7b. On 19th began to take 2x. After 10 dr., in 2 hours heavy dull pain in lower occiput, worse on left side; prostration of strength, even a short walk causing weariness, hurried breathing, and palpitation. These symptoms lasted 4 day, headache going off first. On 24th, repeated dose. Same symptoms, with pain in cardiac region and anxiety. These symptoms lasted 5 days, becoming less severe each d. On Jan. 5th took 1x, and repeated it at n. without any effect. On 6th repeated dose. In about 2 hours return of symptoms of head and heart, with weakness, which lasted 3 d. After this repeated same dose with like result. On 13th took 10 dr. of tinct. This caused headache and suffocative feeling. Repeated dose next m. About noon there suddenly came on throbbing pains in forehead and vertex; then pains in chest and around heart, increasing in severity as those in head became less, heavy pressure on chest, hurried breathing, and great prostration. The symptoms became so bad that he was obliged to go to bed; for 1/2 hour after so doing could only breathe with great difficulty, and with pains about heart there was severe palpitation. This condition remained at its height for 2 hours, and then gradually abated, so that he was able to get up in the evening and study. For two weeks subsequently he had the headache almost every day about noon, and the exhaustion had barely disappeared by the end of this time. (Am. Obs., xiii, 345.) 8. Dr. W. IRVING THAYER, aet. 39, in perfect health, save that he has 3 papescent stools daily. July 20th, 1875, took repeated doses of 5 – 30 dr. of 1st dil. without effect. 21st. – Same result from 1x dil. taken in same way (up to 60 dr.). 22. – Made a tinct. of 1 to 5, and took it after same manner, without effect; but his sleep for this and the last 2 n. was early and profound. 23rd. – At 9 a. m. 5 dr., and at 10 a. m. 10 dr. of tinct. In 1/2 hours after last dose dull heavy distress in pyloric region of stomach, as though some hard, indigestible substance were lying there. At 11:30, 10 dr., followed by same symptoms, but most acute. At 2 p. m. 5 dr., and at 4 p. m. 10 dr., which last in 20 m. slightly increased pain in stomach; but a full meal at 5 at once relieved it. 24th. – Two stools to – day instead of usual three, first constipated. At 9 and 10 a. m. 15 dr., and after 2nd dose distress at stomach, – a burning pain rather than the dyspeptic ache he experienced yesterday. At 11 a. m.35 dr., and at 9 a. m. 40 dr. This m., also yesterday, noticed bright red spot on right cornea, near iris; and in both eyes a vascular appearance, as from cold or overwork; pupil normal. 25th. – In usual state. 26th. – At 8:30 a. m. 30 dr., at 10:30 a. m. 30 dr., and at 2 p. m. 80 dr. In 1/2 hours after last dose, copious perspiration; pulse (normally 80) 108; temp. 97 degree. At 3 p. m. 30 dr. At 5, overpowered with sleep while reading; slept 1/2 hours; after waking, found cornea injected and quite red. 27th. – Eye less red. 28th. – At 2:15 and 3:15 p. m. 75 dr. After 2nd dose pulse 94. At 4:15 p. m. 100 dr. In 1/2 hours gentle glow on face, as from exposure to sun and wind; slight increase in colour. 5, white of eyes vascular again. 29th. – For last 3 day stools have come only twice daily, but of same consistence. On 30th two stools, but exceedingly difficult to evacuate, consisting of long, large, and very dark faeces. 31st. – Between 6:30 a. m. and 1 p. m. 8 stools, watery, yellow and coming with a gush. Felt an emptiness with this diarrhoea, but no pain whatever. At 1 took 15 dr., and repeated dose at 2. At 3:25 another similar stool. At 5 took 25 dr. At 5:25 stool as before, and again at 6; pulse then 100, temp. normal. Felt a little weak, chilly up and down back; glad to go to bed about 7:30; eyeballs sore on movement; dull throbbing ache at front and top of head. At 9 another stool. Feverish heat now, beginning in face, extended all over body; pulse 100. Fell asleep at 9:30, and spent one of the most wretched n. he ever experienced; smart fever, increased pain in head, general malaise (no thirst), very restless, talking, moaning, with some delirium. Stool at 1 a. m. Took belladonna, with some relief to fever and restlessness; but sleep disturbed by many distressing dreams. Ate a light breakfast. Headache, eyeballs very sore, tongue slightly furred. At 10 a. m. took some china. Stool at 2 p. m., yellow, better digested, but coming with gush. Eyelids stiff and very heavy after an hour’s nap, very profound (as sleep has generally been since beginning proving); also considerable distress in stomach and lower half of oesophagus, – this was removed by pulsatilla. 2nd. – Slept quietly and very profoundly; eyes in m. sore on movement. Five painless but watery stools. On 4th, continuing to have 5 to 10 similar stools daily, took gambogia 3, two doses of which cured it. (Trans. of N. Y. state Hom. Medorrhinum Soc., N. S. ii, 122). 