Clarke gives the toxic effects of homeopathy drug Helleborus and its therapeutic uses in non-toxic doses in his book The ABC Manual of Materia Medica and Therapeutics, published in 1901….

      Black Hellebore.


      Post-scarlatinal dropsy. Acute meningitis, stage of coma, the symptoms of effusion being well marked. Suppressed eruptions or dentition, with hydrocephaloid symptoms.


      The toxic effects appear to bear no relation to the therapeutic uses of this drug.


From the second decimal dilution to ten drops of the tincture.

The minute dose is preferred.


      Acute meningitis. Coma with exudation.

Dentition, with hydrocephaloid symptoms.

Effusions into the meningeal spaces consequent upon suppressed eruptions, etc.

Sudden dropsical swellings.

Anasarca following scarlet fever.

George Hardy Clark
Clark, George H. (George Hardy) 1860-1941 was the author of: Homeopathic Treatment of Asthenopia; Lee and Clark's Cough and expectoration : a repertorial index of their symptoms; The A B C Manual of Materia Medica and Therapeutics; A system for the care and training of children; The Black Plague and Its Control.