No treatment of an epidemic or endemic disease can result successfully that does not attempt to isolate a causative factor and then proceed to remove it. Hence, it is that some of our Southern STates and our National Government are now actively engaged in research work along these lines. Large sums have been spent by Italy, Austria, Spain, Portugal and Romania to stamp out this disease. A more careful supervision of the collection, storage and handling of maize products, enforced improvement in the hygienic surroundings of those affected, different climatic conditions when possible, and even segregation are advised. As regards individual cases, hospital treatment should be insisted on when possible, while tonics, a generous diet, massage, galvanism, the high-frequency currents, alcoholic and salt baths, together with remedies variously demanded, are to be thought of. Saline solutions, atoxyl, mercury, arsenic, thyroid extract and the various intestinal ferments have all had their trials but the specific remedy, it may be a serum, is yet undiscovered. Most writers who claim virtue for the indicated remedy, have had absolutely no actual experience in its use, hence I am not inclined to mention every remedy that might be collected by repertory methods but only those which I have had an opportunity to observe. Argentum nit., Arnica, Arsen., Bovista, Phosphorus and Ustilago may be studied.