Atropine and its salts, obtained from Belladonna, are prepared for used by trituration. Physiological Action similar to Belladonna. Allied Drugs.- Belladonna, Hyosc., Stramonium, Sulphur, (Secale c.). Antidote.- Morphine, Nicotine, each in part.
Appears dull and stupid. Convulsions; especially of limbs; beginning in neck and face. Clonic spasms of biceps flexor cubiti and of muscles of jaw, (<) by disturbing the patient. Clonic cramp in face and limbs (moves arms forwards in front of chest). Staggering, then falling, with convulsive movements of limbs, then pupils much dilated, heart beating rapidly, tongue curled to roof of mouth, lips, mouth and throat dry, convulsions about once in five minutes, glossopharyngeal not responsive to tickling. Twitching in head and arms, with vomiting, face red, then pale, pleasant delirium, head thrown from side to side, fingers closed, arms flexed, convulsions of upper limbs, looking as if deeply drunk, after three hours clonic spasms over whole body, passing into toxic ones, pupils dilated, no reaction, difficult deglutition, voice hoarse and thick, skin insensible, dry, bluish-white, no fever, pulse small, frequent, soft, irregular, intermittent, respiration accelerated, superficial.
Jerkings; especially in legs, arms and face, when attempting to drink the arm contracted suddenly and the water was spilled, and when walking one or both legs contracted, throwing one to the ground. Hands tremulous and eyes closed, but she became quiet and drowsy, then kicking and throwing her arms about, limbs weak, unable to stand, face flushed, then meddlesome and pleasant delirium, picked at her clothes, tried to get out of bed, imaged she was sewing, nursing and yawning, then unconsciousness and stupor, eyes closed, pupils dilated, muscular system relaxed, except trismus, deglutition almost impossible, respiration labored and like that of an intoxicated person lids closed, conjunctivae injected, eyes brilliant and staring, tongue, hard and soft palates glazed and parched. Face flushes, pulse full, strong, hard and bounding, respiration almost stertorous, somnolency, impairment of senses, when aroused and raised u he would look around wildly, and when addressed in a loud voice muttered incoherent words, tremor, weakness, especially of lower limbs, so that he was unable to stand, though there was considerable strength in his arms, involuntary micturition. Convulsive trembling of one or another muscle.
Startings in women; S. at any sudden noise; at night when nearly asleep, as if frightened (Bell, Sul.). Busy with his hands, pulling the bed-clothes about. Restlessness; in morning on rising, and unrefreshed; with agitation of body and mind; with sleeplessness; with haste, becoming a desire to fight. Impossible to keep him in bed and difficult to keep him from walking about. Sensitiveness; to wounds and objects at night, with symptoms akin to early stage of meningitis, in morning rapid pulse, furred tongue and hot, dry skin. General discomfort. Weakness; morning on rising; in morning, lay in a half-dreamy sleep and after dressing great desire to lie down again; in open air; during stool, with nervousness, general discomfort and sweat; and trembling all over. Faintness and need of fresh air. Anaemia.
Motion difficult, and when I raised my arms they fell as if made of lead. Heaviness, drowsiness or actual sleep, with tendency to dreamy delirium. Numb or crawling sensation, formication, down back, on arms and backs of hands. Torpor and paralytic trembling. Anaesthesia (Abs., Aconite, Bel., Secale c.); and water glides over skin without moistening it or producing sensation. Lost the power to estimate distances either by eye or touch, touching an object produces no sensation. Better sitting or standing than lying.
Clinical It has been used homoeopathically for neuralgias; supraorbital, (<) emotion; earache; neuralgia under the knee, (>) warm wraps, etc. It has sometimes been prescribed for the symptoms of Belladonna, especially in meningitis, spinal irritation.
