General Effects
Tonic contractions of involuntary muscle, particularly of arterioles, with dry coldness of the body and even gangrene of the lower extremities. Contractions of muscles of bowels and of the gravid uterus. Convulsions of voluntary muscles. Anesthesia and paralysis, especially tremblings and paraplegia. Contraction of arterial system predisposes to venous hemorrhages.
Generalities
Tremblings, with unsteadiness of the whole body, cramps, convulsions; epileptiform spasms. Wandering pains. Coldness, (<) heat. Restlessness, great debility. All the symptoms (<) heat.
Clinical. Collapse, with coldness and intolerance of heat; soreness of the body, dry flesh, tending to putrify. Universal aversion to external heat, with a sense of internal burning, often with unnatural appetite and thirst, but with perfectly clear mind. Aggravation from all preparations of Cinchona.
Mind
Raving delirium (rare). Anxiety, with fear of death, restlessness and difficult breath. In general, complete consciousness to the last breath.
Eyes
Sunken, with pale rings, often staring or distorted (dim vision results from the formation of soft cataract, with vertigo and roaring in the ears, in cases of poisoning.).
Nose
Bleeding.
Face
Pale, sunken collapsed face, with anxious look. Dark redness. with blue rings around the eyes. Formication of the face and whole body.
Mouth
Formication of mouth and tongue. Tongue swollen, paralyzed, speech difficult, imperfect. Salivation, with fetid breath.
Stomach
Unnatural appetite and thirst. Hiccough, persistent nausea and vomiting. Painless vomiting, without effort, of food of blood, or chocolate-colored matter. Anxiety and burning in the pit of the stomach, which may be sensitive to touch.
Abdomen
Tympanitic, burning or sometimes unnatural coldness. Colic, with convulsions.
Rectum and Stool
Sphincter ani paralyzed. Hemorrhage from the bowels. Diarrhoea, exhausting, offensive, burning or dark olive green, involuntary. Stools like cholera, with coldness, cramps, intolerance of heat.
Urinary Organs
Bladder paralyzed. Micturition involuntary. Urine may be suppressed or bloody.
Sexual Organs
Gangrene of pudenda, with fetid, black discharges. Uterine. hemorrhage. Violent contractions of the gravid uterus, followed by hemorrhage and miscarriage. Lochial discharge of puerperal women ceases, with fever. Metritis. Peritonitis.
Clinical. Uterine inflammation. Putrescent lochia. Puerperal fever. Though producing violent contractions of the gravid uterus, it predisposes to general convulsions when there is albuminuria and, in general, precipitates puerperal inflammation. It should be used during labor in physiological doses only when absolutely required by a great emergency.
Respiratory Organs
Haemoptysis, usually of venous blood, with difficult respiration, heaviness of the chest, anxious sighing, respiration.
Heart and Pulse
Pulse rapid, small, contracted, intermittent of fluttering.
Back and Extremities
Pain in the lumbar region, (>) stooping. Formication and numbness of the extremities.
Violent cramps. Tearing, drawing pains. Insensibility of the fingers and toes, with coldness and formication; they look wrinkled and pale, as if they had been soaked in water.
Skin
Ecchymoses. Swelling and pain, blue color, gangrene, especially of the lower extremities, with dryness. Formication under the skin.
Fever
Predominating coldness, cold dry skin, rarely alternating with burning heat, excessive thirst and cold clammy sweat.