STUDIES ON THE PATHOGENIC EFFECTS OF DRUGS
In guinea pigs and rabbits the isolated intestine perfuses in Tyrodes solution showed little or no change in amplitude and frequency of contractions. The general tonicity diminished, allowing the intestines to relax. This might be an explanation of the symptom “Great distention of the abdomen.” The isolated bladder showed a similar action except that the frequency of contraction diminished until it was lost in the general relaxation.