Delirium, with restlessness; (<) at night, with agitation; with drowsiness; followed by or alternating with stupor. Meddlesome D. Frightful phantasies. Spectral illusions at night. Struggling to rise from red (Belladonna). Jumping out of bed and insisting on dressing himself. Resists being undressed, saying continually that he shall lose the train. Restless and unmanageable, refusing to answer, swallow or to be examined, and appeared profoundly intoxicated. Delirious and restless, talking constantly about his affairs. Talked almost unintelligible nonsense in morning on waking. Attempts to reason. Insisted that her blood did not circulate, and that her feet must be put into hot water or she would die. Answers imaginary questions. Talked and laughed wildly, but answered questions readily, fancying that they were at home and attempting to arrange furniture. Returned answers when addressed, whose beginning showed that he understood, but which passed into irrelevant, senseless talk. Incoherent quarreling. Delirium after a chill, resembling the subdelirium of certain typhoid fevers. Busied with subjects which at other times occupy his mind, politics and struggles consequent on his relations in life. On closing eyes after retiring, mind filed with strange ideas, rambling, incoherent speech, spectral illusions, with first of wild, uncontrollable laughter, the delirium lasting all night, fancied that I was afflicted with epilepsy and afraid others would discover my condition, nearly oblivious of all that transpired the latter part of the night, but know from bruises and pains from contact with a stove, chair or some solid body that it was passed in the wildest delirium.
Delirium, resembling delirium, tremens; incessant rambling, restlessness, grasping at imaginary objects and screaming from fright, terror was depicted on his face, and he clung to his nurse’s neck or he threw himself in different directions to escape the frightful objects (Stramonium), later the delusions were pleasurable, of playing with toys, drawing, eating etc. Pleasing illusions, meddling with everything, picking at and handling imaginary object, with muttering and smiling, or with loud chattering interrupted by subdued laughter. Hallucinations, grasping at imaginary objects, with staggering, rapid, full and strong pulse, drowsy, stupid, answered in an indistinct tone but rationally, afterwards, coma increased, head hung upon his shoulders in a limp state, unconscious, respiration ceased and artificial respiration was resorted to. Picking at specks and at the air, on lying in bed. Picking at bed-clothes, as if searching for something at night, with confused mutterings (Hyoscyamus). Incoherent quarreling. Frenzied with excitement. At times when it seemed to him as if he were fully conscious he saw persons at the bedside, and slowly reached out to grasp them, or saw books and newspapers which receded, or the hand would come in contact with them and feel nothing. Felt a wet cloth on my head, but supposed I had been out in the rain without a hat, etc., etc.
Delirious, but not wholly unconscious, starting from a brief repose, and screaming with pain or terror and clutching, flexor muscles of limbs, especially upper, were principally affected, muscles of spine occasionally contracted so as to jerk head backward, pupils dilated, pulse rapid and weak, skin dry, hot and covered with scarlatinoid redness. Violent delirium, tongue dry and brown, respiration labored and quick, with flapping of cheeks, twitching of arms and legs, catching at imaginary objects. Excitement, with congested skin, face, hands and whole body swollen, delirium, sensibility suspended, clonic spasms at times of limbs, pupils dilated, thirst, speech thick and clogged, tongue and throat swollen. Delirium, with absurd hallucinations, pulse rapid and feeble, skin flushed and dry, tongue dry and brown, thirst, throat dry.
Motion unpleasant, and if feet were lifted in walking the floor seemed to recede before thy were put down again, a sliding of the feet seemed the only safe way of locomotion, with dizziness and fear of falling, great thirst, but only a little water could be drunk at a time because swallowing was unpleasant, languid feeling, a semi-recumbent position was assumed, and whether sleep with wild dreams or waking hallucinations followed it was impossible to tell, but they were the opposite of those produced by Cannabis indica, for all the imaginations and conversations were of the long past, whether there was total blindness or imagination of blindness could not be remembered, but all the images were very distinct, the actions were performed by embodied spirits of those long since departed, and lengthy pleasant conversions were held with Plato, Alcibiades, Aspasia and others, sound sleep must have followed, for consciousness did not return till sixteen hours after taking the Atropia, then sudden waking, with nothing abnormal but languor and disturbed vision. Loud cries without pain.
