Clarke gives the toxic effects of homeopathy drug Hydrastis and its therapeutic uses in non-toxic doses in his book The ABC Manual of Materia Medica and Therapeutics, published in 1901….

      Golden Seal.


      Muscular debility with dilatation of the arterioles accompanied by an atonic and catarrhal state of the gastro- intestinal tract.

Chronic gastritis, especially of drunkards Stomatitis.

Uterine hemorrhages, cervical erosions.


      Paretic condition of all the voluntary and involuntary muscles with muscular trembling and tetanic convulsions pronounced dilatation of the arterioles. Paresis of the muscles of the heart. 1.


      Extractum hydrastis fluidum, 5-60 m.

Tinctura hydrastis, 5-60m.


      Relaxed and catarrhal state of the nasal mucous membranes. 1. (Internally and one part to fifty of water from atomizer).

Dyspepsia with lack of muscular tonus. (Five to fifteen drops of the tincture before meals)

Chronic gastritis, especially of drunkards. 1

Jaundice from catarrh of the gall ducts. 1

Constipation from a weakened and congested state of the lower bowel 1.

Stomatitis.1 (The fluid extract alone or in glycerin).

Uterine hemorrhage or menorrhagia due to capillary and muscular relaxation.1.

George Hardy Clark
Clark, George H. (George Hardy) 1860-1941 was the author of: Homeopathic Treatment of Asthenopia; Lee and Clark's Cough and expectoration : a repertorial index of their symptoms; The A B C Manual of Materia Medica and Therapeutics; A system for the care and training of children; The Black Plague and Its Control.