cold.

STOMACH HUNGER AND THIRST

Nausea with sensation of distress and bitter regurgitations in mouth.

Nausea when thinking upon eating.

Food causing nausea.

Nausea with sensation of fullness.

Belching with taste of eggs.

Strong and noisy belchings.

Gases compelling to get up for belching.

Emptiness at stomach, with tiredness in legs, desiring to sit down or lay down.

Heaviness in stomach, as if it was about to burst.

Painful heaviness at epigastrium.

Burning and pyrosis in stomach.

Burning in stomach half an hour after breakfast.

Burning after some meals, as if stomach was afire, lasting for some hours.

Pain at epigastrium and afterwards in girdle, stabbing, obliging, when sitting to sway back and forwards.

Pain in stomach with feeling of general distress, nausea and heat in face and head.

Pain as produced by gases.

Pain like after eating indigestible food.

Burning pain in epigastrium with loss of appetite and nausea.

“Nervousness” at epigastrium, with sensation of knotting or tension when receiving any news or remembering some disagreeable happenings.

Appetite diminished.

Concomitants: Hydroaerial noises in abdomen. Colicky abdominal pain. Pain in vesicular region. Pain in hepatic region with burning. Stools less coloured. Feelings of general distress, with weakness and dizziness. Chills, feverish sensation. Heat in face at the same time feeling cold in body. Tension in head. Burning and dryness of throat and rino – pharynx. State of giddiness.

Dullness of head. Burning occipital headache. Sensation of partial numbness in various parts. Otalgia. Neuralgic maxillary pain. Sensation of loose teeth. Sensation of something being inserted in region of heart. Sensation of lack of air and discomfort at left nipple.

ABDOMEN

Belly hurting and distended.

Distress in hypogastrium.

Burning like fire in belly, propagating in girdle.

Tensive pain, in girdle, as if something was compressing around abdomen and waist.

Pain in right hypochondrium extending to lumbar region and left lower limb; to the back.

Pain in right hypochondrium, stitching, dull.

Pain in cistic region, as if continuously being pressed upon by a finger.

Liver enlarged and sensitive to palpation.

Painful contractions in vesicular and epigastric region, followed by a diarrheic disposition, black as tar.

Tearing pains in lower abdomen.

Tearing pain on right side of lower belly.

Stitches in hypogastric region when sitting.

Concomitants: Nausea. Stools less coloured. Dark stools with some yellow and clear particles. Diarrhoea with colour of tar. Constipation. Rectal tenesmus. Oppression on chest. Difficulty to breathe. Cough Arthralgia. Dizziness. Pain in throat. Burning occipital headache. Compression at mastoid region. Stitches in ear. Pricking in various regions.

RECTUM AND STOOLS

Stools little coloured.

Black, fetid stools.

Diarrheic stools, black like tar.

Dark stools with some very clear particles of yellow colour.

Smooth, abundant, greenish stools, like paste.

Very dark or very clear stools.

Diarrhoea with great cutting pains in abdomen and generalised chills.

Diarrhoea, preceded by intestinal pains, as after a strong cathartic, with contractions from pelvic region towards rectum, and shiverings and perspiration.

Constipation with desires to evacuate.

Imperious necessity to defecate.

Rectal tenesmus.

Feeling of distress in abdomen with sensation of rectal tenesmus, as before onset of diarrhoea.

Tenesmus with expulsion of fetid gases and feeling of distress in abdomen with colics.

Constriction in rectum with persistant desires to evacuate.

Difficulty to expulse smooth stools.

After evacuating, sensation of not having evacuated the rectum totally.

Increase of intestinal gases.

Concomitants: Epigastralgia. Nausea. Pain in cistic region. General discomfort. Myalgiae. Oppression on chest with lack of air. Headache. Dry mouth. Dryness and burning in rhino – pharynx.

Dryness of conjunctivae.

URINARY TRACT

Cystitis.

Intolerable burning in bladder, micturition at every moment drop by drop, despairing and suicidal ideas, walking desperately up and down.

Micturition standing, drop by drop, at any place, with intensive urge, with protrusion of hemorrhoids.

Urines burning like fire.

Passes hours squatting and pushing.

Urine of normal aspect, chemical analysis being normal too.

