Clarke gives the toxic effects of homeopathy drug Cocculus Indicus and its therapeutic uses in non-toxic doses in his book The ABC Manual of Materia Medica and Therapeutics, published in 1901….



      Vertigo of cerebral origin. Carriage or train sickness.. Sick-headache, vertigo and colic at the menstrual period. Glosso labio-laryngeal paralysis. Weakness, tremor and spasms of the legs. Sweats.


      Vertigo of cerebral origin. Congestion of the brain. Contracted pupils, drowsiness, stupor.1. Gastro-intestinal irritation with nausea and loose evacuations.2. Respirations slow, labored, and shallow. Pulse slow.3. Loss of power in the lower limbs. Muscular trembling. General tonic spasm, followed by clonic convulsions, temporary paralysis and coma.4. Profuse sweating.5.


      Cocculus indicus, 1/2-3 m. of the saturated tincture. (Not officinal).

Picrotoxinum, 1/180-1/20 gr.


      Vertigo of cerebral origin.1. (Minute doses of the tincture).

Sea-sickness, carriage or train sickness with vertigo.1. (As for vertigo).

Sick-headache with vertigo at the menstrual period.1. (As for vertigo).

Tremors of chronic alcoholism.4.

Paralysis agitans.4.

Glosso-labio-laryngeal paralysis.4. (Picrotoxin hypodermically in doses of one-sixtieth of a grain).


Weakness tremors and spasms of the legs.4.

Convulsions of infants.4. (Minute doses of the tincture).

Epilepsy when not of long standing.4. (Begin with two drops of tincture twice per day. Increase one drop per day to fifteen drops, then reduce to original size of dose. Repeat after interval of fort night).

Flatulent distention.2.

Menstrual colic.4.

Night sweats.5. (Picrotoxin, one-hundred-and-eightieth to one-sixtieth grain hypodermically at night. Repeat when necessary).

George Hardy Clark
Clark, George H. (George Hardy) 1860-1941 was the author of: Homeopathic Treatment of Asthenopia; Lee and Clark's Cough and expectoration : a repertorial index of their symptoms; The A B C Manual of Materia Medica and Therapeutics; A system for the care and training of children; The Black Plague and Its Control.