(3) Tyramine. The tyramine is obtained by decarboxylation of the tyrosine in the course of hydrolysis or out of the putrefaction of albumin. It is also found in Ergot, in mistletoes and in the saliva of some cephalopodas (R. Hazard). It also forms in the intestine of man and of animals under the influence of microbian fermentations (B. Coli, B putrificus and some pyocyanics). The tyramine is an excitant of the sympathetic system. Its physiological action is compared with those of adrenaline and is opposite of histamine, which is related in its action to acetylcholine. Tyramine causes hyperthermia and the waking up of hibernating animals. It accelerates the metamorphosis of tadpole. Experimentally it causes arterial hypertension and later on arterio-sclerosis. Normally it is the liver which should oxydise it and disseminate it. Also in case of the troubles of the liver it may be persist in excess in the organism.
On the uterus the action of tyramine may be annihilated by the presence of histamine. Tyramine and histamine are antagonistics; the first one augments the elimination of the residues of the nitrogenised substances and cause the elevation of the arterial tension; the second one dose the opposite, diminishes the elimination and causes hypotension.
it is therefore, interesting to try homoeopathic doses of tyramine in the treatment of hypertension and of arteriosclerosis using in the research all the possible ways of introduction.
Bodies with guanidic nucleus: creatine creatinine, and agmatine.
Creatine and creatinine enter into the metabolism of proteids and glucosides, as well as in the phenomena of muscular contractions. The creatine augments the effect of hypocalcemia caused by insuline.
Arginine, guanadine augment the effects of adrenalin on the arterial pressure.
To the homoeopaths it would be necessary to base themselves on the recent works observing the physiological effects of the excess of these bodies of guanidic nucleus to use it afterwards in homoeopathic doses.
Similarly for the choline and acetylcholine, which are also some amino bases.
Minerals, metals and metalloids. Examples are numerous. It is necessary to collect them together by and by and it is a necessary work for the edification of a medicine really scientific, based on the principle of similitude. Here are some short examples:
It is accepted that potassium is necessary in weak doses for the contraction of the myocardia, while in strong doses it depresses it. This justifies the homoeopathic use of Kali carbonicum. It is known that Hydrocyanic acid excites in feeble doses the centre of bulbar respiration while it inhibits in strong doses. This justifies the use of homoeopathic doses in case of goitre or in Basedow’s disease.
It is accepted that the rarefied dose of Iodine are necessary for the prophlaxis and the treatment of goitre, whereas the hyperthyroidism is related to the excess of iodine. This explains that Iodium may be used in homoeopathic doses in cases of goitre or in Basedow’s disease.
On the other hand, Fremont for the water of Vichy Amblard for the water of Vittel, have shown that the effects of the hydromineral cure are inverse according to the doses used. P. Ferreyrolles had already shown that this phenomenon may be considered as general for all mineral waters.
RADIO ACTIVE SUBSTANCES. Recall for memory that the action of the X-ray and of radium is inhibiting and stimulant as regards cancer.
VEGETABLE SUBSTANCES Alkaloids: It is admitted that Aconite provokes formication, that it to say excitation of nerves, which it benumbs in strong dose. This is one of the applications of the law of Arndt Schulz and is confirmed by the homoeopathic use of Aconite and Aconitine in microdoses.
The Strychnine in homoeopathic doses is a remedy of great value of which the indications are limited that that of Ignatia and of Nux vomica. Similar is the case with Cocaine and Coca… Recently quinine, obtained out of quinine has proved in homoeopathic doses to be an excellent remedy for cardiac troubles of tachyarythmia by auricular fibrillation or of tachycardia by hyperthyroidia, troubles that may be caused by strong gross doses of the same product.
PHYSICAL AGENTS.
I will not speak anything on this chapter, but it has been proved by Dr. Mondian that the therapeutic use of electric currents may be used according to the law of similitude.
Even the massage, the reflexotherapy of all kinds may give us confirmation of the principle of similitude, if one takes into account at the same time the necessity to individualise and for each individual his velocity and his reactional capacity.
Bernoville was a major lecturer in homeopathy, and he was active in Liga Medicorum Homeopathica Internationalis, and a founder of the le Syndicat national des médecins homœopathes français in 1932, and a member of the French Society of Homeopathy, and the Society of Homeopathy in the Rhone.
Fortier-Bernoville wrote several books, including Une etude sur Phosphorus (1930), L'Homoeopathie en Medecine Infantile (1931), his best known Comment guerir par l'Homoeopathie (1929, 1937), and an interesting work on iridology, Introduction a l'etude de l'Iridologie (1932).
With Louis-Alcime Rousseau, he wrote several booklets, including Diseases of Respiratory and Digestive Systems of Children, Diabetes Mellitus, Chronic Rheumatism, treatment of hay fever (1929), The importance of chemistry and toxicology in the indications of Phosphorus (1931), and Homeopathic Medicine for Children (1931). He also wrote several short pamphlets, including What We Must Not Do in Homoeopathy, which discusses the logistics of drainage and how to avoid aggravations.
He was an opponent of Kentian homeopathy and a proponent of drainage and artificial phylectenular autotherapy as well.