Necessity to urinate, as if distended bowels were compressing bladder.

Stitches from bladder to urethra.

Stitches in urethra.

Sensation as from shot grains advancing towards ureteral meatus.

Painful drawing, as if something was contracting in left ureter.

Pain at left sacral region, propagating to posterior base of hemithorax of the same side, followed be imperious need to urinate.

Concomitants: Desires to vomit. Myalgiae and arthralgiae. Neuralgic maxillary pain. Ears obstructed. Itching in various part. Numbness in various parts. Numbness in various parts of limbs.

THORAX – RESPIRATION TRACT

Stitching pains in thorax.

Stitching pains, at height of 3rd, 4th, 5th costosternal joint; chest; upper third of sternum; in one or the other hemithorax.

Stitching pain in ribs of left side with sensation of heat.

Stitches in side with suffocation.

Stitch in thorax waking various times a night with strong pressure on neck.

Stitches in hemithorax followed by sensation of painful bruisedness.

Painful oppression on chest.

Oppression on right hemithorax and left intramarian region towards the back; in the middle of the chest; on one sternal region towards the right; in the middle and upper part of chest; in the middle of the chest and left mamarian region; in the middle and left part of chest; at the right nipple.

Oppression upon deep incomplete inspiration.

Painful continuous oppression, disappearing during inspiration, reappearing in the middle of expiration and increasing at the end of it.

Oppression with lack of air.

Oppression with lack of air, sensation of nasal mucosae being swollen, nervousness and restlessness.

Oppression as if an enormous weight was lying upon one side of the chest, with restlessness and desires to walk up and down without any purpose.

Constriction, with desires to breathe deeply.

Oppression at sternal region, with dry, short cough.

Contusive pains in left hemithorax, with oppression preventing from lying down on that side.

Bruised sensation on sternocostal chest – wall.

Contusive pain at posterior base of right hemithorax.

Subclavicular pain, on the left, increasing upon expiration and diminishing with inspiration.

Throbbing pain at the right side of sternum.

Burning pain on apex of sternum, towards its left side.

Pain with internal heat of left hemithorax, with dizziness.

In the memory of DR. ARMANDO. J. GROSSO, homoeopathic physician, who encouraged my first steps in this field of medicine.

I dedicate this paper to Mrs. Battista Elena, V., F.N.E. de, kniznik Nelly, Martinez Dora Z., Tempone Irene O., to Misses Alesia Ana, Bertora, Zulema, Nissen Helen, Pino Laura, Rietti Helena, Rosenthal Raquel, Zalutzky Dora, to the doctors Escalante Dardo, Gradia Wolf, Kriner Jose, Martines Carlos, Mesones Humberto, Moize Jonas, Moize Miguel, Munilla Julio B., Bedriguez Velo Angel, Rosenblum Dumoutier Andres, Roux Horacio L., Taratuto Raul, Wiurenos Dardo to the pharmacists Miss Di Santo Doelia and Messrs.

Hochstetter Felix, Hochstetter Kurt and Martinez Juan A., and to Messrs. Armaolea Avelino Feizo Alejandro, Godoy Nestor, Hochstetter Carlos, Kniznik Moises, Leibson Leonardo, Lopez Bernabe. Rodriguez Heriberto, Silva Garretson Euduardo, who cooperated as volunteers enabling us to carry out this proving. Their proving notebooks evidence a civil heroism that deserves the gratefulness of all those who now are in possession of another weapon to fight disease.

General Conditions of the proving.

The general conditions of the experimental method for a homoeopathic proving of histamine hydrochloride were complied with in the following way:

1. 39 volunteers of both sexes took part in the proving, without any signs or symptoms of disease at the moment or during the months preceding the proving. Exceptions: Prover No.1, who suffered from a so – called “allergic coryza”; prov. No.25, an asthmatic; prov. No. 32 with a rheumatic disease of the spine. The laboratory examinations of some provers also resulted in figures that might be considered as abnormal.

2. Provers were submitted to a general clinical check – up. The following laboratory examinations were made: Kahn standard and presumptive reaction, glycemia, blood – urea, red cell count, white corpuscles formula, Schillings hemogram, erythrosedimentation -rate, chemical and parasitological examination of stools, urine analysis, electrocardiogram, tele – radiography of thorax. Moreover a Rorschach psycodiagram was obtained from each of the provers, method which at present is considered the most adequate and less objectionable in order to discover the psychic structure of personality.

