445. Apoplexy not rare. [WEPFER, de Apoplexia, p. 24. (Not accessible.) – Mead l. c., p. 133. – VAN SWIETEN, l. c., p. 325. – LORRY, l. c.] (From large doses.)

Sinking of the powers. [CLARK,- WILLIS, l. c. §]

Debility, sinking of the powers. [REINEGGS, l. c.]

Unfit for all work, exhausted and weak. [CHARDIN, l. c.]

He can scarcely move the feet, can hardly walk forwards even when forcibly compelled to do so. [SCHELHAMMER, l. c.]

450. Exhaustion of the powers and inability to move. {FR. HOFFMANN, Dissert, de Operatione Opii, p. 8.]

He lay in the greatest weakness. [TRALLES, l. c., p. 238.]

The muscles move with greater difficulty. [BERGER, l. c., § 10.]

Increased immobility of the limbs. [SCHELHAMMER, l. c.]

The muscular tone is relaxed, so that a kind of paralysis ensues. [FRIEND, l. c., cap. 14.]

455. All the muscles relaxed. [LASSUS, l. c.]

Paralysis. [BAGLIO, (Statement.) Prax. Medorrhinum, lib. 1, p. 65. (From too many and too strong doses of opium.) ]

The limbs lay immovable, and remained lying in the place where they were laid. [KILIAN, l. c.]

Great prostration, sinking of all the vital spirits. [WILLIS, l. c.]

Discomfort, ill feeling of body and mind (aft. 8, 12 h.).

460. Syncope. [MULLER, l. c.- FR HOFFMANN, Diss de Correct. Opii, § 16.]

Syncope recurring every quarter of an hour; he closes the eyes, lets the head hang down, with weak respiration; without consciousness, with unaltered pulse; then some spasmodic shocks of the body, whereupon after a few minutes the paroxysm ends with a sigh; followed by anxiety. (The symptoms of Mullers’s patient before and after taking the opium were so similar, that the effects ascribed to the drug on his authority are very dubious.) [MULLER, l. c.]

Flow of blood from a recently opened vein (until death). [PET. BORELLI, cent. 4, obs. 57. (Observation.) ]

With increased powers she tries to get up out of bed, but immediately becomes faint and giddy; on lying down again she immediately revives. [MATTHAEI, l. c.]

Inclination to lie down. [GRIMM, l. c.]

465. yawning for several hours, with pain in the jaw-joints as if they would break. [Stf.]

Drowsiness. [BERGIUS,- MATTHAEI, l. c.]

Great inclination to sleep. [CHARVET, l. c.]

Sudden falling asleep (aft. a few m.). [CHARVET, l. c.]

Waking sopor.

470. Incomprehensible chattering in the sopor.

A kind of stupefied sleep, with half-opened eyes, eyeballs turned upwards under the upper lid, mouth more or less open and stertorous inspiration.

Drowsiness, slumber, stupefaction. [FRIEND, l. c., xiv, p. 140.]

Slumber. [SAUVAGES,- BUCHNER, l. c.]

In place of sound sleep it easily induces a morbid slumber. [TRALLES, l. c., p. 112.]

475. He lay as if sunk in slumber. [SCHELHAMMER, l. c.]

Nocturnal, continued sopor, with increased thirst, tongue almost clean, with dark red border and dry cracked lips. [JUNCKER and BOHMER,- MATTHAEI.;/ c/]

Soporous stupefaction. [DE LA CROIX, l. c.]

The sleep caused by opium passed into an unusual stupefaction. [RIEDLIN, l. c., ann. V, Oct., obs. 30.]

Such a stupefied slumber that an answer cannot be got from him. [STALPAART VAN DER WIEL, Cent. ii, obs. 42.]

480. Very sound sleep with rattling respiration, as after apoplexy (aft. 6 h.). [LASSUS, l. c.]

During almost constant slumber, with half-shut eyelids, he has floccilation and feels all about him. [RADEMACHER, l. c.]

Stupid sleep without any consciousness, with rattling on the chest. [KILIAN, l. c.]

Sleep with consciousness, with rattling on the chest. [KILIAN, l. c.]

