Colocynthis homeopathy medicine – drug proving symptoms from Encyclopedia of Pure Materia Medica by TF Allen, published in 1874. It has contributions from R Hughes, C Hering, C Dunham, and A Lippe….

  Common name: Bitter apple.


Citrullus Colocynthis, Schrader (Cucumis Colocynthis, L)..

Natural order: Cucurbitaceae.

Preparation: Tincture of the pulp of the fruit.



After a bottle of Bavarian beer I felt much intoxicated; a most unusual thing. He could not, without difficulty, get rid of the idea that he was not in his own room, but in another. Disinclined to talk the whole day. Despondent, joyless, disinclined to talk. Extreme anxiety. Irritable disposition.

Excited, irritable state of temper; taciturnity. Extreme fretfulness; nothing seems right; he is extremely impatient, and angry at every word that he is obliged to answer, and becomes most painfully confused; everything annoys him, even the merest trifles. Morose mood; becomes offended at everything; is not inclined to answer. Return of the vexatious thoughts which he had forgotten, but which soon yielded to an unusual cheerfulness.


Dulness in the morning, with late waking and dislike to get up.

No inclination to search after and grasp objects of interest. He was somewhat confused by the beer drunk in the evening.

Difficulty in collecting his thoughts. A peculiar state of mind; I could not pursue any train of thought. Absentmindedness.

Unusual weakness of memory.


Confusion and Vertigo.

Confusion of the head. Confusion of the head, for an hour.

Confusion of the head, especially of the fore head. Confusion of the head, in the frontal region. Confusion of the head, most perceptible in the right frontal region, continuing the whole day. Confusion of the head, with pressure in the orbits, in the afternoon. Confusion of the head, most severe after dinner, nearly disappearing towards evening. Confusion of the head, with transitory attacks of vertigo; frequently recurring in the course of the day.

Confusion and gloominess of the head. Confusion and dulness of the head, as after a debauch. Confusion and heaviness of the head, with feeling as if a catarrh were coming on. Confusion in the forehead.

Confusion of the forehead. Confusion of the right side of the head, especially in the temple (after half an hour). Confusion of the left side of the head, with pressing burning pain in the left orbit, temple, and nose, on the dorsum nasi, and in the upper teeth; it seemed as if the eye and nose were swelling (these symptoms were clearly marked and persistent). Head befogged. Vertigo on suddenly turning the head, as if arising in the left temple; it seems as if he would fall; with tottering of the knees. Slight vertigo, in the evening. Sudden, very transient vertigo, with darkness before the eyes, in the evening, on sitting down. Frequent attacks of vertigo.

Symptoms of vertigo, soon after breakfast, when walking rapidly.

Intimations of vertigo and nausea. (40). Almost giddy for a few minutes, after dinner.

General Head.

Head a little affected, soon after the dose.

Dulness of the head, early in the morning, especially in the frontal region; returning in the forenoon, when walking. Dulness and vertigo in the head, with commencing colic. Stupefied feeling in the head, after dinner, lasting a few minutes. Heaviness of the head.

Painfulness of the whole head and eyes, very much aggravated by bend ing forwards. Painfulness of the whole head, most troublesome in the frontal region, aggravated by stooping or turning the head, with incapacity for mental exertion, continuing a few hours. Headache.

Slight headache, early, in bed. Considerable headache, in the evening. Violent headache. Violent headache, lasting half an hour (after three quarters of an hour). Headache very violent, as from a draft of air, disappearing on walking in the open air.

Transient headache. Pressing pinching pain in the upper part of the brain.

Sensitiveness of the head, during the whole day, as though it were compressed; especially in the forehead and temples, with painfulness of the eyeballs, aggravated by bending forwards; better in the open air. Boring in different parts of the head, right side (twenty second to thirty first day). Boring in the bones of the skull, especially on the right side (fourteenth to fifteenth day). Painful tearing digging through the brain, which became intolerably severe on moving the upper lid (after a few hours). Drawing and boring in the head, when walking (thirteenth to fifteenth day).Pressure within the head, paroxysmal, slight, now here, now there. Pain in the head, occupying the space of about half a crown, in the region of the linea semicircularis, about its middle; it felt like a kind of pressure.

