15. a. A bull terrier, weighing 30 lbs., bitten on outside of right hind thigh. He drew up leg, and whined for a few morning. The wound bled a drop or two, and the muscles about it twitched considerably at intervals drop or two, and the muscles about it twitched considerably at intervals for an hours, when this symptom was obscured by the swelling. His pulse, which was naturally about 145 and irregular, was at he 5th morning 140 and regular; respiration 35. At the 15th morning he lay down much weakened, pulse 160 and feeble; respiration 40. At the 20th morning the bowels moved loosely, with a grey discharge, and their seemed to be some tenesmus in the rectum. At the 25th morning he could stand when urged, but lay down again at once, and was much weaker. In 45 morning, pulse 160; respiration 45, and laborious. In 55 morning, loss of power in hind legs. In 80 morning respiration quick and laboured, and so irregular as to make it impossible longer to count the heart pulses. Observation now interrupted; and on resuming, 3 hours afterwards, he was found dead. He had no foam about mouth, and probably died quietly.
15 b. P. M.- Whole muscular and areolar tissue of leg and thighs, half way up and down limb, was dark with infiltrated blood. About wound, Swelling was due to a mass of blood partially coagulated. Extravasated blood extended through limb, and on in side it passed half way up sartorius and adductors, and along sheath of vessels to within 2 in. of femoral ring. Nearly an inch of th sheath was clear of it, but 1/2 in. below the ring tissues were shaded with blood, and same appearance was seen around ring itself. From this point extravasation extended under peritoneum, into pelvis, and on inner face of ileum. The colour of tissues thus stained was a brilliant scarlet. Abdominal viscera were healthy, except that mucous membrane of lower bowels was somewhat congested. Lungs were sound. Hart was relaxed, right side full, left nearly empty. Blood on right side was a little darker than that on left; on both sides, and everywhere else, it was perfectly fluid and free from clots. Placed in a vial, it remained fluid until decomposition ensued. Two hours at least after death, some of the blood-globules found in heart were slightly indented; those taken from small vessels of ear were perfectly normal. (Ibid.)
16. a.- A young dog; bitten, but place not discovered. He immediately cried out as though in great pain. Within 5 morning he was trembling in every muscle. At 20th morning he was so much better he was subjected to a second bite, on neck, in front, above left shoulder. He at once lay down, then rose and passed water and solid faeces, and at 5th morning after second bite fell on his side and vomited freely. The vomiting was instantly followed by general convulsions, in which limbs were extended and head thrown back. Meanwhile, heart was very feeble, breathing laborious, and pupils contracted. The character of the respirations at this time was singular, – eight or ten rapid respirations took place, and then none occurred until 20 seconds had elapsed. The heart-beat, previously 180, fell, at 15th morning after second bite, to 80, an became remarkably feeble. At 17th morning respiration stopped, and heart pulse, though so weak as to be counted with difficulty, rose to 156, falling again, at 24th morning, to 58, when it became indistinct through weakness. Pupils dilated. Death.
16 b. P. M.- section was delayed 24 hours. Post-mortem rigor came on first about fore-legs and neck, and was complete 4 hours after death. It was so strong as to snap a small cord with which I had drawn the legs of the dog apart. The wound was the seat of an extravasation, which had passed over the shoulder and on to the neck. The vessels near it were filled with dark and diffluent blood. The muscles near the wound were softened and readily torn. The heart contained an abundance of blood, chiefly fluid, with a number of small clots of very loose structure in the right side, and somewhat less into he left cavities. In the pericardium there was about 1 1/2 oz. of bloody seem. The abdominal organs were healthy, and the peritoneum contained only a little straw-coloured serum. The bladder was partially contracted, and held an ounce or two of slightly albuminous urine. (Ibid.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.