Introduction
A white crystalline principle found in S.(chemical formula unsettled).
Provings
1. PALOTTA took 2 gr.without effect, but found 6 gr.to occasion gastric uneasiness and slowing of pulse; from 8 gr. he had nausea and constriction of throat; 10 gr. further produced sense of general debility, and, after 1/2 h., perspiration; 13 gr. gave rise to moderate vomiting of a bitter liquid, with irritation and constriction of throat, faintness, and general exhaustion. (Journ. de Pharm., x, 543.)
2. BOECKER found that Sm. is neither diuretic nor diaphoretic; and similarly negative results were obtained by him from the root itself. (Journ. f. Pharmacodynamik, ii, 30.)
3. CULLERIER gave Sm. to 9 syphilitic patents. In doses of 6 gr. the stomach readily supported it, but 9 gr. caused weight at stomach and nausea. (Journ. de Chim. Medorrhinum, 2 nd ser., I, 45; from Pereira.).