Pressing headache. Pressive headache along the sagittal suture, more violent on moving or shaking the head, and on stooping. Tearing headache in the whole brain; in the forehead it becomes a pressure, as if the forehead would press outward; more violent on moving the head. The headache and pains in the knees and foot came on daily at about 8 a. m. and continued until afternoon, when a soft stool took place.


Heaviness and stupefaction of the forehead. Heaviness and pressure in the forehead, towards evening (seventeenth day).

Frequent attacks of painfulness and aching in the forehead and eye balls. (70). Severe boring burning pain on the right side of the forehead (eighteenth day). Transitory headache in the left side of the forehead. Boring on the left side of the forehead (twenty second to thirty first day). A great deal of boring in the forehead (fourteenth day). Frequent boring on the right side of the forehead (sixteenth day). Boring and tearing pains in the forehead, very frequently during the day, also in the evening (fourteenth to fifteenth day). Severe boring pains on the right side of the forehead (twenty second to thirty first day). Tearing boring pains in the forehead during a walk (sixteenth day).

Drawing in the forehead (twelfth day). Pressing drawing pain in the left side of the forehead.

(80). Pressure in the forehead. Waking after midnight, he perceived, as he lay on the right side, pressure and weight in the left side of the forehead. Pressing in the forehead and at the root of the nose, as though a violent catarrh were coming on; continuing three hours.

Violent pressing over the forehead, from the temples towards the nose, with feeling of dryness in the latter (after half an hour).

At 1 p. m.

A pressive pain in the left side of the forehead, occasionally slightly vibrating; it was clearly traceable in an arch which defined the lateral and superior boundaries of the left frontal sinus. Pressive headache in the frontal region (after half an hour). Pressive headache in the forehead, most severe when stooping, and lying on the back; lasting six hours. Drawing pressing pains in the forehead (twenty first day). Sudden, sticking pain in the forehead, towards the nose. Dull sticking pain internally in the forehead, in the morning, after rising (after a quarter of an hour). (90). Tearing in the forehead, during the evening. Tearing in the forehead (tenth day), in the left side (eleventh to thirteenth day); in different parts of the forehead, in the morning (twelfth day). Tearing in forehead, right side (seventeenth day). Severe and frequent tearing on the right side of the forehead (seventeenth day). Violent pressing throbbing headache in the forehead. Although the pain went off on sitting up and moving his head, still his head was very much confused all the forenoon.


Aching in both temples, aggravated at first in the open air, then entirely disappearing. Tensive headache in the right temple.

Boring in the right temple; severe boring in the left temple, continuous and frequently repeated, at 2 p. m. (fifth day); severe boring, as if from a plug, in the left temple, in the evening (eleventh day); boring in the temples (twelfth day).

Pressive painful digging in the temple. Dull pain in the right temple, aggravated by stepping; with a gloomy mood. Pressure in both temples.

Sensation of violent pressure in the left temple, continuing the whole afternoon (migraine?), better while seated, worse when standing and waking, but especially when urinating. Pressing and drawing pain in the right temple (after three hours). Pressive headache, early, in the temples. Feeling as if the temples were screwed into. Boring stitches in the right temple, disappearing on touch. Tearing in both temples several times repeated (fifth day); tearing in the right (seventh day);frequent tearing in both (eighth day); severe and frequent tearing in the right and above it (seventeenth day). Tearing and pressing in the right temple (second day). Pressing and dull throbbing in the left temple, growing gradually acute and cutting; with a similar sensation about the left shoulder joint.


Pain in the vertex and left eye, as if a nervous pressure (immediately). Tearing on the right side of the vertex (twelfth day).


Boring and drawing in the right side of the head, in the forehead (twentieth day). Drawing, one sided headache (after one hour and a half). Tearing in the head, left side (tenth day). Tearing in the left side of the head, towards the forehead (twelfth to fifteenth day).


