1b. In September, 1859, the same man was again stung in the same region, producing the following symptoms:-Sudden prostration, with coldness; pulseless at wrist for 20 m.; rapid feeble beats of the heart; dyspnoea; it seemed impossible to breathe; “had to fan him to keep him alive,” said his father. This was succeeded by hot flashes, nausea, vomiting, and copious watery diarrhea, twitching of the muscles, rash, red blotches, with great sensitiveness of the skin to contact. This sensitiveness of the skin extended all over the body. Bursting, expansive pain in the heat, attended by vertigo and confusion of the mind; was unable to think clearly or express himself. Drank about half a pint of diluted alcohol, as an antidote, without experiencing any intoxicating effect. The critical symptoms disappeared after three or four hours, leaving him much prostrated, from which he was a long time in recovering. Has not been able to endure hard labour since; is affected, upon exerting himself, with headache, expansive pain all over the head, vertigo, and palpitation. (N.Y. St. Hom. Soc. Trans., iii, 104.) 2. Miss-was stung by a bee on r. neck; a few m. thereafter the experienced sensation of heat and stinging extending over whole body. Face became much swollen, and eyelids puffed up; lids averted. Sickness at stomach and pain over whole body, latter so severe as to occasion crying. Body covered with large wheals, slightly raised, and quite white; interspaces being deep scarlet. Pain in head and eye-balls; mouth very dry; throat constricted, as if something were lodged there; deglutition painful. About a week later, when symptoms had subsided, patient had an attack of nettle-rash. (Ibid., N. S., i, 152.) 3. Mr. -has frequently been stung by bees. In 5 or 10 m. he feels, as first symptom, a heartburn; he has also experienced frequent and long-lasting erections as an effect. (Ibid.) 4. A girl, et. 25, was suddenly attacked, without known cause, by the following symptoms:-Face bloated, cyanotic; respiration slow, difficult; commencing pulmonary edema; sensorium confused; pulse small, quick; extremities cool. All r. arm was swollen, and cubital, axillary, and cervical glands on that side enlarged. On offering water, which patient urgently demanded, sudden convulsions, with expression of utmost anxiety in face, as in hydrophobia. Convulsions also occurred when physician accidentally took hold of forefinger. In middle of this finger a bee-sting was observed sticking, surrounded by a small red areola. On removing this, convulsions ceased, and therewith dread of water. Patient rapidly recovered, and next day was quite well, save for weakness. She said symptoms commenced almost immediately after being stung. (Allg. hom. Zeit., xcvii, No. 5.) 5. After a sting on the eyebrow, sudden sinking of the vital power, violent vomiting, copious diarrhea, cold limbs, pale place, violent, cutting pains in abdomen, pulse weak, scarcely to be felt; no redness or pain at the place where the sting was made, only after the other symptoms had gone some redness of the stung point was seen. (BISHOP, Am. Arz., p. 230.) 6. A boy, et. 7, when playing, was stung by a bee on the finger. Some chilliness all over, felt very unwell, had to go home and lie down. On undressing saw eruption of nettle-rash all over, that itched much. (RAUE, Ibid.) 7. After a bee-sting on finger there came a red place with some swelling and a painful stripe along the arms, in course of lymphatics, and sickness even to vomiting. (HERING, Ibid.) 8. A girl, et. 10, who had often previously been stung by bees without anything following but burning pain and redness, was stung in the neck under the maxillary bone. In 1/2 h. she began to feel burning and pricking in hands, especially palms, which got very red. Cold water relieved the burning. The same sensation soon spread on whole face, which got very hot and red; she had also nervous restlessness, so that she could not remain in one place, and the tears came into her eyes. The upper lip was so much swollen as though it were turned inside out. Countenance so much changed that she could hardly be recognized. Soon the burning spread to the feet and was now all over body. When undressed she was found to be covered with red places the size of a hand, as though they had been scalded. This was 40 to 50 m. after the sting. She had a severe rigor, though it was a warm day. The face remained swollen. She complained of great anxiety in head, and the whole nervous system seemed much affected. After sleep gradually became after, and next m., 18 h. after sting, was well. (LANGSTROTH, Ibid., p. 231.) 9. A boy, et. 10, was stung by a bee on r. commissure of mouth. At once feeling of general numbness, and after a few m. the most violent itching like needle pricks, had to rub the whole body with cloths in order to allay, it after rubbing he was observed to be covered from head to foot with small, white spots, as after gnat-bites. This lasted 1/2 h., then swelling was considerable. In a few h. the right eye was completely closed and the left nearly so. Cheeks and nose were on same level, chest like a great board, the lower part of the cheeks hung down towards chest. The swelling lasted several day (COXE, Phil. Medorrhinum Museum, N. S. i, 150, 184, quoted in Ibid., p. 232.) 