5 b. May 8th, at 9:30 p. m., took 3 dr.; on 9th, at 6 and 10 a. m., 5 dr, and at 9:30 p. m., 6 dr. 10th. 0 At 6 a. m., 8 dr. One hour after, confusion of sight; light-head and dizzy, much worse from sudden movement of head and heat in face. At 9:30, violent cramp-like pains in epigastrium, causing a momentary cry, lasting but a moment and then subsiding, leaving a constricted sensation for 1 hour. This was followed by sensation of heat and burning in stomach. At 2:30 p. m., 8 dr. At 3, pressive pain in right temple, with dizziness and blurred vision, such as may follow use of intoxicating liquor, but without exhilarating effects. The dizziness and blurred vision were attended by nausea, and continued for 3 hours. There were also pains in left elbow, wrist, and knee, and in both ankles; and pulse remained accelerated. The sensitiveness of brain continued for several hour, and it appeared as if every step and sudden movement of head would excite. pain; but this did not occur. 12h. – At 6 a. m., 6 dr. and at 2:30 p. m., 8 dr. At 3:30, dizziness and blurred vision returned, and gradually increased so that all objects appeared very indistinct till 6:30, when it as gradually abated. Face was flushed and hot to touch; eyes suffused. (Amer. Hom. Rev., ii, 80).
6. a. I have at various times, when in health, taken a few pellets saturated with the tinct. dry on the tongue. No symptoms save some fulness of anterior part of head, felt within a few morning of each dose, and soon disappearing.
6 b. April 3rd, 1864, just before going to bed, took 4 dr. of tinct. on tongue. In 15 morning, stitch traversing right eyelids vertically; afterwards, sense of contraction in scalp at centre of forehead. Sound sleep till 8 a. m. On rising, again 4 dr., and same at 11 a. m. Insufficient stool at 10 a. m. Walking and other exertion easily induced perspiration. At noon, slight heartburn and pain at cardia, while reading. At 8 p. m. 4 dr. and at 11 p. m., 5 dr. In afternoon and evening some irritability of right testis, and, afterwards, dragging pain in same, extending to both groins and hypogastrium, followed by escape of flatus, and relief of pain. At 11:30 p. m., eructations of wind and bland fluid; intense but transient itching of small points on face and at edge of hair at several spots; itching about elbows and forearms; aching in left rectus femurs, and drawing in right calf; sneezing, followed by tingling and sense of fullness in nose. At midnight, 6 dr.; sound sleep till 7 a. m., difficult weary waking. 5th. -After rising, 7 dr. General vivacity; at breakfast, dull ache on right side of head; gastric oppression had to loosen waist-bands, after which colicky sensation to left of navel as if stool would shortly pass. After breakfast, transient vertiginous sensation, followed by confused vision, especially of distant objects; when turning eyes, sense of sight is tardy in following movement, things appearing for several seconds to be blurred, and eye remaining unfixed in its new direction (no sensation of gauze or film). This gradually wore off by night. Sound sleep during most of night 6th. – At 8 a. m. took of a new specimen 5 dr. General vigorous filing. After breakfast, marked renewal of confusion of sight, with heavy- looking eyes. Found this symptom much less when holding a finger vertically beyond nose, also when either eye was closed. When reclining some languor throbbing in right side of head (previously, at breakfast, transient and slight cutting pressure on left side). Some heat and dryness of hands at 10 a. m.; at 11, pulse, sitting, 76. P. m., languor and drowsiness on attempting to study in reclining position; slept an hour, and on being aroused felt at first unwilling to move, eye transiently bloodshot. After moving about awhile has languor. Pulse, lying, 54-60, sitting up, 64-68; hands, especially palms, hot and dry. E., pulse 72, when sitting – always full and strong, as usual. Wakeful till 1 a. m., with desire to study. Irritation of small spots on mucous surface of prepuce with surrounding congestion. Sound sleep latter part of night; weary waking. 7th. – At 10 a. m., 5 dr., and at 2 p. m., 7 dr. At 4, swallowed a dessert- spoonful of red wine. Directly after, for first time to-day, return of confusion of sight, lasting but an hour, but so extreme that it seemed as if someone must suspect inebriation. Previously, depression of spirits with dull uncertain pains in head; coincident with intoxicated feeling gastralgia and colic. During evening, colicky pains below navel, extending to testes, and caused by flatus, being relieved by its expulsion. 