3. Usual subjective symptoms of the provers pervious to the experiment were registered by means of a special questionnaire.

4. Provers did not know each other. Exceptions: Provers Nos. 2 and 3, 9 and 10, husbands and wives respectively as well as the group of the Chillean provers: Nos. 34, 35, 36, 37 and 38.

5. Provers were informed separately about the general conditions of the proving, warning them about the fact that there would be test – provers, who were to receive papers, tablets or drops not containing any drug and without anybody knowing their identity aforehand.

6. Provers had no knowledge of the drug to be tried out Exceptions: No.2 (who prepared the drug) and prov. No. 39 (director of the experiment).

7. Provers had no knowledge of the dilutions that were to be tried out. Exception: No. 39.

8. Nos. 3, 22, 27, 28 were test provers; Nos. 22, 27 and 28 took the drug later on. None of them had any knowledge of their condition as test – provers; nor of the fact of being given the drug later on.

9. Each one received a note – book bearing the individual number of the prover. Each page was divided into two columns; the first one for the day and hour of the intake of the drug as well as for the day and hour of onset of symptoms. The second column adjoining to the first one, for the description of symptoms in case of their appearance.

10. Each note book carried a leaf with the following instructions: “Dont trust your memory. Write down every symptom in this note – book as soon as possible, each one on a separate line. Take note of day and hour, every time you take the drug. Describe what you feel without sing any technical terms and take note of hour of onset.

Try, being complete in description of your sensations, state localization, viz., write down the exact place of appearance; the kind of sensation, experimented, stating what you would compare the feelings to (for instance, if it was a stitching, throbbing, burning, tearing, sensation); modalities of sensations such as, (a) if it started suddenly or gradually, if it stopped gradually or suddenly, (b) hours at which the sensation experimented was felt most intensively; (c) influence of rest, movement or any other determined position such as standing, sitting or walking; (d) what effect is produced by being exposed to free air or closed premises; (e) What effect is produced by rubbing or pressing the part affected; (f) what sensations preceded, accompanied or followed upon the symptoms described.

Please make it clear in every case, if the improvement or aggravation experimented by any of the above circumstances might be considered as improvement or aggravation of local symptoms or of the organism as a whole. Describe way of sleeping, dreams occurring (write them down immediately upon waking). If there is any perspiration, describe where it appears, whether it is cold or hot, its odour, whether or not being irritant, if you feel better or worse after sweating or if it does not change your condition.

State your mood, whether there are feelings like anxiety, desires to weep, your reaction in front of company or loneliness, as well as every change in character. Moreover women will describe date of onset of menstruations, their duration, colour, aspect (whether fluid, coagulated or mixed), hours of most abundance, if there is an interruption for days or hours and anything that might call their attention in comparison with their previous menstruations and genitals.”

11. Provers reported news by telephone, one or various times a day. According to circumstances they were seen and examined by the director of the experiment every time it was considered necessary.

12. The rate of laboratory examinations was graduated in accordance with idiosyncrasy of every prover. The laboratorist ignored in all cases whether the results reported by him had any bearings upon the experiment.

13. In order to explore the susceptibility of the provers to the drug, proving was started with a 30th c. dilution. Those presenting symptoms upon 30th c., went on experimenting with 200th c., and 1000th c. and afterwards with 12th c., 6th c., and 3rd c., in the order mentioned. That means that every prover was trying a successive series of dynamizations. Exceptions: Provers Nos. 9, 23, 24, 28, 32, 39 who started directly at 200th c. Prov. No. 1 proved only the 30th c. and provers Nos. 24 and 39 only the 200th c. Provers not showing any symptoms with 30th c. continued provings with 12th c., 6th c., and 3rd c. (Till 30th c. inclusively, preparations were made according to Hahnemanns method: 200th c., and 1000th c., were prepared according to Korsakows method, but starting from Hahnemanns method : 30th c). In all cases the experiment started by taking only lactose not containing any drug. Exceptions: Nos. 10, 37, 39.

Jacob Gringauz