Sleep with consciousness; he hears everything about him, but cannot rouse himself; waking after two hours. [CHARVET, l. c.]

On shaking the patient and speaking to her she can be roused from her sleep; she then complained and wished to die. [LEROUX.]

485. Sopor and insensibility, with sufficient warmth and normal pulse and respiration. [WILLIS, l. c.]

Unconquerable sleep, in which, however, he feels pain, and when pinched opens his eyes. [SAUVAGES, l. c.]

Irresistable sleep (immediately after taking two grains and upwards), but which is disturbed by dreams, and on waking he is not refreshed, but feels nausea. [A THUESSINK, l. c.]

Unrefreshing sleep with general perspiration. [GRIMM, l. c.]

After long opium sleep weariness. [YOUNG, l. c.]

490. On awaking faint-heartedness. (In original,”sense of faintness and failing about the heat, seizing him as often as he was dropping asleep.”) [YOUNG, l. c.]

After waking inclination to vomit. [YOUNG, l. c.]

After the opium sleep exhaustion, (Better “Lassitude.”) heaviness of the head, and dryness of the throat. [BERGIUS, l. c.]

During sleep erection of the penis, and after waking impotence – in the male. [STALPAART VAN DER WIEL., l. c., obs. 41.]

After the opium sleep stammering. [PLATER, Observ., lib. I, p. 127. (Not found.) ]

495. After waking difficulty of moving the tongue. (With the dryness of mouth of S. 158.) [SCHEHAMMER, l. c.]

After the sleep dulness of the head. [JORDENS, l. c., xvii, 1.]

Starting in sleep, and after waking he is as of intoxicated and half mad. [TRALLES, l. c., I, p. 282.]

After sleep intoxication and vertigo. [TRALLES, l. c., I, p. 282.]

More exhausted after waking, by uneasy dreams during the night. [TRALLES, l. c., I, p. 122.]

500. A man who had long been unused to dreams, dreams after taking opium. [RIEDLIN, l. c., ann. ii, Nov., obs. 16.]

The sleep from large doses of opium is not without dreams. [TRALLES, l. c., p. 120.]

The whole night occupied with a number of visions and fancies in sleep. [TRALLES, l. c., p. 121.]

The sleep of opium is always associated with dreams and grimaces. [LINDERSTOLPE, l. c., cap. 10, thes. 75.]

Merry dreams. [DE RUEF, l. c.]

505. Sometimes agreeable, sometimes sad, sometimes anxious and frightful dreams. [TRALLES, l. c., p. 120.]

Sleep disturbed sometimes by pleasant, sometimes anxious and frightful dreams. [TRALLES, l. c., p. 120.]

Sleep disturbed sometimes by pleasant, sometimes by horrible dreams, degenerating either into sopor or an apoplectic death with convulsions. [MURRAY, l. c.]

Opium affects the brain and produces uneasy dreams. [BELLONIUS, l. c.]

Deep sound sleep with rattling respiration, like an apoplectic. [LASSUS, l. c.]

Snoring. [DE LA CROIX, l. c.]

510. Snoring in sleep whilst expiring.

Whining in sleep (aft. 2 h.).

Piteous cry in sleep.

Restless sleep, full of sighs and moanings. [YOUNG, l. c.]

Anxious sleep, full of dreams (aft. 7 h.). [GRIMM, l. c.]

515. Anxious sleep disturbed by the saddest dreams, so that in slumberous intoxication he seems to be constantly delirious. [GRIMM, l. c.]

Sleep full of dreams.

Attack of suffocation in sleep (nightmare).

Sleep full of horrible phantasies and frightful dreams. [FR. HOFFMANN, Diss. de Operat. Opii, § 5.]

520. Sleep full of horrors; when he closes his eyes he feels as if he had lost his reason (aft. 3 h.). [SCHELHAMMER, l. c.]

Very vivid, vexatious dreams, in which everything goes wrong, there is much of an annoying and irritating character (aft. 2 h.).

Horrible dreams. [FR. HOFFMANN, l. c.]

