26 c. Frequent trials were made with the drug, each time increasing the dose, until the last, when 56 gr. were taken. The same general symptoms were present each time, except that the last dose did not have any effect.
26 d. A large number of my friends (about 30) tried the drug, most of them under my eye, and the same result was invariably obtained, viz. clairvoyance; heaviness of the forearm and feet; hard, dry cough; desire for and dread of water; some had tetanic spasm at moment water was taken, others had some frothing at the mouth. A painless yellow diarrhoea was present in every case; eyes dull and swollen; heavy frontal headache; loss of appetite. All persons were relieved of their symptoms as fast as the effect of drug had passed off, which was usually in from 10 to 24 h. One or two were a little constipated for a few d. Coffee almost instantly relieved headache following. Some had great fear, at times, of things either real or unreal, and at other times the mind wandered into delightful realms.
26 e. Two ladies whom I persuaded to try the drug took 10 gr. each, and experienced same general symptoms: but they had in addition very profuse menstruation which lasted 5 d. At another time, several months after, they tried it again with the same result. They had always menstruated regularly; one had never any uterine or vaginal troubles (G.M. PEASE, M. D., N. Engl. Medorrhinum Gaz., i, 204.).
1. Mr. C – took gr. ss of ext. about 4 p.m., at 4:30 same; at 4:45 gr.j; at 5 and 5:15 gr. ij. Took tea as usual at 6:30. At 7:30 noticed that he gave wrong change to a customer, and felt somewhat nervous and dizzy. A few m. afterwards went out on an errand, felt irresistible inclination to run; and at same time sense of contraction of entre genito-urinary system, and great desire to micturate, with much strangury on doing so; also excessive dryness of fauces, coming on suddenly and with much thirst. On returning to his place of business found it impossible to keep still, on account of irresistible desire to be constantly on his feet. At this point I first saw him, and found him walking at quick pace, almost on his toes, round a room about 8 ft. square. Within a few m. spasms supervened, during which at times flexors and extensors, at time abductors and adductors of whole body were thrown into violent alternate action. While sitting in a chair, one m. his feet would beat a tattoo on the floor, and the next his knees beat violently together. Spasms increased in severity and frequency for 1/2 h., and then gradually diminished, after emesis had been induced. He could, by strong exercise of will, retrain spasms, but on fresh access they were much more violent. They were unaccompanied by pain, but after a time he experienced sense of easiness, as after spasms of tetanus. He describes his mind as being “dull” and somewhat confused, but without any loss of consciousness. Only once was there any mental disturbance, when he thought vomitus was head of hippopotamus, and again, a bunch of earthworms. He noticed that if anything ludicrous were said or done, or any idea suggested which required more than most common exercise of mind, spasms were considerably intensified. Senses of vision and feeling somewhat diminished; tinnitus aurium; conjunctiva much congested. Pulse at 8.30 about 140, somewhat irregular in character and frequency; at 10 it was 90. After an emetic symptoms passed off in 24 – 30 h. (F.H. BROWNE, Bost. Medorrhinum and Surg. Journ., lxii, 291.)
2. Surgeon, second officer, and Custom-house officer on a ship (at Calcutta) took some extract to experience stimulant and exhilarating action only; dose was too strong, and I learnt from the surgeon that they had about 3 gr. each. They were in state of collapse. Stimulants soon roused the doctor. Second officer required external and internal stimulants and cold affusions, and the poor Custom-house officer, being weaker, had nearly succumbed; it took 2 h. before he was out of danger, with the aid of turpentine enema, cold affusions, ammonia and constant moving about. Next d. they all had headache and lassitude. Effects seemed to be same as those of opium; contracted pupil, pale, clammy countenance, and stupor unless roused. (Lond. and Ed. Medorrhinum Journ., xiv, 270.)
3. A young Hindu was admitted about 4 p.m., April 5th. He was in the habit of smoking bhang or ganjah, and had smoked it that m. His symptoms were, total insensibility; sensation completely in abeyance; ano reflex action could be excited by tickling soles or by pinching skin; nor was latter felt; eyes were open and fixed vacantly, pupils natural; jaw fixed and immovable; mouth closed. The arms could be flexed or extended easily, but in whatever position they were placed they remained; thus when stretched out in front of him, or when placed vertically above head, they remained in the position until moved again. Lower extremities, too, could be placed in any position, and remained so. In spite of douches and other local measures, he continued in same condition till 8th, when he lay as it were asleep, breathing calmly; eyeballs turned upwards; muscles of arms and legs quite relaxed; very slight reflex action when soles are pinched or tickled; loudest calling or roughest shaking does not rouse. Seven h. later I found him being led about by two friends, moaning incessantly, and with difficulty prevented from putting hands into mouth, apparently to bite them; continually opening and shutting mouth. Two d. subsequently there were signs of returning consciousness; he could be roused by calling to him in a very loud voice, when he turned towards speaker, but then relapsed into same condition, and walked to and fro, moaning continually. Next d. consciousness was regained, but he had lost all recollection of what had occurred from m. of day of admission. (Medorrhinum Times and Gaz., xviii, 135 (1859).)