2. I poisoned a large dog with the cyanide, by injecting some of the crude drug under the skin. the symptoms were – nausea; vomiting; excessive thirst; many stools, of what I tool to be blood but proved to be bile and mucus, with much tenesmus; respiration very slow, the last hours before death about 1 per m.; dilatation of pupils; intermittent pulse, beating twice, then stopping once, then beating 5 times and stopping twice. The dog had no pain, but was in a listless state, with excessive and complete prostration. Post – mortem examination revealed inflammation of the larynx, with its mucous membrane and that of the posterior nares loaded with mucus; cardiac portion of stomach highly inflamed, the viscous containing about a pint of bile and mucus; whole intestinal tract filled with bile and rectum congested; liver highly congested; both ventricles of heart filled with dark blood, in right a white fibrinous clot. (BURT, Amer. Homoeopathist, ii, 29.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.