Within ten days the pains went into lower limbs and sore on labia had entirely healed, but patient complained of bursting sensations at crown of head as if from severe cold; occasional achings in teeth of left upper maxilla; pain in three toes of right foot, as if disjointed; nausea; thirst; feverishness. No medicine given. Three weeks later improved in every respect with only slight nausea remaining. Sub-maxillary ulcer had healed and there was marked improvement in general health. Syph.., one dose, given. The fistulous ulcer returned but yielded to subsequent treatment.