10. A man, et. 26, was stung by a bee on the cheek, but felt no inconvenience. A quarter of an hours afterwards he was stung on the lower surface of the tip of the nose. He suddenly felt an indescribable sensation through the whole body, with a pricking feeling, and white and red spots on the palms, arms, and legs. At the same time tears flowed involuntarily from the eyes, the nose and face swelled, he became hoarse, lost his taste, had pressure in scrob. cordis and difficulty of breathing. On the way home, about half a mile, he left a great desire to sleep, with increasing dyspnoea, and on reaching home his face, neck, chest, and limbs were considerably swollen, and the other symptoms had increased. He drank a little water in which salt was dissolved, and dabbed his face with it. Soon afterwards he had a rigor with cold limbs and nausea. He got 10 gr. Dover’s powder and several doses of the expressed juice of plantain, also a lotion of plantain and lettuce. Plantain leaves were laid on his face, and in about an hours the symptoms began to abate. The swelling of the face lasted several days and the prickly feeling returned after exertion for several weeks. (JAMES MEASE, Am. Journ. of Medorrhinum Sc., Nov., 1836, quoted in Ibid., p. 236.) 11. A woman was stung by a bee between the mammae. In about 10 m. the toes of both feet felt too large, swollen, and stiff. Soon the same sensation came in the head; it felt so large she looked in the glass to see if it were actually swollen. Then the whole body felt too large. She felt so queer that she lay down at full length on the ground, she knew not why, because she did not feel so faint, only so queer, that she thought she should die. She was bled, but without relief, then she got ammonia and laudanum and felt better, but the whole abdomen was covered with very elevated long stripes. (HERING, Ibid., p. 239.) 12. A man was stung by a bee in the l. testicle. The part swelled to such an extent that there was scarcely room for it in the scrotum, with tensive feeling and the most violent itching. Soon afterwards the whole left side of the body swelled, first in the joints, where lumps appeared which looked somewhat inflamed and itched violently. The cervical glands also on the stung side were swollen. Soon after the sting he felt a faint sick sensation under short ribs and all over abdomen. This lasted 3 h. At same time dull heavy pain in sinciput and sides of head, relieved by pressing with hands. (RAUE, Ibid., p. 242.) 13. A woman was stung by a bee on the temple. Immediately she got pain in teeth, trembling and working of lips and tongue, dyspnoea, retching, several fainting fits, whereon perspiration broke out all over and an urticarious rash spread all over the body; then rigor, copious evacuation of blackish-brown, green, and white faces, stitch in the side. Next day well (MULLER, Medorrhinum Correspondenzbl. d. Wurtemb. artz. Verbascum, ix, No.3, quoted in Ibid., p.243.) 14. A robust man, et. 35, was stung by a bee on the top of his head. He felt no pain on the place. In 20 to 30 m. his tongue swelled, [ “There is scarcely a remedy that has such marked symptoms of glossitis as Apis. In one case of poisoning the inflammatory swelling was not the result of a sting on the organ, or of the introduction of the poison into the stomach, so that the inflammation might be accounted for by local action; but it occurred after a sting in the temple, showing that the virus had a specific effect on the tongue.” (BAHR, Soc. of Theridion, tr. by Hempel, i, 313.)] then his face, especially about eyes; the swelling then extended all over the body. The swollen tongue prevented him speaking, and soon his breathing from the same cause became so difficult that the doctor found him in danger of suffocation about 45 m. after the sting. The breathing was gasping and difficult like that of a child with croup. The whole body was covered with wheals, but without change of colours, indeed the wheals were whiter than the rest of the skin. The upper eyelids hung down over the eyes on to the cheeks. He could not put out his tongue, could not swallow a drop nor speak a word. He was bled to 20 oz. and was soon relieved. (Philadelphia Public Ledger, 22nd June, 1852, quoted in Ibid, p. 243.) 15a. A middle-aged man was stung behind l. ear. Shortly after a sudden dizziness came over him, and his head became so full that he thought he was going to have a fit. These symptoms were followed by rigors; when he felt so ill and weak that he at once undressed and went to bed, not without considerable assistance. He made a fruitless attempt to urinate, and thereupon followed the state of skin to be described.
Hughes was a great writer and a scholar. He actively cooperated with Dr. T.F. Allen to compile his 'Encyclopedia' and rendered immeasurable aid to Dr. Dudgeon in translating Hahnemann's 'Materia Medica Pura' into English. In 1889 he was appointed an Editor of the 'British Homoeopathic Journal' and continued in that capacity until his demise. In 1876, Dr. Hughes was appointed as the Permanent Secretary of the Organization of the International Congress of Homoeopathy Physicians in Philadelphia. He also presided over the International Congress in London.