Starting in sleep. [TRALLES, l. c., p. 282.]

Soft. Pleasant slumber, from which he is suddenly awakened by horrible jerks in the limbs. [Ct.]

525. Sleep interrupted by starting. [YOUNG, l. c.]

Restless, sleepless (Instead of “schlaflose” original has “traumlose” (dreamless), which, however, may mean the same thing.) night. [MATTHAEI, l. c.]

In spite of drowsiness he cannot go to sleep, with slow pulse. [GRIMM, l. c.]

The sleep-producing power of opium is much diminished by great pain or serious distress. [YOUNG, l. c.]

Sleepless night with restlessness and talking nonsense. [MATHAEI, l. c.]

530. Sleeplessness attended by unwelcome visions and full of phantasies, which are ver different from the things around him, as in insanity. [TRALLES, l. c., p. 122.]

Betwixt waking and sleeping dreams and visions of dragors, skeletons, and horrible ghosts and grinning spectres. [TRALLES, l. c., p.125.]

Restless night, sopor alternating with wakefulness, much raving hot skin and stupefaction, during which he lies in a heap. [MATTHAEI, l. c.]

Sleep and redness of face. [BERGIUS, l. c.]

From 108 the pulse falls to 72; at the same time chilliness and shivering, diminished activity, great exhaustion and yet increased hunger. [WARD, Neues Journ. d. Ausland. Medorrhinum Chir., lib. iv, 1.]

535. Diminishes the rapidity of the pulse and respiration. [A THUESSINK, l. c.]

Pulse first 14 beats slower (the first 4 h.), afterwards (aft. 10 h.) 30 beats quicker. [SAM. BARD, (Experiment on self with 1-1/2 grain doses.) Diss. de Viribus Opii, Edinb., 1765. (From rubbing in two drachms of opium – after 50 minutes.) ]

(Circulation diminished by one half. (This was seen by Alston (Edinb Vers., v., pt. I, sect, iii) through a magnifying glass in the foot of a frog, to which he had given some drops of tincture of opium.)

(The heart beats four times slower. [WHYTT, Neue Edinb. Vers., I, art. 19. (In a frog to which opium had been given.) ]

Large slow pulse, with laboured deep breathing. [DE LA CROIX, l. c.]

540. Large slow pulse, with slow, laboured stertorous breathing. [CRUMPE, l. c.]

Slow pulse.

Stronger pulse.

At first full, slow pulse, afterwards weak pulse. [BERGIUS, l. c.]

Slow pulse, with groaning, slow breath, very red, bloated face, and very profuse perspiration with convulsion. [MUZELL, l. c., p. 131. (From laudanum and hreatshorn.) ]

545. Full, regular, slow pulse, with deep stertorous breathing. [SAUVAGES, l. c.]

Weak, suppressed, slow small pulse. [FR. HOFFMANN, Medorrhinum Syst., ii, p. 537.]

He complains of chilliness. [WILLIS,- REINEGGS, l. c.]

Tendency to shiver. [REINEGGS, l. c.]

Diminution of the temperature.

550. Chilliness in the back, with suppressed, scarcely perceptible pulse. [SCHELHAMMER, l. c.]

Chilliness in the back.

Coldness of the limbs.

Thirst during the chill.

Fever; at first chilliness, then flying heat in the face (with white tongue, and perspiration before midnight).

555. Fever; first rigor, then heat with sleep, during which he perspires profusely.

(Fever; he falls asleep during the chill; no thirst during the chill; during the heat thirst and profuse general perspiration.)

In the evening in bed, immediately chill, and as soon as she falls asleep she breaks out in perspiration, which is particularly profuse on the head.

(Fever: Rigor with thirst, then increased heat of the whole body, with tendency to throw off the bedclothes, with strong full pulse, dryness of the fauces without thirst, and liveliness of the ideas and memory)(aft. 1 h.).

External coldness of the limbs. [WILLIS, l. c.]

560. Coldness with stupefaction. [CHARDIN, l. c.]

At first diminished temperature (shown by the thermometer), afterwards increased transpiration. [RONALDSON MARTIN, in vetensk. Acad. Handlung, 1773, pt. ii, No. 7.]

