3. CHOUPPE divided the two pneumogastrics in a dog, which was then allowed to rest until the vomiting produced by the operation had entirely subsided. He then made a subcutaneous or intravenous injection of apomorphine, tartar emetic, and ipecacuanha. With the two former, vomiting occurred as quickly and as freely as when the nerves were intact; with the third vomiting never occurred. (Gaz. Medorrhinum de Paris, Aug. 1, 1874.)
4. SIEBERT and MOORZ have shown that A. does not affect the blood – pressure, and that the pulse rises when emesis comes on, reaches its maximum during vomiting, and declines in the interval. It causes at first increased rapidity of breathing, afterwards diminishes the force and depth of the movements, and finally arrests them. This result occurs even when the vagi are divided. It has no appreciable influence on the temperature. As respects its influence on the nervous system, it is at first strongly excitant. Afterwards it causes muscular tremblings, followed by paralysis and convulsions. The muscular irritability is impaired but not destroyed, and the functions of motor and sensory nerves remain intact. (BARTHOLOW, op. cit.).
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.