4c. Oct. Ist., 1853, at 5:30 a. m., took I dr. of Ist dil. on sugar of milk washing it down with water. In a few m. uneasiness about umbilical region, and in a short time slight pain in front of right thigh, which soon passed off; also slight pain in left frontal eminence. Slight nausea and empty eructations during forenoon, and occasional twisting pain in umbilical region. Took another dose at n., and a third next m., without noteworthy effect. Repeated same on n. of 2nd, and m. of 3rd.; 1/2 hour after later slight fulness and pain in upper forehead, and in 2 hours slight shooting pain in left tonsil. 3 p. m., slight headache, dulness of spirits, tormina in lower bowels with desire to evacuate them. continued same doses up to 7th. In m. of 5th slight pain and fulness of upper forehead and peculiar stringent sensation in pharynx; also nervous sensation about heart; and several times in course of day clogging up of larynx and trachea with thick tenacious mucus; frequent sharp griping about umbilicus. After m. dose of 7th rather severe and steady pain in left frontal region, and slight nausea.
4d. Nov. 11th – 14th, took I gr. of Ist trit. n. and m. Soon after Ist dose slight pinching sensation in stomach and slight pain in forehead. After 2nd, peculiar oppression about heart, and slight pain in one tonsil; also darting pain running across forehead. After 3rd slight spasmodic pain in stomach and sense of scraping in throat; next m. on waking pains between shoulders, which continued all d. Nausea after last 3 doses, with same feelings in throat and stomach, and slight frontal headache. Pain between shoulders increased all 14th, and continued till 16th; it was worse on moving arms. for last 2 day urine in m. thickly loaded with red sediment, which gathered like a cloud at bottom of vessel, and seemed mixed with mucus. Repeated dose n. or 17th and m. of 18th. After Ist dose griping in stomach, and after 2nd return of pain between shoulders. Dec. 7th – 21st. – Took this dose every m. soon after Ist dose, nausea and pain in brow, audible beating of heart, and sense of depression. In course of day, while busily occupied, attention was arrested by heavy dragging sensation in spine between shoulders; it lasted about 1/2 hours, and caused much uneasiness. During whole day nausea and depression of vital energy to unusual degree. 8th. – After dose, while warm in bed, several fits of coughing, with peculiar sensation about fauces and larynx; slight nausea. Thereafter, slight frontal headache was a constant symptom; on 2 m., cough with taste of blood in m. Large painful pimple on brow. Much scurf on head. Pain as before between shoulders. (Brit. journ. of Hom., xi, 593 and xii, 244)
5. a. G. E. STEWART, aet. 24. Took, Oct. Ist – 6th, 1853, I dr. of Ist dil. m. and e. In 1/4 hours after Ist dose, felt irritation in larynx, as from inspiring acrid vapour, with warmth and rawness, causing hoarseness and tickling cough; this continued till 1 p. m., and returned about 4 for some hours 10:30, sensation for some time on small spot about left palate as when aconite has been chewed; head heavy, with dull confused mental state; frequent yawning – these last continued till I, and at 4 headache returned, with numbness in hands and crampy pains in left palm, also shifting aching specially felt in shoulder – joints. 2nd. – After retiring last n. much troubled with flatulent colic; and both then and this m. for I hours after rising stinging, aching, somewhat burning pain along right side of penis, as if immediately under skin. Mouth dry this m. on waking. Same sensations in larynx and head followed m. dose, but less strong and lasting; also, tightness in upper chest; pains as yesterday, drawing and shooting in left elbow – joint being severe; occasionally during day transient stitches in hypochondria and aching round loins; for 1 – 2 hours after dinner anguishing pain in left hypochondrium and loins, and flatulence. This pain, in loins and abdomen generally, came on again for about an hour after going to bed. 3rd. – Laryngeal symptoms very slight; occasional colic and flatulence, not so bad; once or twice considerable uneasiness in upper chest, not lasting long. After evening dose pain in left lumbar region, with occasional stitches, spreading over whole abdomen and to right groin, eased by bending forward; dull stitching in right face for a few m., and same in upper chest, ankles, and lower third of thighs (not in knees); transient vertigo, followed by “stounding” pain in right head. Went to bed with these pains in head, loins and abdomen; but woke on 4th free from them. After m. dose, almost immediately irritating, raw, rough pain in windpipe, which increased rapidly and was very annoying, giving rise to frequent. severe, hard cough, which made him quite giddy, and caused noise in head and pain in chest; slight hoarseness; severe dull frontal aching, with stoundings, not increased by cough; dull pain in right hypochondrium and lion. These feelings continued pretty severe for 1 1/2 hours, then gradually decreased till 1 p. m., when he felt well, save for dulness in head, and occasional dull pains in abdomen during d. After evening power (7 p. m.) laryngeal irritation returned, but with little cough; dull aching counteractive pains in chest; chilly creeping over left foot and leg; usual slight headache; occasional crampy pains in thighs, shoulders, and nape; numb pain in hands. 9 – 12, heaviness and dull pain in eyes. with suffusion, then tired aching, though they had not been much used; severe frontal headache; hot sore feeling of lips; creeping itching in various parts of body form time to time; aching in loins. 5th. – Few and slight symptoms to – day, which was much warmer than any since commencement of proving. – Same, in spite of raw chilliness in air, during d,; but all symptoms recurred in some force in evening, with momentary but very violent shooting pain in right side and dull aching in many joints. 7th. – Woke with laryngo – tracheal irritation, which continued for an hours or more, with hoarseness; much flatulence; aching in loins.
