Introduction
Alkaloid obtained from V. vir.
Provings
1. a. I took at Veratroidine gr. 1/60 in pill, pulse being 80. In 15 m. pulse was 78; in 40 m., 72. Dose was then repeated, and in 20 m. it was 76, in 30 m. 72. I then took gr. 1/30. In 15 m. pulse was 70, and continued so at 30 m., when I took gr. 1/29. In 15 m. it was 76, in 30 m. 72, in 45 m. 70, in 60 m. 68. I now ate a hearty lunch, with two glasses of claret; and 2 hours after took gr. 1/12, pulse being 80. In 30 m. it was 92. in left h. 72, in 1/1.2 hours 80.
1 b. I now took gr. 1/30 of the alkaloid from V. album, pulse being 70. In 30 m. it was 72, when I took gr. 1/20. In 14 m. it was 66, in 30 m. 62, in 40 m. 67, when I took gr. 1/12. In 20 m. pulse was 69, in 35 m. 64, in 1 hours 62.
In neither experiment was there any unpleasant feeling save a slight depression or languor.
1 c. As above experiments were made 2 hours after eating, I took gr. 1/20 (from V. viride) 4 hours after eating. In 1 hours 20 m. pulse was not materially affected, but about 3 hours after dining a feeling of depression and weakness came on, accompanied with tingling of tongue and lips, which continued for some hours, and was exceedingly unpleasant. (PEUGNET, loc. cit., p. 129.).
Experiments on animals
The influence of V. on the animal may be summed up as follows: a. Locally it is somewhat irritant.
b. It is an irritant emetic and sometimes cathartic.
c. It exerts no direct influence on the brain or on the pupil.
d. It is a direct spinal motor depressant, producing death by asphyxia, and acting at the same time to some extent upon the conducting nerves and the muscles.
e. It depresses the heart’s action both in force and in frequency, but the period of depression is followed by one of reaction, its primary cardiac action being independent of its spinal influence. (H. C. WOOD, loc. cit.).