The Carbon



Alteration of the colloidal state nowadays is made responsible for the process of hemolysis, and complement formation. According to Sachs complement activation is effected by an alteration of the state of the serum globulin, which need not exceed a certain step. Also according to him the complement effect in the presence of red blood cells will be released by a physical influence on the complement containing serum in the sense of a decreased dispersity of the globulin. Sachs ascribed to the physical state of the serum respectively its globulins, a very special significance for pathology and therapy. The complicated relations which exist on the introduction of colloidal silicic acid into the blood depend upon the already many times cited simultaneous action of the blood cells and the serum constituents. Sachs expresses this as follows;: “It is striking that non-specific substances (such a silicic acid) which are suitable for intermediating in complement action can also act anti-complementary. It simply amounts to the question whether the agents concerned are simultaneously mixed with blood cells and complement or whether the complement is mixed and then the blood added. In the first case the hemolysis appears and in the last case not, and indeed also when one has sought to intermediate through specific amboceptors. Likewise sodium silicate cannot convert a non-hemolytic system in to a hemolytic one. New pipettes which are used to measure a negative serum make this positive.

From all this we many conclude that the negative colloidal silicic acid can unfold a series of biologic actions on the body colloids and a very small amount but a very fine division is optimal for this. In these states of physical alteration silicic acid furthermore possesses some selective property, a certain grade of specificity which is dependent on the one side on the type of body colloid and on the other side by the dispersion and time sequence of the addition of the SiO2.

LEUCOCYTIC ACTIONS

Likewise a series a observations are available on the action of silicic acid on the white blood cells.

G. Zickgraf found generally an increase in the white blood cells after the oral administration of silicic acid. In the tuberculous the Glashager springs are said to improve the neutrophilic blood picture in the sense of a relative increase in the polynuclears. But the studies were not sufficient. From the tables the leucocyte increase in the mineral water patients is not evident in comparison with others.

S. Schwarz proceeds more exactly under the stimulation of the work arising from Kobert. At least he considers the definite variations in the number of leucoytes throughout the day. Through blood counts repeated 4 times a day t 2-hour intervals the number of white cells was determined systematically for 3 days. On the 4th 5th, and 6th, days the patients received 3/4 liter, in some case 1 1/2 liters Glashager spring water, that is, 40-80 mg. silicic acid while the blood counts on these days were continued in the same way. In other patient who received no or pure spring water control counts were made. From the records and graphic representations it may be concluded that in a vast majority the Glashager water cases showed a hyper-leucocytosis during the days the water was administered. Unfortunately no observations were made in respect to after effect. The increase amounted in three cases from 0 Percent of the original maximum in 10 cases up to 40 Percent in 10 cases 200 Percent of the original maximum. In some cases at first a slight hypoleucocytosis was observed exactly as has been demonstrated wtih nucleic acid by other investigators.

The increase of leucocytes by drinking Glashager water was also confirmed by Helwig in the healthy. In some cases a fall was also observed by him soon after beginning the ingestion, that is a hypoleucocytosis or a negative phase. Also an improvement in the sense of a nuclear maturation can be confirmed by Helwig on the basis of the blood pictures. Furthermore according to size, shape and coloring his blood pictures show that after the drink cure is begun there is a sudden new formation of small but very well differentiated leucoytes which gradually become replaced by normally colored and shaped active cells. Furthermore helwig tested the opsonic index of Wright and found after the administration of Glashager water in the healthy, a positive opsonic index of 2.4.

Helwig then studied the influence of silicic acid on the leucocytes and the opsonic index in a more detailed manner by animal experiment. As a preliminary investigation he determined the hemolytic dose of sodium silicate (Merck) in 1-2 mgl in 1 ccm. of a 0.9 Percent sodium chloride solution in 0.5 grams of defibrinated blood. The ingestion of bacteria in the leucocytes was studied by a simple method wherein apparently he did not separate the white cells form the red. Next the rectal injections of Glashager water or pure sodium silicate in rabbits showed a distinct special influence on the grade of phagocytosis. The bacterial ingestion was about 80-143.5 Percent higher than the normal. The total dose of silicic acid in Glashager water amounted to 3 mg twice in 24 hours. If the double dose, 6 mg. of sodium silicium was rectally injected then the special silicic acid influence increased from 80 to 143.5 Percent, On the other hand further increase of the dose evoked no increase but more a diminution of bacterial ingestion. Here also a distinct optimum is observed. When one thinks that it involves healthy rabbits, the dose in 48a hours, and particularly rectal injection, by which part of the grade of dispersity would be lost, then one can designate the dose as smell, since distinct effect differences are shown within the third decimal potency. Helwig himself remarks that smallest and small doses seem to act more markedly exciting o the ingestion by the leucocytes than do the next corresponding larger amount. The microscopic picture corresponds to the grade of phagocytosis in so far that in the lower grade the leucocytes and bacteria were scattered in high, leucocytes and bacteria were always more markedly clumped. Here too, one must think of the agglutinating action of silicic acid. Likewise the subcutaneous and intravenous injection of pure silicic acid solution gave a distinct optimum which lay within the 4the decimal potency. In doses withing the 3rd decimal potency the grade of phagocytosis was indeed distinctly lessened in comparison to the normal. The third decimal potency of sodium silicium indeed acted hemolytically in 0.5 ccm. of blood.