Strong, very quick pulse, which at last (aft. 8.1/2 h.). Becomes weak and inremittent (shortly before death). [ALSTON, (This symptom should read, “Her pulse, which was large, equal, and not very frequent, sank, and began to intermit a quarter of an hour before she died.”) Medical Essays. (From a scruple.) ]

Quick and uncommonly weak pulse, with quick, oppressed anxious respiration (aft. several h.). [GRIMM, l. c.]

Quick pulse with headache. [YOUNG, l. c.]

565. Quick, violent, hard pulse, with dark red face. [VICAT, Obs., l. c.]

Rush of blood to the brain. [HALLER, in Pralect, Boerhavii, iv, p. 509, – MURRAY, l. c.]

(The vessels of the brain were distented with blood, [MEAD, l. c.]

Violent, rapid, hard pulse, with difficult, obstructed respiration. [VICAT, Plantes Venen., l. c.]

Quickened circulation with sensation of heat. [MURRAY, l. c., pp. 281, 282.]

570. The blood-vessels distented. [MURRAY, l. c.]

Increased heat. [MURRAY,- YOUNG, l. c.]

Alternation of moderate heat with cold.


Great redness of face, with burning heat of the body, for eight hours; then convulsive striking out of right arm and leg, with loud cry, difficult breathing and coldness of face and hands, covered with heads of perspiration (shortly after taking it).

575. For six successive evenings, a burning heat in the face and feeling of heat especially in the eyes, without thirst. [Ctz.]

Heat with thirst. [CLARK, l. c.]

Increases the heat of the whole body and leaves dryness of the mouth and thirst. [BERGER, l. c., § 2.]

Sometimes dry, hot skin, sometimes slight perspiration. [YOUNG, l. c.]

Heat of the body with great anxiety. [BERGER, l. c.]

580. Intolerable heat with great anxiety. [MATTHAEI, l. c.]

Acute fever with delirium, which occurred after a short sleep and lasted twelve hours, after which he became very weak and sick, with weak pulse; after three hours, delirium returned which lasted forty eight hours, with strong full pulse; thereafter sleep for eight hours. [J. HUNTER, l. c., p. 641.]

With restlessness, oppression, confused ideas and sparks before the eyes, there rises up a burning disagreeable heat into the head which then spreads all over the body. [MATTHAEI, l. c.]

Perspiration (“Thick sweat” in original.) first on the head then all over the body, like drops of dew, and sleep. [MATTHAEI, l. c.]

Increased transpiration.

585. Perspiration only on bodily exertion.

General perspiration.

In the morning, during sleep, perspiration all over, with inclination to uncover himself (aft. 12, 36 h.).

Cold sweat on the forehead.

Perspiration only on bodily exertion.

General perspiration.

In the morning, during sleep, perspiration all over, with inclination to uncover himself (aft. 12, 36 h.).

Cold sweat on the forehead.

Perspiration especially on the upper parts, whilst the lower parts are hot and dry. [MATTHAEI, l. c.]

590. Almost always induces perspiration. [BERGER, BUCHNER, FRIEND, GEOFFROY, HALLER, PITCAIRNE, THOMPSON, WEDEL, l. c.]

Frequent perspiration. [MUZELL,- TRALLES, l. c., p. 134.]

Profuse perspiration (During convalescence.) (for 12 h.). [VICAT, Pl. Ven., l. c.]

General perspiration (aft. 6 h.). [GRIMM, l. c.]

During tolerably quiet sleep, profuse perspiration. [MATTHAEI, l. c.]

595. Perspiration very profuse, so that the skin itches and is covered by an eruption, whilst all the senses become blunted – touch, vision, and smell. [MURRAY, l. c.]

Perspiration and red miliary rash with itching, [TRALLES, l. c., p. 138.]

General perspiration of the extremely hot body, with great thirst, full, strong pulse, bright eyes and active mind. [MATTHAEI, l. c.]


Alternating state of careless sulleness and cheerfulness.