Boring on the right side of the occiput (tenth day).

Violent, long continued pressure in the lateral occipital protuberances. Pressing and tension in the occiput, most sensibly felt at the inferior lateral protuberances.

External Head.

Roots of the hairs are painful. Burning pain in the skin of the forehead, above the eyebrows. Biting burning on the left side of the scalp. Drawing in the scalp. Soreness of the skin on the vertex, as though the hair on this part were constantly pulled upward, accompanied on the second day by a drawing pressing pain in the occiput; both symptoms disappear towards evening. Crawling and itching on the whole left side of the head, compelling him to scratch.

Itching of the scalp.


Eyes dull and watery. Feeling of dryness in the eyes, in the evening.

Smarting in the eyes; painfulness of the eyeballs. Severe itching in the right eye, obliging him to rub it.

Brow and Orbit.

Pressing feeling in the orbits, towards the root of the nose.

Fine sticking and drawing, varying in intensity, with aching, in the left orbit, and burning as if from pepper in the mouth, especially on the hard palate. Stitches above the right eye, accompanied by itching of the scalp.


Annoying twitching of the right upper eyelid, continuing four days. Heaviness of the eyelids, without sleepiness. Burning sensation in the right upper lid (after thirty four hours).

Biting burning beneath the upper eyelids. Exceedingly painful sticking burning on the edge of the left upper eyelid. A prickling burning pain in the right inner canthus. Transitory pressing in the right eyelid.

Burning cutting in the right lower lid during rest. Smarting pain in the eyelids.


Slight sticking in the conjunctiva palpebrarum of the left eye.

Next morning it was perceptibly inflamed; here and there were indications of commencing ulceration, which continued to increase till 4 in the afternoon, when it was complete; next morning cicatrization had taken place.


Burning pain in the whole right eyeball. Aching in the upper and outer portions of the right eyeball in the evening, aggravated by rubbing it with the finger; it feels harder than usual there.

This aching lasted some days. Painful pressure in the eyeballs, especially on stooping. Pain as from pressure upon both eyeballs from above downward. The left eyelid lay thick and heavy upon the ball, which felt as though squeezed anteriorly and superiorly.

Pain in the eyes; a sharp cutting in the right eyeball.

Stitches as with knives in the right eyeball, extending to the root of the nose.


Obscuration of vision. Mist before the right eye, early in the morning, lasting several hours; not removed by rubbing it. A great, white, very bright light was seen at the side of and below the right eye; but as he turned his eyes rapidly sideways, in order to examine it, it vanished. At 10 a. m. shimmering before the right eye, in the shape of a circle with rays, coming on a short time before getting up from writing. (Sparks before the eyes).



Drawing above the right ear (eleventh day); behind the left ear (twenty second day). Pressure behind the left ear, continuing a long time. Cutting sticking pain in the lower fossa of the right external ear, relieved by boring in with finger.


Feeling of warmth in the right ear. Sensation of obstruction before the left ear. Itching sticking deep in the ear, extending from the Eustachian tube to the tympanum; relieved by boring in with the fingers (after one hour and a half). Twinges in the right ear, not relieved by boring in with the finger. Crawling within the ear, relieved by boring in with the finger.


Difficult hearing. Transient deafness, at least every thing heard was accompanied by a roaring noise; nothing seemed to have its proper sound; lasting a few minutes. Frequent, long continued, and violent ringing in the ears. Constant ringing in the right ear. Roaring and feeling of obstruction in the left ear, going and returning rhythmically; the roaring soon changed to singing. Constant roaring and throbbing in both ears, especially in the left.



Sneezing. Frequent sneezing, with dryness in the nose.

Fluent coryza. Fluent coryza, in the morning, without sneezing.

(Fluent coryza, constant and uncommonly violent, with constant dropping from the nose, worse in the open air than in the room, for two days). Fluent catarrh, and frequent sneezing.