Fretful. Desire to scold and quarrel, alternating with internal anxiety and fear, changing at last to anguish. Morose, quarrelsome, angry at trifles. Sudden fear of death, with nervous excitement and formication all over body. Apprehension after his internal restlessness, soon amounting to anxiety. Sadness; with anxiety, restlessness and fear of misfortune, or angry and inclined to be alone, seldom lively. Cheerful to an exaggerated degree. Indolence of mind; then vertigo, then beginning intoxication. Want of memory. Memory wrong, thinks what happened in the night of the 11th took place in the night of the 10th. Attention difficult to fix. Absent-minded; and forgetful, after partly finishing a sentence was obliged to inquire what I had been saying. Feels as if awakened from a dream. Confusion of mind when he closes his eyes, and all sorts of spectres. Dull and not inclined to move about or converse; when spoken to often turns his head to the wrong side. Unconsciousness; with incoherent talking; and irritability, striking his mother when she took him from the nurse. Comatose; and insensible, with dilated pupils and flushed and swollen face; with cyanotic and cool skin, pale face, livid lips, relaxed limbs, jaw hanging down, mouth and tongue dry, pupils dilated, insensible, respiration slow, pulse 90.
And face flushed and hot, with full, bounding, irregular pulse. Sticking in base of skull and especially over eyes on every motion and (<) Stepping. Feeling as if screwed up, and waking caused sticking. Aching; with vertigo, pain in back and nausea; with vertigo on sudden motion; sick headache, with pain in r. eye and r. temple. Fulness and discomfort; skull feels too small for brain, pain in vertex and over eyes, pain in all that part of head above eyes, head feels as if it would burst. Dull feeling, with feeling as if hair were matted into a thick felt. Confusion morning as after a disturbed night, (>) open air; dizzy, evenings; alternating with vivid phantasies, with general fatigue and at times ringing in ears. Intoxicated feeling, afraid to walk, must concentrate the mind to keep from falling, staggering.
Vertigo; in morning on rising, so that it became dark before his eyes; on waking; on waking, (<) rising, with confusion of head; on waking, with staggering towards objects for support; on turning head quickly; when attempting to walk; with wanderings of vision; with weight on vertex and over eyes; with pressure in temples, with little or no pain; with strange feeling in head, so that he could not see, throat deep red, sore, with inability to swallow; with heaviness, drowsiness or sleep, tendency to dreamy delirium and in women startings; intermittent; intermittent in forenoon.
Forehead.- Intermittent the drawing stitches across F. and temples. Aching; (>) closing eyes; headache beginning in middle of F.; in anterio-superior cerebral region; with vertigo on moving suddenly. Fulness, with heat of head; in anterior part of brain; in front part of head, with dilatation of pupils.
Temples.- Stitching in l. in morning on waking, extending behind ear, scarcely permitting him to open l. eye, (<) moving about in open air. Aching; and in eyes; intermittent, like a deep heavy pressure, and at other times tension in anterior cerebral region, as if brain pressed out in all directions. Pressure from without, (<) r. Bruised feeling. Fulness; in T. and forehead, with pain and with vertigo so that one can scarcely walk. Throbbing.
Pressure under parietal bones. Throbbing in vertex.
Restless. Projecting from sockets. Congested; and glassy. Fixed and glassy. Aching; and in head; and in temples; with lachrymation; in back part; with fulness and pressure in anterior part of head, making me restless, with sleeplessness till near morning. Swollen feeling, and the pain in eyes and temples (<) with each pulsation of the heat. Eyes and lids sore to touch. Dryness. Intolerance of lights. Weariness.
Pain in. l. ball. Pressure from without in every direction in ball. Pupils immovable; and dilated; dilated, with diplopia; dilated, with clouded vision, images confused, with a reddish tinge. Lids swollen; red and excoriated skin of lids; erysipelas of lids spreading to face and head; inflammatory swelling of mucous membrane of eyes, with muco-purulent secretion, often with swelling of lachrymal sac, occasionally with less swelling but more marked hyperaemia and lachrymation; lids heavy and difficult to keep open about 9 P.M., without sleepiness; lids ache; lids feel sore and are red. Glaucoma of r. Congestion; with dryness of the conjunctiva and aching in ball; erysipelatous inflammation and swelling of conjunctiva and lids; conjunctivitis. Sharp pain under r. eye, with aching in temples. Intermittent neuralgic pain under l. orbit running back to ear.