600. Taciturn reserve (after the smallest dose).

Tranquil indifference to earthly things; she cared for nothing in comparison with the ecstasies of the phantasy. [MEAD, l. c.]

Always quiet cheefulness of disposition; as if in heaven [HECQUET, l. c.]

Free from pain he remained the whole night in extreme cheerfulness of mind. (He had taken a grain in the evening for a very annoying pain.) [VAN SWIETEN, Comment., I, p. 878.]

The most agreeable sensation that can be imagined, with tranquility of mind and forgetfulness of all ills. [VAN SWIETEN, l. c.]

605. In no other way could she procure for herself complete tranquility and happiness of mind. [JONES, The Mysteries of Opium, revealed. (Observations.) ]

Not often an uncommon self-satisfaction and unusual tranquility of mind. [MOS. CHARAS, l. c.]

He did nosleep, but became as tranquil as if he were in heaven. [Eph.. nat. Cur., Dec. ii, ann. x, obs. 80. (After taking a moderate dose of opium for intolerable pain from stone.) ]

Sweet, delightful phantasies, which she prefers to all known happiness, chiefly when she had previously been tortured with pains. [BOEERHAVE, Praelect, in Inst., ad. § 856.]

Sensation as if he were in heaven, strong, delightful phantasies hover before him like waking dreams, which drive away sleep. [MEAD, l. c.]

610. The cheerfulness of mind from opium may rather be called a dream without sleep.[TRALLES, l. c., p. 122.]

Tranquility of mind. [DE RUEF, l. c.]

Activity of mind. [DE RUEF, l. c.]

A woman subject to melancholy thoughts is wonderfully relieved by it; her sorrow ceased for some time. (But, as it acted antipathically (palliatively), in order to procure the same relief, she must not only continue the use of opium, but increase the doses, so that at last she was obliged to take an ounce and a half of opium in one week.)

It causes the mental sufferings to be forgotten for a time and brings on an ecstasy and refreshing happiness of mind. [TRALLES, l. c., p. 98.]

615. It makes the (usually sad stupid) opium-eaters happy; they are very riotous, sing amorous songs, laugh much and play other pranks; this agreeable elevation of mind and disposition lasts an hour, then they became angry and uncontrollable, after which they again become sad and weep, until they go to sleep, and thus again return into their previous state. [ALPIN, l. c.]

Cheerfulness, liveliness, contentment, increased strength. [FRIEND, l. c., p. 139.]

Strength, liveliness, self-satisfaction. [Hufel. Journ., xiii, 1. (Not found.) ]

Invigoration. [MATTHAEI, l. c.]

Cheerfulness, inclination for work, fearlessness, courage. [ALPIN, l. c.]

620. Courage, intrepidity, magnanimity.

Feeling of courage and merriment, so that he is as if he would carry out what was required with energy, without repugnance or fear, with a peculiar feeling of voluptuousness (but lasting only a few minutes)(aft. ¼ h.).; immediately afterwards dulness in the head, &c. [Ctz.]

Intrepidity in danger. [REINEGGS, l. c.]

Opium inspires courage and resolution in one who is afraid of a surgical operation. [G. Young, l. c.]

Criminals (in India) lose their fear of death and go courageously to execution. [TRALLES, l. c. (The last nine symptoms are palliative primary actions of opium in otherwise melancholy timorous dispositions.) ]

625. Daring wildness. [REINEGGS, l. c.]

Wildness, cruelty like furious beasts. (In larger doses than those that give palliatively courage and increase strength to the timid and week, opium causes daring, unruliness, anger, and fury. This palliative primary action brings the Turks during the first onslaught in the commencement of a battle into an almost irresistable fighting fury, which, however, in an hour or two passes into the most cowardly irresolution or stupefaction, in which they are more easily conquered than any other army.) ]

Fury. [LORRY, in Recueil period., p. 74.]

Insanity and fury. [BERGER, De vi Opii rarefacient.]

Furious madness and distortion of the mouth (from applying opium on the temples). [LORRY, l. c.]

630. Confusion of the reason. [CLARK,- DE GARTER, Medorrhinum Dogm., cap. 1. (Not accessible.) ]

Delirium. [PITCAIRNE, Element. Medorrhinum, lib. ii, cap. 6, § 8.]

