Clarke gives the toxic effects of homeopathy drug Spigelia and its therapeutic uses in non-toxic doses in his book The ABC Manual of Materia Medica and Therapeutics, published in 1901….



      The round-worm. Severe, intermittent supraorbital neuralgia. Shooting pains, swollen lids. Violent palpitation with pains shooting through the chest.


      Drowsiness, vertigo, flushing of the face. Lids swollen and stiff, dimness of sight, strabismus, violent pains in the forehead and eyes.1. Rapid and irregular pulse.2. General muscular trembling. Convulsions.


      Extractum spigeliae fluidum, 1/2-3 dr.

The large dose is used for vermicide purposes only, therapeutic effects being derived from the lower decimal dilutions of the drug.


      The round-worm. (Equal parts of the fluid extract and the fluid extract of senna. One to four drams every four hours).

Intermittent supra-orbital neuralgia. Pain is severe and may extend to the face.1.

Violent palpitation of the heart with pains shooting through the chest and down the left arm.2.

Rheumatic endo-and peri-carditis.2.

George Hardy Clark
Clark, George H. (George Hardy) 1860-1941 was the author of: Homeopathic Treatment of Asthenopia; Lee and Clark's Cough and expectoration : a repertorial index of their symptoms; The A B C Manual of Materia Medica and Therapeutics; A system for the care and training of children; The Black Plague and Its Control.