9a. DRASCHE experimented on a number of patients with infusion of 3j. Some took it cold, some hot; some took it all at once, some by installments. In all there occurred increase of salivary secretion and perspiration. The salivation always occurred, and was so copious that in some case as much as 200 – 300 cm. of saliva were collected in 2 – 3 hours; it was of neutral reaction, sp. gr. 1002, containing much albumen. The increased secretion began to appear in 10 – 15 m. after taking medicine. The perspiration generally appeared first on face and chest, in numerous large drops. It lasted 2 – 3 hours; not longer, however, than on salivation. Both sometimes occurred whether the medicine was swallowed cold or hot, but in the latter case the perspiration was more copious. The patients had at the same time a feeling of increased warmth and face became red and turgid. The temp. at the commencement of the action rose from some tenths to 1″degree C., but afterwards fell rather below normal. In the beginning pulse was slightly quickened, but later it became slower. Sphygmographic tracings showed a very considerable contraction of the arteries during the action of the medicine. In some patients transient derangements of vision were observed, and only in a few slight contraction of the pupils. The urinary secretion was not increased but rather diminished. In some cases there was urging to urinate, and tickling sensation in urethra. No effect was produced on the bowels, but some patients had eructations, nausea, and inclination to vomit; these symptoms only occurred when the whole drachm was swallowed at once. There was no after – symptoms.
9b. When the drug was given in tincture, the salivation always ensued, but the perspiration was not always present. When 3ij of tinct., corresponding to Zj in infusion, were taken, salivation and perspiration was very copious. Visual derangements were very slight, or sometimes absent altogether. The tinct. seemed to be not so certain in its action as the infusion. (Zeitsch. day allg. oster. Apotheker – Verbascum, May, 1875.) 10a. Among the incidental effects which have been observed, mention should first be made of the vomiting which occurs from 1/2 hours to 1 hours after taking the drug, and which is always preceded by prolonged nausea. It is extremely annoying and exhausting to the patient, lasts for a long time, and may readily lead to dangerous collapse. In 41 experiments Riegel observed it 18 times, and 10 times nausea without vomiting. Lohrisch, in 30 cases, saw violent vomiting 12 times, and nausea with inclination to vomit 22 times. The nausea showed itself sometimes immediately, sometimes 1/2 hours and even later, after taking the medicine.
10b. After the nausea and vomiting, increased frequency of micturition is the most common symptom, occurring in about 40 percent of the cases. It appears so suddenly, and the desire so great, that the patients are absolutely unable to resist it. Now and then a burning pain the urethra and small of the back is also noticed, which is so intense as to draw loud cries of suffering from the patients.
10c. The disturbances of vision so frequently noticed are also worthy of mention. The patients state that they are unable to see distinctly because there seems to be a veil before their eyes. A few authors claim also to have observed dilatation (? contraction. – EDS.) of the pupils in these cases, but Riegel was not able to confirm this statement.
10d. In addition to these incidental effects, there also occur not infrequently hiccup, dizziness, headache, with a kind of stupefaction, and in some cases, a more or less intense chilliness appearing near the close of the sweating, and also gastric and abdominal pains. After the cessation of the sweating, these symptoms come to an end. In very weak persons collapse without vomiting is occasionally observed. (LEWIN, op. cit.).
Experiments on animals
1a. In animals which perspire, it has been possible to ascertain that all the secretions connected with the alimentary canal – the bile and pancreatic juice, as well as the saliva – are increased. In dogs it produces a copious and sanguinolent diarrhoea. The urinary secretion, besides, is augmented in dogs; and there exists also an abundant flow of nasal and conjunctival mucus. Introduced into the stomach or into the crural veins, J. dilates the pupil (this, however, fails to occur when the sympathetic is divided in the neck). In toxic doses, J. retards considerably the beats of the heart, and sometimes ends by arresting them completely in diastole like muscarine. Applied directly, however, to the heart of the frog, J. arrests the heart in systole like digitaline. Atropine destroys its effects on the heart, and also arrests its salivation and sweating. The temperature of the animals experimented upon is generally elevated.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.