Feeling as if from an incipient catarrh. Severe boring above the nose (seventeenth day). Throbbing borrowing pain in the nose, extending from the left side to the root of the nose.

Violent itching in the left nostril, which provokes scratching, in the evening; with irritation as in coryza (after fifteen hours).



Redness of the face. The muscles of the face are relaxed and pale, the eyes seem sunken.


Tension in the left side of the face, extending to the ear, and into the head. Painful drawing in the face.


Aching pain in the left cheek. Burrowing burning pain in the cheeks, more during rest than motion. Constriction and pressing in the left malar bone, extending into the left eye. Persistent pressing in the right malar bone and eye. Transient stitches in the upper jaw, frequently recurring. Tearing in the cheeks (eleventh and twelfth days). Prickling in the region of the right cheek bone as though an eruption would appear.


Burning of the under lip. Burning and feeling of swelling of the under lip.


Twitching in the muscles of the chin during rest of the parts.

Boring in maxilla, right side, in the evening (twenty second to thirty first day). Severe boring in the inferior maxilla, 10 a.

m. (third day). Boring pain in the right lower jaw (eleventh day).



Painful looseness of one of the lower incisors. Feeling of the teeth being on the edge, which appeared in the evening, and was very annoying the next day. Heat and swollen feeling in the roots of the right lower teeth. Pain in all the upper teeth. Violent pain in a hollow tooth. Frequently repeated aching in an upper hollow tooth. Toothache on the left side. Toothache on the right side. Drawing in the upper teeth of the right side, with feeling as if the upper lip was swollen. Drawing in the lower incisors’ twitching pain from the left lower molars into the left arm, as far as the elbow. Violent drawing pain in all the teeth of both jaws, in the afternoon. The teeth of the lower jaw are painful, as if the nerves were torn and stretched. Sensitiveness of the incisor teeth. Sticking throbbing pains in the right lower back teeth, as from a beating with a wire.


Tongue red. Tongue coated white, with a sensation of rawness on it, as from too much smoking. Rough tongue, as if sand were scattered upon it (after thirty six hours). Burning on the anterior surface of the tongue. Burning upon the tip of the tongue, continuing several hours. Every exacerbation of the symptoms, without exception, began with burning at the apex of the tongue. Sensation on the tongue as if it had been scalded with a hot fluid, during the whole day. Sensitiveness of the borders of the tongue while eating.

Persistent, severe biting in the middle of the tip of the tongue, as if it were sore.

General Mouth.

Burning pain in the right corner of the mouth.

Scraping sensation in the palate, even when not coughing.

Beating pain in the mouth, in the right cheek, and on the side of the tongue.


Collection of saliva in the mouth. Tasteless saliva, like water, in the mouth.


Insipid taste in the mouth, after dinner, for an hour and a half.

Nauseous, bad taste, more in the throat than in the mouth.

Metallic astringent taste on the upper part of the tip of the tongue.

Bitterness in the mouth, for four hours. Bitter taste in the mouth, immediately; (soon). Bitter taste in the mouth, after drinking beer.

Intensely bitter taste in the mouth, for some minutes. The disagreeable bitter taste of the drug remained for several minutes in the mouth. Nauseous bitter taste. Persistent bitter, disgusting taste.

Salt taste of the mucus hawked up. The mucus raised had the bitter taste of the drug. Beer tastes remarkably bitter, at noon.

The taste of Colocynth. seemed very disgustingly bitter, it continued the whole day.



Constant hawking. Sensation as of a foreign body in the throat, as though he had to swallow over a lump. Dryness of the throat and hard palate, as though the parts stuck together.

Feeling of dryness in the throat. Fine sticking in the throat, as from grains of corn, on the upper part of the arch of the palate.

Feeling of rawness in the throat. Feeling of roughness in the throat. Scraping in the throat. Scraping in the throat, which is red in the region of the uvula; swallowing is difficult. Scraping and burning in the throat, and on the hard palate (as from pepper). A true angina set in, for which the prover took Belladonna, and subsequently Lachesis.