Furthermore Helwig studied 8 animals in which he had artifically suppressed phagocytosis with opsonogen, that is, with a vaccine made from dead staphylococcus culture. He also used the negative phase developing after such an imitated infection which was still distinct, according to his studies, 24 hours after subcutaneous injection. This negative phase is a well known phenomenon as the primary effect after infections and after some time will release increased phagocytosis. Now in this phase intravenously injected silicic acid solutions 18 hours before withdrawal cause a distinct increase of the opsonic index. And indeed this increase is proportional to the doses of silicic acid employed which varied from 0.00005-0.01 pro ccm. Whether this increase of action with increasing dose which far exceeded the hemolytic dose in other studies will be confirmed, is not determined as yet. But in no case does it mean that the same proportionality lies at the basis of therapeutic trials in actual infections. Because such a negative phase of infection never comes to treatment as it lies in the incubation period. In obvious disease the patient is in the positive phase also before increased phagocytosis and in order to stimulate this we need certainly not more but less than the amount necessary for the increase in phagocytosis in the normal animal. Much more we should be warned sufficiently through the existence of an optimum of action in order to summate the equally directed stimulus in the sick organism. But in any case one must select a dose smaller than the 4 decimal potency in order to expect a favorable result.

Finally Helwig made chemotactic studies. Thereby crok protected glass capillaries containing vaccines were introduced under the skin in accordance with Hamburger’s method. Also in these studies a distinctly more marked leucocytic infiltration occurred under silicic acid than without it. A relative leucocytosis and eosinophilia after administration of silicic acid has been reported many times.

Whatever significance one attaches to the leucocytic increase and the increase in degree of phagocytosis, it is clear that within certain limits they signify defense and protection for the organism and indeed exactly against the pus-producing bacteria. With this also stands that this defense can be supported through suitable silicic acid.

NON-SPECIFIC IRRITANT THERAPY

After the therapy of silicic acid was based first on a quantitative balance in SiO2 metabolism, later it was incorporated into non-specific irritant therapy. The appearance of fever and disturbance of general well being which one notices after parenteral introduction of being which one notices after parenteral introduction of being which one notices after parenteral introduction of colloidal silicic acid, for example, in the tuberculous who are capable of reacting with liable heat control and the hyperleucocytosis with neutrophilia are certainly non-specific irritant actions; but it is exactly the specific which interests us. For this reason nothing is gained for explanation when Zimmer also brings the oral administration of silicic acid under the general conception of non-specific irritant therapy. The production of general and focal reactions in rheumatic-arthritic processes is in general bound to parenteral administration, but it seems that it is obtained with certain organic silicic acid preparations orally. It is certain that the silici acid actions will be determined

Otto Leeser
Otto Leeser 1888 – 1964 MD, PHd was a German Jewish homeopath who had to leave Germany due to Nazi persecution during World War II, and he escaped to England via Holland.
Leeser, a Consultant Physician at the Stuttgart Homeopathic Hospital and a member of the German Central Society of Homeopathic Physicians, fled Germany in 1933 after being expelled by the German Medical Association. In England Otto Leeser joined the staff of the Royal London Homeopathic Hospital. He returned to Germany in the 1950s to run the Robert Bosch Homeopathic Hospital in Stuttgart, but died shortly after.
Otto Leeser wrote Textbook of Homeopathic Materia Medica, Leesers Lehrbuch der Homöopathie, Actionsand Medicinal use of Snake Venoms, Solanaceae, The Contribution of Homeopathy to the Development of Medicine, Homeopathy and chemotherapy, and many articles submitted to The British Homeopathic Journal,