Vision and hearing morbidly sensitive; at night. Difficult vision with r. eye; D., of small, near objects. When talking with persons they suddenly vanish. After looking at objects a few minutes they become indistinct and fade away. Letters run together after reading a little. Eyes lost control o distance, print held at usual distance was blurred, at a long distance letters could be distinguished but words soon ran into confusion, distant objects were plainer than natural, but near objects soon became indistinct and light caused pain deep in balls. Partial blindness, with one pupil twice as large as the other. Partial color-blindness. Cannot estimate distance correctly. Staggering, catching at distant objects which appeared near and often stumbling over objects which appeared distant. Quick rotation and duplication of objects. Dim V.; with golden circles dancing before eyes. During the increasing dimness illusions of gigantic figures, whirls, double images, enlarged appearance of all objects and laughable or frightful appearance of all kinds. Dilplopia. The large figures on the carpet seemed to be constantly and successively rising to her face (perpendicular diplopia, the apparent object below the real one). Round or oval objects seem elongated; the vertical diameter of the human face seemed equal to the rest of the body, especially prominent were the nose and chin, with their margins enveloped in mist, next and pupils large and sluggish. Eyes of attendant seemed very large. Letters of a newspaper seemed to expand and contact with each pulsation of heart. Objects appear enveloped in a white vapor. Vision of many white flies on the door, which was was white, at night, continued till next noon, on closing eyes. Bright spots and stars and a brilliant glow around letters. Bright flashes at night on closing eyes. V. of black bug, with veritable legs, below a black door knob. V. in morning of a thousand-legged brown worm on carpet, the predominating color of which was brown.
Hearing sensitive, with frequent illusions. Roaring. Hears thinking bells. Ringing.
Mucous membrane dry. Sneezing caused by glaring light; and rubbing nose frequently.
Red; and hot; with white spots; afterwards pale. Pale; and sweaty. Expression of mania; of anxiety. Twitching, especially around mouth and lids. Mouth opens but little, masticator muscles are rigid. Lips swollen and hanging down; L. parched, and no relief from water.
Teeth and lips dry and covered with sordes. Teeth feel “on edge.” Tongue trembles when protruded; with light redness of tip and edges. Tongue coated dirty gray; white; whitish on margins and yellow in middle; T. thick, cannot articulate distinctly. Tongue dry; and coated; mucous layer dry, brown and hard; anterior part or whole; of dorsum, except a wide margin, dry, brown and rough; dorsum of T., roof of mouth and velum palati dry and glazed; feeling as “dry as chip,” though moist to sight and touch, and the throat seemed almost as if its sides were stuck together; and hard and soft palates, extending down pharynx and larynx, making voice husky and often inducing dry cough and difficult deglutition. Tongue and mouth dry and feverish and throat dry, (>) for only a short time by water, the dryness of throat increased, causing at first-frequent deglutition, afterwards strong effort to avoid swallowing, which had become painful. Tongue partially paralyzed. T. difficult to protrude and cannot be moved about in mouth at will. T. and other muscles assisting in speech difficult to move. Stuttering, especially at words difficult to pronounce. Slowness and embarrassment of articulation. Articulation indistinct, rapid and chattering. Speech thick, probably from dryness of mouth and throat.
Mucous membrane red. Hard and soft palates completely glazed. Thick, viscid or slimy mucus. Coating of viscid, slimy, white mucus. Mouth and throat feel as if she could not swallow, but she drank with avidity warm water, though it seemed difficult at first. Formication on palate. Buccal cavity feels hot. Dryness; at night, especially along median line and on each side of it. Hard and soft palates and back of oesophagus as dry and glazed as a piece of paper. Dryness; of M. and throat, with sensation of burning and choking and difficult swallowing; D. suddenly (>) by a viscid acid secretion, of offensive odor, like sweat of feet, that mouth becomes foul and clammy, with a bitter coppery taste; but no thirst, and inability to feel passage of water through mouth and throat. No sensation in M. and throat when drinking water except slight coldness. Loss of sensation in buccal cavity, with loss of taste.