8th. -At 8 a. m., 8 dr. Sight more or less confused all day. At 11 cardialgia, while riding. Dulness of head. at 3 p. m., whilst reading excitable news, transient chilliness in upper half of body, especially back and nape of neck. AT 11:30, 9 dr. At 12:30, rising of tasteless, semi-solid matters in esophagus with flatus and a sense as of something lodged therein, slightly painful, while sitting at study. Sound sleep. 9th. – Found sore pimple on left side of neck. Took 10 dr. Exciting news caused urging to stool; stool was deep yellow and papescent (as it was yesterday). Dull pain in right head; transient cramping pain in inner thigh when walking; eye symptoms as before. At 5:30 p. m., 15 dr. In an hour rheumatic pains in right knee and left neck-latter while lying down, former when walking; soon passed off. Confusion of sight much increased during evening. At 9:30, sneezing and dull headache; continued cardialgia and eructations while sitting; pulse 72. Pimple is sore, with areola, altogether size of pea, quite red and inflamed -an eruption not previously experienced. 10th. At 8:30 a. m., 21 dr. Till 4 p. m. disturbance of sight was great; mind listless and incapable of reflection, with dull (not severe) headache all day, and digging in right ear all p. m. at 9:30, soft bilious stool, preceded by threatenings of diarrhoea – latter renewed at noon by exciting news and afterwards in walking. When walking so, feeling in knees joint as of partial luxation. Several times during day saliva was found yellowish as if from blood; and all latter part of day bad, sour, spoiled taste and breath, with frequent need to rinse mouth or spit, light whitish coat on tongue. At 5, contractive sensation in right neck; afterwards while writing headache, first on vertex, then in left occiput, subsequently on both sides, in upper cervical region, and again on top-all in a few morning. Finally, settled, dull, dragging headache, mainly in occipital, mastoid, and upper cervical region, extending to shoulders, relieved while sitting by reclining head and shoulders on a high pillow. Early sleep after dinner. When roused some headache still; mind composed and clear (11:30 p. m.). After writing a while, pulse 64- 68; palms dry and hot, as also lips. 11th. – Three more pimples, like minute boils. No more med. was taken; and prover’s normal condition being disturbed by a professionally broken night, his symptoms to-day are not recorded. Pimples were not disappearing by 15th. (J. C. MORGAN, M. D., in Hale’s New Remedies, 2nd ed.)
7. To see what the effects of the drug would be when push I gave to a patient, a sailor, convalescent from periostitis, 3 doses of 20 min. of tinct. each, – 2 hours intervening between 1st and 2nd doses, and 1 hour between 2nd and 3rd. About 1/2 after 2nd dose, usual complaint was made of difficulty of keeping eyes open from heaviness of lids. He saw things double, one image appearing beside the other. During this time pulse did not appear to be much affected, remaining at 77; but after 3rd dose it became quickened, rising gradually to 96. About 2 hours after taking 3rd dose he got out of bed to go to lavatory, being perfectly conscious. He reached the room but found himself then powerless, and quietly sank first on his knees and then at full length. He was quite unable to raise his lids; his lower jaw dropped, and he could not articulate. He was put into bed, and some warm stimulating drink given him, when he soon became better. He told me when I saw him, with the most open-eyed simplicity, that the medicine had done him a great deal of good, for he could make water very much better since he had had it (I should observe that he had previously suffered from the effects of a troublesome stricture); that he knew everything that was going on around him when he sank to the ground, but was unable to move, and that his feelings were like those which he had experienced after commencement of intoxication. (Lancet, 1874)
8. a. I gave it to 6 persons on 17th occasions, in doses sufficient to produce decided toxic effects. The tinct. used was made with 1 part of root to 4 of rectified spirit. To excite the symptoms characteristic of this drug I found it generally necessary to give drachm doses hourly, for 3 hour. – a quantity which may be given with perfect safety. Some individuals, however, are much more prone to be affected than others. Thus, a woman suffered from diplopia, headache, and hazy sight after a second dose of 10 min.; and in another case 2 doses of 20 min., at 2 hour interval, produced well-marked symptoms. On the other hand, I have given drachm doses hourly, for 6 hours, with very slight effect; and in one instance I gave 20 min. to a delicate young woman every 3 hours for several day, finally causing only slight heaviness of eyelids.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.