8a. Dr. LELAND WALKER, in good health, nervo – bilious temp. Nov. 25th – 27th, 1865, took Ix dil. several times daily in doses rising from 10 to 60 dr., without appreciable effect; but on 28th woke with dull heavy pain in forehead and through temples, worse when stooping or moving about; pulse 51, feeble and irregular. This day took 4 doses of tinct., 20 – 30 dr. 29th. – Slept well; in m. pulse 60. At 7:30 took 50 dr. 12:50, has felt dull and drowsy for last 2 hours; dull heavy pain through front part of head, worst in left temporal region; increased appetite; unpleasant fulness in stomach an upper abdomen; felt better in open air. 6, constant hunger, yet sensation of fulness, as after a hearty meal, though he had not eaten since I; pulse 70, full and strong. II pulse same; dull pain in head and eyes all evening, and drowsy stupid feeling, save when walking in open air. Took 60 dr. before retiring. 30th. – Sleep unusually sound; woke with same headache and hunger, pulse 56 and feeble. At 8 a. m. took 60 dr. 3:30, dull aching all through head and in neck; aching in upper and lower extremities; several times during last 2 days sharp piercing pain on inner side of left knee, passing off quickly. 9:40, craving hunger, fulness of stomach and abdomen; head symptoms less severe. Took 100 dr. Dec. Ist. – Pain as before in head, with pain and stiffness in neck; dull pain in all extremities; pulse 52. Restless n., much dreaming. took 140 dr. 11, pain all through head, quite severe in temples, with throbbing in superficial veins, attended with semi – stupor; pulse 75. I, symptoms somewhat mitigated; dull dragging pain in small of back, quite severe at times; increase of urine during last 3d.; constant craving appetite, with fulness as before; pulse 66. 10:30, symptoms continue; pulse 62. 2nd. – Woke with same pains in head and back; pulse 72. 12:50, same drowsy stupor as yesterday. Symptoms continued all day 3rd. – Woke with usual pains; pulse 78. 6 p. m., has had drowsiness attended with vertigo most of day, and hunger with fulness as before; pulse 76 (before eating). II, pain in back and under left scapula; head same pulse 65. Passed 31 oz. of high – coloured urine during last 24 hours, sp. gr. 1020. 4th – Same symptoms; eyes felt swollen and had yellowish tint; stool (hitherto quite normal) lighter – coloured than usual; sharp pain once in region of heart, lasting a few m.; pulse 71 in m., 56 at noon, 61 in e. Passed 43 oz. of urine during 24 hours, colour nearly normal. 5th. – Same state; stool as yesterday; pulse before breakfast 54, after 71. 12:50, coldness of lower extremities, with pain from knees down. Passed 36 oz. of urine to – day, colour nearly normal, sp. gr. 1013, light – coloured sediment after standing. 6th – Woke feeling (for first time since beginning proving) quite well; but stool and urine as yesterday in appearance, sp. gr. of later 1028. 7th. – Well save for sediment in urine. On 8th this had gone; but on 9th sp. gr. was 1035, and on 10th 1029. After this it became normal.
8b. Having taken no M. since Dec. Ist, and being now quite well, Dr. W. began, Dec. 14th, to prove the pulverised bark, of which that day he took 5 gr. without effect. 15th. – Took 10 gr., but felt nothing save some dull aching in small of back. 16th. – Woke with same, and also frontal headache as before. This went off during day, but back continued to ache, and throat was somewhat sore. 17th. – besides aching in head and back, hunger and fulness have returned. At 8 a. m. took 20 gr., and put some moistened with water on posterior part of forearm. Throat sore still to – day, and urine dark – coloured. 18th. – As yesterday; throat feels swollen, and stool is rather light. 19th. – Woke in same condition; took 40 gr. at 7 a. m. Nausea and gagging soon after dose; light stool, and dark urine with pinkish brown sediment. 20th. – Same. Stool loose and light. Took 80 gr. Constriction and much string mucus about throat; drowsy stupor and deficient concentration of mind; urine same (21 oz. only), and sp. gr. 1030. 21st. – Woke tired; scalp sore to touch; head more dull than painful; eyes heavy and weak. At 9 a. m. took 160 gr. Symptoms much as before; no stool; urine dark, 1032 (20 oz.). 22nd. – Restless n. till 2, then slept till 7; woke with dull pain in head and eyes, latter congested and yellow; back and throat same; no appetite, tongue furred; bad taste in mouth and nausea. Pappy stool; urine high – coloured and frothy, with considerable sediment, sp. gr. 1031 (19 oz.). 23rd. – Restless night; symptoms of head, throat and back continued and increased; passed this m. 3 1/2 oz. of very high – coloured urine, looking like strong beer, with large amount of froth of yellowish tint, sp. gr. 1032. Left home, feeling miserable and dejected; and returned in same state on evening of 27th. Urine had been very scanty, high – coloured, and frothy. 28th. – No appetite, could eat no breakfast; dulness and heaviness of head and eyes; pain in back and hepatic region; felt sick and weak all over; conjunctivae congested and yellow, face and neck yellow; frequent eructations of flatus, relieving pressure in stomach for a short time only. 29th. – Woke from unrefreshing sleep with exacerbation of all symptoms; bad taste in mouth; tongue thickly coated, dirty – white or yellowish; throat and nares filled with offensive tenacious mucus; whole surface of body has yellowish tint; loathing for food, strong desire for acids; soft clay – coloured stool; chilly when out in air; aching in limbs and all over body; urine same. Continued same up to Jan. 5th; since Ist took medicines for the jaundice, but without effect. On 5th began digitalis Ix, 5 dr. every 3 hours; improvement began next day, and continued till 20th, when he was well but weak. [Prover mentions that during some part of the time in which he was experimenting a sort of jaundice was epidemic in his city; but justly points to the other symptoms and their occurrence in both trials as evidence that his whole illness was caused by the drug. – EDS.] (HALE’s New Remedies, 2nd ed.)
9. I have taken I dr. of the Ist dil. n. and m., for the last 7 or 8 d. During this time my bowels have been rather more active than usual, and the colour of the excreta much lighter, i. e. evening of a brighter yellow than usual. I have noticed no other effects which might not be incidental. (SHARP, M. Hom. Rev., 749.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.