7. Dr. KEYES, perfectly well, counted his blood – corpuscles (red) and found them up to his usual average (4,775,275). He then took gr. 1/5 of merc. iod. 3 times a day for two weeks, beginning Sept. 10th. On the 20th he found the corpuscles 5,572,200 in number. On the 24th, having been up greater part of n. with a patient, and feeling no appetite for breakfast, they were 5,175,875. Next day, having slept well, and appetite returned, they were 5,562,062. (Amer. journ. of Medorrhinum Sc., lxxi, 36).
8. Same gave to a patient with chancroid. gr. j of same daily for 4 mon. At end of time his corpuscles were 5,365,125 (average being 5,000,000). Three weeks later, dose having been gradually diminished to gr. 1/5, they were 5,302,375. (Ibid.).
Experiments on animals
1a. j was administered along with food to a pointer dog at 4 p. m. The consequences were, – vomiting, with black semi – fluid alvine evacuation in course of night; glassiness of eyes and thick ropy discharge from nostrils by 3rd day; and about close of 5th day prostration, and regular slow motion of extremities to and fro at each respiration. On the succeeding n. the animal died. Up to the last day he was able to stand, showed no want of appetite, and had not suffered any perceptible sensorial derangement.
1b. Dissection exposed to viewed a half decolourised coagulum in left ventricle of heart, and a little dark semifluid blood in right; strong prominent corrugation of lining membrane of stomach, with redness of apices of rugae, dotted red patches at sides, and a string of extravasated blood in every furrow. (COGSWELL, Iodine and its Compounds, p. 160.)
2a. j was given to a strong male rabbit at 9 a. m. In a few hours animal voided a copious semifluid stool; the day following he was affected with tremors and debility, and gave utterance to low plaintive cries in course of n. succeeding which death took place. Shortly before this he passed a scanty semifluid evacuation.
2b. Lining membrane of stomach was excessively injected about 1 in. from pyloric orifice, and presented a small quantity of extravasated blood upon its surface. Its contents were soft, blackish green, and homogeneous, as were those of the small intestines. Rectum and bladder were empty. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.