The patient has visions. [MULLER, in Hufel. Journ., xviii, 4.]

Fearfulness and fright. [YOUNG,- TRALLES, l. c.]

Want of courage.

635. Fear (aft. 8, 12 h.).

Horrible pictures of fancy. ]CLARK, l. c.]

She was troubled when awake with the supposed sight of ghosts, devils and spectres, (In original, “ghosts, spectres, and chimaeras.”) which she elieve to be surrounding her bed and which annoyed her much, as she chattered deliriously [TRALLES, l. c. (Every time her morbid states – palpitation of the heart, vomiting, hiccup, precordial pain, bellyache, trembling and convulsive movements – are relieved palliatively pain, bellyache, trembling, and convulsive movements – are relieved palliatively by opium.)

He chattered all sort of unconnected stuff and pointed with his fingers to imaginary masked people approaching him; sometimes he broke out into loud laughter; sometimes he started at imaginary swordsmen, who might kill him; he became angry when one talked to him and wished to regard him as insane, but in his delirium he accused himself of folly. [TRALLES, l. c., p. 126. (After opium given in a case of dysenteric diarrhoea.) ]

Delirious, he raves about all sorts of events, with open eyes, and afterwards remembers his chatter only as if he had dreamt it. [MANCHART, l. c.]

640. Hot, anxious and intoxicated she talked all sorts of things mixed up together, retracted what she has said, sometimes suddenly started sometimes angrily laid hold of the hands of those about her, [TRALLES, l. c., p. 125. (From opium given for indescribable pain that tended to pass into convulsions.) ]

He does nonsensical things. [REINEGGS, l. c.]

The increasing hilarity and happy thoughts pass into nonsensical and irrational behavious. [TRALLES, l. c. §]

Violent mania with red face, sparkling eyes and greater activity of body. [MATTHAEI, l. c.]

He throws himself about on the floor in am maniacal state, with burning anger and threatening expression, he does not know his friends; with swollen head and face, reddish blue, swollen lips, and projecting inflamed eyes. [TRALLES, l. c., p. 90.]

645. First ecstasy and thereafter sadness and dejection. [CHARDIN.]


Hopelessness, sulky disposition, moroseness (aft. 8, 12 h.).

Lamentable weeping and howling (in the first h.).

She is vexed about a pain so that she weeps.

650. Suspicion.

Fretfulness. [GRIMM.]

Melancholy. [BERGES, l. c.]

Anxiety. [RADEMACHER,- TRALLES, l. c.]

Horrible anxiety. [MUZELL, l. c.]

655. Praecordial anxiety and restlessness (aft. 2 h.). [YOUNG, l. c. (Ever renewed doses of opium were t only palliative relief for it, but only for a short time.)] raises a blister, erodes the skin and produces mortification. [BOERHAVE, De Morb. Nerv., .p 448.]

Eats into the skin, erodes the hair and causes itching. [JONES, l. c.]

660. eats into the skin, causes itching, erodes the skin and raises blisters. [GEOFFROY, l. c.]

Applied directly to the nerves, it does not take away their sensitiveness, but on the contrary increases the pain. [MONRO, Essays Phys. Amd Literar., vol. iii, p. 327 (Experiments on frogs. The author simply states that “when applied directly to a nerve, it does not diminish its functions.” (Name correctly given in 2nd edition, incorrectly as “Monno” in 3rd edition.)

Samuel Hahnemann
Samuel Hahnemann (1755-1843) was the founder of Homoeopathy. He is called the Father of Experimental Pharmacology because he was the first physician to prepare medicines in a specialized way; proving them on healthy human beings, to determine how the medicines acted to cure diseases.

Hahnemann's three major publications chart the development of homeopathy. In the Organon of Medicine, we see the fundamentals laid out. Materia Medica Pura records the exact symptoms of the remedy provings. In his book, The Chronic Diseases, Their Peculiar Nature and Their Homoeopathic Cure, he showed us how natural diseases become chronic in nature when suppressed by improper treatment.