Salivation. Taste slimy; sour; sweetish; to food lost; salt, to everything.
Mucous membrane dark and mottled. Fauces and uvula red. Drops of white mucus stick to vulva. Hawking of clinkers from posterior nares. Throat feels raw and irritated. Soreness; with pain on swallowing; increasing till hoarse. Burning; and in stomach. Dryness; (>) towards morning; and especially in gullet, so that he could not swallow bread and butter unless he took water; with pressure in anterior and superior cerebral regions; with constriction and desire for something sour and juicy, the D. and C. (<) by a sour apple; extending to lower passage of nares; causing constant inclination to swallow; causing inclination to cough, (>) swallowing water. Constriction. Fulness. Choking, then inability to swallow, with feeling as if seized by the throat. Throbbing, with feeling as if seized by the throat. Throbbing or heaving sensation in carotids. Swallowing produced spasms suffocation; swallowing appeared to give pain, manifested by grimaces and increased facial spasms.
Hunger, (<) eating; H. for salt food; constant but soon satisfied, food tasteless. Appetite lost. Aversion to met and beer, the beer aggravated the empty feeling in stomach and caused painful pressure. Thirst; with dry mouth and throat, perversion of sensation, everything tasting very acid; no T. in spit of dryness of throat. Eructations, empty; tasting like the yolk of eggs.
Nausea; in morning, with vomiting. Ineffectual; retching. Vomiting after warm drinks; after milk of food after dinner; profuse V. of colorless mucus, then of green, bitter fluid after the morning vertigo. Nervous and watchful for three hours, hurried from bed and vomited profusely a watery fluid, bitter at first, nearly tasteless, afterwards with sticking in umbilical region. Constrictive pain caused by beer, (<) walking, with eructations of air and nausea. Distress in epigastric region. Feeling in night as if the stomach had got a grip of the apple eaten in the evening and would hold it as in a vise. Sensitiveness to strong pressure. Soreness of pit. Discomfort. Burning. Uneasiness, with empty eructations, then with nausea and retching, increasing to a pressing sticking and contractive pain, with pallor and sweat of face, singing in ears and aching in forehead.
Tympanitis and tenderness. Tension; and swelling but not tympanitis. Pain in umbilical region, (>) copious watery, gushing stool.
Urging to stool. Paralysis of sphincters of R. and bladder.
Diarrhoea of yellow bile. Frequent watery, gushing. In the stool, fluid seemed mixed with urine. No stool for five days and then induced artificially.
Tenesmus and frequent desire to urinate; ineffectual desire; frequent desire with only a moderate quantity. Micturition prevented by spasmodic stricture, after long waiting void half a teacupful, stream no larger than a knitting-needle (stream ordinarily extra large large), inability to empty bladder, then only in drops, then complete stricture, the catheter drawing off a pint of normal looking urine. Micturition only after some trouble; difficult and in Micturition only after some trouble; difficult and in Micturition only after some trouble; difficult and in drops. Urine passed slowly and increased in quantity; U. retained. Incontinence of U.; and involuntary stool. Frequent micturition at night; and profuse almost colorless urine. Dysuria. Urine profuse; scanty; high-colored, turbid; acid, dark, brownish, without sediment and containing atropine.
Voice husky; lost; weak. Cough; paroxysmal, from mucus in throat, with difficult expectoration of thick tough mucus, after the cough burning in throat; periodic dry tickling, from speaking or smoking, with sore feeling in throat and pressure of chest. Scanty, thick, frothy, white sputa. Choking. Rattling inspiration. Rapid respiration.
Rales about base, pain over r. side of, cough, with rust- colored and scanty expectoration, dullness of chest as far as spine of scapula on r. side behind, tubular breathing and bronchophony, rough breathing over I. lung posteriorly. Warmth.
Fluttering sensation in cardiac region. Palpitation; at night, with great debility and distress. Action accelerated and pressure of blood increased by weak doses, the reverse from poisonous doses. Action irregular and apparently obstructed. Labored heavily and to my feeling at the rate of about fifty per minute, with sore feeling over base of heart.