Fauces and Pharynx.

Sensation as of a ball as large as the fist rising up in the pharynx, with oppressed respiration. Fine biting stitches in the fauces; not noticed when swallowing. Sensation in the pharynx and soft palate, consisting of roughness and burning, continuing until afternoon.



An enormous appetite, at noon. Canine hunger. Canine hunger, with particular longing for bread and beer. Diminished appetite, though food has a natural taste. Little appetite at noon.

Little appetite at noon, none in the evening. Little appetite at dinner, although the food tasted well. No appetite for dinner.

Loss of appetite. (260). Loss of appetite, in the evening.

Appetite all gone.

Aversion to food before eating, and inclination to vomit, towards evening. Aversion to food, accompanied by scraping in the throat; it disappeared after drinking a glass of water; but the scraping continued. Strongly marked aversion to the drug.


Unusual thirst. Violent thirst. Unquenchable thirst.

Feeling of thirst in the throat. Great desire to drink, without thirst; the mouth is constantly watery; drink is relished but immediately after every drink there is a flat taste in the mouth.

Eructation and Hiccough.

Eructation, immediately. Eructations of bilious substances.

Violent eructation, immediately. Violent Eructations, lasting about half an hour (soon). Violent eructation, after eating.

Frequent eructations. Frequent, for the most part empty eructations, on rising from stool. Frequent eructations of breakfast.

Sobbing eructations. Empty eructations, etc. Empty eructations, which lasted almost the whole day. Empty eructations, frequently returning. Empty eructations, frequently repeated, and sometimes amounting almost to sobbing. Empty eructations, in the morning. Empty eructations, on rising up. Empty eructations, with burning in the pharynx. Empty eructations that cause palpitation and spasms in the throat, with desire to retch and vomit. Inodorous eructations (soon). Sour eructations (after a few minutes). Bitter eructations (immediately); (soon). Bitterish eructations from the stomach. Rising of a bitter, white, frothy liquid, immediately after breakfast. Hiccough (third day).

Frequent hiccough (after one hour and a quarter). Heartburn, after voracious hunger (after one hour).

Nausea and Vomiting.

(Nausea). Nausea; (soon). Nausea, for two hours (immediately). Nausea for eight hours (after five minutes).

Nausea rising from the stomach, for several days. Nausea for six hours, lasting until going to sleep at night, recurring in the morning, after waking. Nausea and malaise after eating, as from indigestion. Slight sensation of nausea, towards noon. Sudden and severe feeling of nausea, lasting about five minutes, and going off as suddenly as it came (after three hours). Intimations of nausea.

Inclination to vomit. Vomiting, very profuse. Vomiting of all nourishment. Vomiting twice, of only food, without offensive taste or nausea (after ten minutes). Vomiting of a bitter tasting, yellow, serous fluid.


Rumbling in the stomach, after each dose.

Feeling of emptiness in the stomach. Feeling of coldness in the stomach. Sensation as of a hank in the stomach and pharynx. A slight pain in the stomach, combined with headache, and also slight diarrhoea. Transient pains in the left side of the epigastrium. Burning pain in the stomach, even when eating.

Enormous heat of the stomach. Feeling of fullness in the epigastric region, in the forenoon. Transient aching contractive pain in the pit of the stomach, at 10 p. m., during a walk after supper. Compressive sensation in the epigastrium, returning at short intervals, and changing into a sharp pinching, with slight confusion of the forehead. Moderate pinching in the epigastric region. Griping in the epigastric region, after each meal, worse towards evening, lasting fifteen minutes.

TF Allen
Dr. Timothy Field Allen, M.D. ( 1837 - 1902)

Born in 1837in Westminster, Vermont. . He was an orthodox doctor who converted to homeopathy
Dr. Allen compiled the Encyclopedia of Pure Materia Medica over the course of 10 years.
In 1881 Allen published A Critical Revision of the Encyclopedia of Pure Materia Medica.