6b. Abdominal cavity. – Acute peritonitis, arborescent injection on intestines, which are tympanitic and empty, especially the large; ascending and transverse portions much injected, with large reddish – brown spots on their surface, indicating incipient gangrene. Mucous membrane of caecum partly detached; ileum much injected, jejunum less so; duodenum only inflamed at pylorus; surface of the stomach little injected. Stomach. – At opening bright red, with injection over whole of large cul – de – sac; mucous membrane bloated; lesser cul – de – sac less injected. Pyloric orifice choked by an oedematous puff of a bright red; cardiac equally inflamed, and congestion extends to extremity of oesophagus; interior of buccal cavity red, with spots such as above named. Spleen a little congested. Kidneys congested; no urine in renal pelves. Liver, nothing peculiar, vena portae contains some clots. Gall – bladder, very little bile. Respiratory organs. – Lungs injected, crepitating, float well. Trachea normal, some ganglions congested. Larynx, mucous membrane slightly oedematous. Circulating system. – Heart very bulky, right ventricle contained a very blood – clot, fibrinous at upper part, and entangled in tricuspid valve; auricle contains a small blackish clot; numerous clots in pulmonary artery. left side normal, except a marked violet tint on columnar carneae; slight endopericarditis. Brain. – Considerable effusion of bloody serosity between brain and dura mater; injection up to edge of anterior lobes. Vieussieux’s centrum ovale pointed. Ventricles, serous effusion abundant. Cerebellum normal, except peduncles, which are injected. Spinal cord. – Marked injection all the way to cauda equina; at edge of olivae there was some serosity indicating inflammation. (Ibid.)
7. A dog above 10 months was poisoned with 30 dr. of the alcoholic tincture in 100 grammes of distilled water. The Ist day anxiety, agitation, nausea, burning thirst. The 2nd day 40 grammes of tincture mixed with broth; same symptoms, with tottering gait besides; can no longer run, but drags along; after this he reels and falls if forced to walk; trismus. The 3rd day the animal is better, and we let him rest. The 4th day at 7 a. m., 20 dr. of fresh juice mixed with his broth. Almost immediately violent shaking of head and limbs; same nausea and vomiting; extreme prostration; fetid and frequent stools. At 11:30 he died. A post – mortem took place and nearly the same alterations were found as in the preceding case. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.