Alternate apathy and intellectual activity, with heaviness of head; pressive pain in orbits, so that he could not keep head erect; bad taste, with loss of appetite; constipation for 10 day, faeces hard and voluminous when they do appear; pains in 3rd and 4th ribs, with great apprehension of heart disease (lasting for about 3 mos. after suspension of drug); fixed pains in small of back (rachialgia); pains in diaphyses of all long bones, especially of humerus; wandering pains; exacerbation of all symptoms in stormy weather, about midnight and at 3 p. m., amelioration in fresh air and out of bed; eruptions similar to crusta lactea, on forehead and hands papular eruptions changing to vesicular, with the depression as in smallpox (lasting 7-8 d.); sleeplessness; sleepy in daytime, sleep disturbed by strange and frightful dreams; horripilations between shoulder-blades, p. m. or evening; chills, heat and sweat, at 5 p. m. (in a lady). (II Dinamico, 1871.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.