General symptoms
Thyroidin. Thyroid Extract. A Sarcode. Trituration of the fresh thyroid gland of sheep or calf. Attention of a liquid extract of the gland.
Generalities
Malaise amel. by lying in bed.
Stooping = palpitation.
Rest in recumbent position amel. extreme breathlessness with lividity, felt as if dying.
Myxedematous patients are always chilly; the effect of the treatment is to make them less so.
Loss of consciousness and general tonic muscular spasm for a few seconds.
Fainting attacks (many cases).
Tremors, quivering of limbs, complete unconsciousness. (Tetany.) Epileptiform fit, after which he was unconscious for an hour; next day felt better and warmer.
Malaise so great refused to continue the treatment.
Agitation.
Incomplete paraplegia.
Hysterical attack. (Hysteroepilepsy with amenorrhea).
Nervous and hysterical, had to have nurse to watch her.
Feels tired and sick.
Stabbing pains.
Aching pains (many cases).
Aching pains all over.
Diffused pains.
Aching pains in various parts of body.
Pains over whole body.
Brawny swelling at point of injection, followed by abscess of slow development.
Myxedema removed (many cases). “A series of abscesses resulting from the injections, but probably originating from an accidental abscess quite independent of them.”
A small abscess formed.
Increased suppuration in case of lupus.
Gained a stone in weight.
Lost weight enormously (may cases of myxedema).
Rapid gain of flesh and strength.
Anemia and debility.
Infiltration rapidly absorbed (psoriasis).
Persons suffering from skin disease can bear much larger doses than those suffering from myxedema. (Acromegaly, headache, and subjective symptoms.) (Fractures refuse to unite).
A peculiar cachexia more dangerous than myxedema itself.
Syphilis, secondary, tertiary.
Mind
Acute stupor alternating with restless melancholia; at times could not be got to speak, but would lie on floor with limbs rigid; at other times would weep and undress herself; at times dangerous and homicidal, would put her arms round the necks of other patients so tightly as almost to strangle them (in this case the insanity was primary and the myxedema secondary; both conditions were removed). Evinced increased vivacity by quarreling with another patient about a trifling difference of opinion.
Depression.
Fretfulness and moroseness gave way to cheerfulness and animation. “All progressed cases of myxedema show some mental aberration which tends towards dementia, usually with delusions, the latter taking the form of suspicion and persecution. Occasionally actual insanity is present in the form of mania and insanity.”
Delirium of persecution (three cases observed, one fatal, the result of taking Thyr. in tables to reduce obesity).
Sudden acute mania occurring in myxedema, perfectly restored mentally and bodily under Thyr.
Mental aberration dating three years before onset of myxedema, subject to attacks of great violence, with intervals of depression and moroseness.
State of idiocy; fearful nightmares.
Excited condition, lasting all the rest of the day, grunting continuously and laughing in a way that was peculiar to herself.
Very excited; excited state followed by considerable depression.
For several hours in what can be only termed a hysterical condition.
Profound depression.
Irritable and ill-tempered.
Became a grumbler.
Angry.
Had frights.
Head
Vertigo.
Feeling of lightness in the brain, scarcely amounting to giddiness.
Much giddiness and headache for twenty-four hours.
Awoke about 4 A.M. with sharp headache and intense aching in back and limbs, which continued for three days and compelled him to keep his bed.
Ever since taking the first thyroid [had five glands altogether, at intervals.] he had a strange feeling in his head, with vertigo and palpitation on stooping.
Headache (with fever symptoms); disappeared on suspending treatment, reappeared seven days after recommencing.
Frontal-coronal headache after taking one tabloid for four successive days. (Constant headache, pains in occiput and vertex.) (Headache in case of acromegaly.) Headache.
Headache and pains in abdomen.
Fresh growth of hair (many cases).
Black hairs growing among the grey.
In one case of scleroderma and in one case of myxedema the hair fell of permanently.
In a case of myxedema the patient lost all the hair of his head and face and had a thick growth over his arms and thorax; under Thyr. The hair of the head and face grew again and that of the arms and chest fell off.
