2 b. One dr. 3rd. dil. e. Feb. 8th. The urine has a strong smell of violets after 6 m. Dreams of travelling and desire for coitus, on waking has a strong erection. – 9th. Cross, sleepy, lazy, frequent yawning and stretching arms. – 10th. Hawking of mucus mixed with blood, evening-11th. For 2 day quivering of eyelids and indistinct vision. Watering of eyes and dull pressure in left eye. Frequent spasmodic twitching in left eyeball. Ears stopped as if a skin were stretched over them, this goes off for a short time when he puts his finger in the ear and shakes it. – 14th. Urine dribbles away when walking. Toothache in a hollow tooth, as if it must be pulled out, with cold feeling in cheek, relieved by open air and cold water taken into mouth, and by eating, drinking, and smoking, but in the evening in bed the pains increase, with throbbing and beating in left eye, left temple, and cheek. – 18th. In left ear a distant voice like “Wee, wee,” the hearing dulled, in bed, evening – 19th. On driving out, evening, vertigo, he fears he might fall. – 20th. Vertigo as if intoxicated, he staggers and must support himself, with attacks of faintness, pale distorted face, and sweats of anxiety, so that his shirt becomes wringing wet; on driving out immediately after breakfast he must immediately return home, when he vomited and became so weak that he must go to bed. – 21st. A fit: almost constant vertigo, all turns round in a circle, so that he must keep his eyes almost constantly closed; this is followed by nausea, with outbreak of sweat all over body and then vomiting of all he had eaten, though he had relished what he ate. After the food had been vomited he threw up water and mucus without taste, and, lastly, acid water. The attacks were most violent an hour after breakfast and dinner; thereafter extreme weakness with much thirst for cold water, which was always vomited; the taste was flat and insipid, though the tongue was not furred; stool soft, copious, tinged with bile; shooting in chest anteriorly as from displaced flatulence; sense as of board before forehead, later feeling as if a warm hand pressed forehead on to the pillow; at same time frequent hiccup and eructation; head very stupefied, cannot collect his thoughts and often is in half slumber, he must lie quite still; the vertigo is increased by moving and rising up in bed; the urine is scanty and reddish; discharge of flatus relieves his state. These attacks were repeated every hours or hours and half, for 48 hours, but he had several hours of sleep at n. – 22nd. Turbid urine with brick – dust sediment. Great heaviness in occiput, occasional undulations in brain, flapping in both ears, twitching and pressure in both eyeballs. While the nausea was passing off, there came on in a hollow left molar a drawing, shooting pain, and throbbing in right ear. (SCHERETER, N. Archiv, iii, 2, 184.).
Experiments on animals
I. RABUTEAU experimented on 7 middle – sized dogs, introducing 10-50 centigr. of selenite or seleniate of potash or soda (diluted in water or milk) either directly by intra-venous injection, or through the stomach. The animals died, but whether 1/2 hour after introduction of the poison into the system or some day later, all expired with symptoms of asphyxia. Lungs were found extensively and intensely congested, air-tubes injected, trachea choked with froth, and blood in arteries dark-coloured. (Elements de Therap. et de Pharmacologie. 1872.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.