5b. Took 3rd dil. in same way for a week in Nov. There was a recurrence of all the previous symptoms, but only to a slight degree; irritability of larynx, especially on exposure to cold air, being most marked. (Ibid., xii, 215.)
6. a. M. C., Woman, aet. 38, proved drug under superintendence of Dr. Stewart, and in same way. After Ist dose, taken 15 m. before breakfast, felt sickish from feeling at pit of throat; nausea, with disagreeable sensation about stomach, headache above eyes, belching up of water, and flatulence, continued till midday. P. m., began to feel pain in throat again, also severe throbbing headache (frontal). In evening acute pain in small of back for 2 – 3 hours, hot skin, and pain in a small cyst she has in neck. 2nd. – Clammy mouth in m. and horrible taste. After m. dose feeling in pit of throat as if skinned; burning heat in face at different times in day, with flushing; headache all day, but very slight save for a short time about 3 p. m., when it was severe and throbbing. 3rd. No symptoms during day; but after evening powder severe gnawing pain in lower part of back, worse after going to bed, and keeping her awake some time. 4th. – Took dose at 8:30 a. m. Soon after breakfast very bad headache, especially acute over left eye, for an hours; rawness in throat for several hours; frequent yawning; hot pain at back of eyeballs; pain shooting through from left scapula to front of chest. After evening dose, recurrence of all these symptoms with burning in face, especially left side, and slight flushing. Thought of giving over taking drug, on account of the violence of the headaches caused by it. 5th. – Woke this m. with very bad headache, and great noise in the ears as if a mill were going in the head; slight pain in loins. By 9:30 aching and noise were almost gone, and little effect was produced by the day’s doses. On 6th, however, after m. dose, headache was very bad, and there was disagreeable feeling in stomach.
6b. Nov. Ist – 6th M. C. took I dr, of 3rd dil. m. and e. Beyond slight headache on first and last day there was no effect. 12th – 15th, took I dr. of Ist dil. (a new preparation) m. and e. During these day some of the old symptoms recurred, but only slightly in comparison. Dec. 12th – 17th, took I dr. of 6th dil. in same way, with still less effect. (Ibid., p.248.)
7. a. Dr. CRAIG began Aug. 12th to take I gr. of 2nd trit. at 7 and 11 a. m. daily. Little effect was observed till 15th, when he had, 10 a. m., uneasiness about heart while walking; 12 dull pain to right of sternum, immediately behind 3rd rib, passing under sternum – the spot tender to touch; chest tight across upper part; 2, after a moderate walk heat and uneasiness in left chest, with aching pain, felt particularly about 2 in. below middle of left clavicle. 6, dull heavy pain over lower half of right chest, with stabbing on inspiring deeply, which causes short cough, but no aggravation by movement; in bed could not lie for a. m. on left side, but pain and breathing were much relieved by lying on affected side. Took dose of bryonia 3. 16th. – Chest much easier, but cannot expand it without considerable stabbing pain; dulness on percussion distinct as high as right nipple. Noon, chest comparatively easy; took a dose. 17th. – 8 a. m., r chest quite easy, some aching in left chest in front. Noon, aching sticking in left side much worse, seems more diffused and external. 4, cannot ride and can scarce walk for the pain; has to press left & side with hand and bend that way; on attempting to walk fast it is as if there was a broken rib tearing lung; on attempting to breathe deeply there are horrid lancinations in all directions though chest, and short puffing cough, which also recurs spontaneously every m. 8, chills and partial heats, and general feeling if being unwell. 11, considerable fever with partial chills; left side as before; resp. 34, pulse 98; again can lie only on affected side. 18th. – Slept well, and felt much better in m., though there was still cough and considerable pain in left side. 19th. – Chest much better, can take breath and cough without much inconvenience. 20th. – Quite well.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.