Eyes
(Prominence of eyeballs-exophthalmic goitre.) Optic neuritis (in five persons, four of them women, under treatment for obesity; no other symptoms of thyroidism).
Accommodative asthenopia.
Ears
Moist patches behind ears heal up (case of psoriasis).
Hyperplastic median otitis with sclerosis and loss of mobility of the ossicles (rapid amelioration – several cases.).
Face
Flushing: with nausea and lumbar pains; loss of consciousness, tonic muscular spasms; immediate; with rise of temperature, and pains all over; suddenly became breathless and livid.
Faintness, with great flushing of upper part of body and pains in back.
Swelling of face and legs.
In lupus of face, tight sensation, heat, and angry redness removed.
Burning sensation of lips with free desquamation.
Mouth
Tongue became thickly coated.
Feverish and thirsty.
Great thirst. (Ulcerated patch on buccal aspect on left cheek near angle of mouth.).
Throat
(Full sensation.) Goitre, exophthalmic, cured.
Goitre reduced.
Stomach
Loss of appetite.
Increased appetite with improved digestion.
Eructations.
Dyspeptic troubles.
Nausea, with flushing and lumbar pains.
Nausea, slight vomiting.
Slight nausea recurring on thinking of it.
Nausea soon after taking the gland.
On five occasions the patient (a woman) vomited the thyroid.
Always felt a sensation of sickness after the injections.
Sensation of faintness and nausea (after a few injections).
Feels tired and sick.
Gastrointestinal disturbance and diarrhoea.
Abdomen
Flatulence increased, followed later in the case by amelioration.
Headache and pain in abdomen.
Stool
Diarrhoea, with gastrointestinal disturbance.
Relief of constipation with more natural actions.
Constipation.
Urinary Organs
Increased flow of urine.
Increased urination, usually with clear, pale yellow secretion.
Slight trace of albumin found in urine.
Albuminuria.
Diabetes mellitus; caused and cured.
Female Genitalia
Increased sexual desire.
Six days after commencement of treatment menstruation, which has been absent over a year, reappeared and continued profusely (in several cases of myxedema with or without insanity).
Menses profuse, prolonged, more frequent; early amenorrhea. (Painful and irregular menstruation.) (Constant left ovarian pain, and great tenderness).
Looks pale and feels ill.
Pain in lower part of abdomen, headache and sickness (in girl of sixteen, probably menstrual effort provoked by Thyr.; no catamenial flow appeared).
Acts as a galactagogue when milk is deficient; when a deficiency is associated with a return of the menses it will suppress the latter. (Puerperal insanity with fever). (Puerperal eclampsia).
Respiratory organs
Slight attack of hemoptysis, followed by cough and signs of phthisis at apex of left lung. (Voice became clear).
Dormant phthisis; lighted up the disease in five cases.
Back and Neck
Flushing, nausea, and lumbar pains, lasting a few minutes.
Stabbing pains in lumbar region.
Intense aching in back and limbs, which continued for three days.
Flushing of upper part of body and pains in back. (Backache.).
Upper limbs
After injection, to a great extent lost the use of her hands for two days; recurred later, lasting a few hours.
Felt queer and unable to raise her arms (after injection, another case).
Arms less stiff and painful (psoriasis).
Lower Limbs
Tingling sensation in legs.
Edema of legs appeared, and subsequently subsided and continued to reappear and subside for a month.
Pain in legs.
Incomplete paraplegia.
Swelling of face and legs.
Feet frequently peel in large flakes, leaving a tender surface.
Profuse flow of fluid from feet (in case of dropsy cured by Thyr.).
Quivering of limbs; tremors.
Intense aching in back and limbs, lasting three days.
Pains in arms and legs, with malaise.
Skin of hands and feet desquamated. (Acromegaly, subjective symptoms.).
Sleep
Continual tendency to sleep.
Awoke about 4 A.M. with sharp headache.
Fearful nightmares disappeared.
Insomnia.
Excited condition; could not sleep.
Fever
Flushing: with nausea; with loss of consciousness.
Always felt hot, and had a sensation of sickness after the injections.
Felt better and warmer.
Flushing of upper part of body and pains in back.
